Reduced tissue and serum resistin expression as a clinical marker for esophageal squamous cell carcinoma
Esophageal cancer is one of the most common malignancies and leading cause of cancer-associated mortality worldwide. However, the molecular mechanisms underlying esophageal cancer progression and the development of clinical tools for effective diagnosis remain unclear. Resistin, which was originally...
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| Veröffentlicht in: | Oncology letters 2021-11, Vol.22 (5), p.1, Article 774 |
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| creator | Hung, Amos C Wang, Yen-Yun Lee, Kun-Tsung Chiang, Hung-Hsing Chen, Yuk-Kwan Du, Je-Kang Chen, Chun-Ming Chen, Michael Yuanchien Chen, Kwei-Jing Hu, Stephen Chu-Sung Shyng-Yuan, Shiou F |
| description | Esophageal cancer is one of the most common malignancies and leading cause of cancer-associated mortality worldwide. However, the molecular mechanisms underlying esophageal cancer progression and the development of clinical tools for effective diagnosis remain unclear. Resistin, which was originally identified as an adipose tissue-secretory factor, has been associated with obesity-related diseases, including certain types of cancer. Thus, the present study aimed to investigate the expression levels of resistin in tissue and serum specimens from patients with esophageal squamous cell carcinoma (ESCC) to determine the potential biological effects of resistin on ESCC cells. The results demonstrated that both tissue and serum resistin levels were significantly lower in patients with ESCC compared with healthy controls. In addition, resistin expression was positively associated with the body mass index of patients with ESCC. In vitro studies revealed that resistin inhibited the migratory ability of ESCC cells, while having no effect on ESCC cell proliferation. Taken together, these results suggest that resistin may have the potential to be developed into a clinical marker for ESCC. However, further studies are required to investigate resistin receptor expression and determine the potential involvement of resistin-associated biological pathways, which may provide insight for future development of targeted therapies for resistin-mediated ESCC. |
| doi_str_mv | 10.3892/ol.2021.13035 |
| format | Article |
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However, the molecular mechanisms underlying esophageal cancer progression and the development of clinical tools for effective diagnosis remain unclear. Resistin, which was originally identified as an adipose tissue-secretory factor, has been associated with obesity-related diseases, including certain types of cancer. Thus, the present study aimed to investigate the expression levels of resistin in tissue and serum specimens from patients with esophageal squamous cell carcinoma (ESCC) to determine the potential biological effects of resistin on ESCC cells. The results demonstrated that both tissue and serum resistin levels were significantly lower in patients with ESCC compared with healthy controls. In addition, resistin expression was positively associated with the body mass index of patients with ESCC. In vitro studies revealed that resistin inhibited the migratory ability of ESCC cells, while having no effect on ESCC cell proliferation. Taken together, these results suggest that resistin may have the potential to be developed into a clinical marker for ESCC. However, further studies are required to investigate resistin receptor expression and determine the potential involvement of resistin-associated biological pathways, which may provide insight for future development of targeted therapies for resistin-mediated ESCC.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2021.13035</identifier><identifier>PMID: 34589153</identifier><language>eng</language><publisher>Athens: Spandidos Publications</publisher><subject>Adipose tissues ; Alcohol ; Amino acids ; Cancer ; Cell adhesion & migration ; Cell culture ; Cell growth ; Chemotherapy ; Development and progression ; Esophageal cancer ; Health aspects ; Lymphatic system ; Metastasis ; Mortality ; Oncology ; Oncology, Experimental ; Radiation therapy ; Smoking ; Software ; Squamous cell carcinoma ; Statistical analysis ; Taiwan ; Thoracic surgery</subject><ispartof>Oncology letters, 2021-11, Vol.22 (5), p.1, Article 774</ispartof><rights>COPYRIGHT 2021 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2021</rights><rights>Copyright: © Hung et al. 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-1ad768b85c0f50b6712d607d13b96e3edf6a00eeeeb8920494fbb7808456d8043</citedby><cites>FETCH-LOGICAL-c490t-1ad768b85c0f50b6712d607d13b96e3edf6a00eeeeb8920494fbb7808456d8043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442229/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442229/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Hung, Amos C</creatorcontrib><creatorcontrib>Wang, Yen-Yun</creatorcontrib><creatorcontrib>Lee, Kun-Tsung</creatorcontrib><creatorcontrib>Chiang, Hung-Hsing</creatorcontrib><creatorcontrib>Chen, Yuk-Kwan</creatorcontrib><creatorcontrib>Du, Je-Kang</creatorcontrib><creatorcontrib>Chen, Chun-Ming</creatorcontrib><creatorcontrib>Chen, Michael Yuanchien</creatorcontrib><creatorcontrib>Chen, Kwei-Jing</creatorcontrib><creatorcontrib>Hu, Stephen Chu-Sung</creatorcontrib><creatorcontrib>Shyng-Yuan, Shiou F</creatorcontrib><title>Reduced tissue and serum resistin expression as a clinical marker for esophageal squamous cell carcinoma</title><title>Oncology letters</title><description>Esophageal cancer is one of the most common malignancies and leading cause of cancer-associated mortality worldwide. However, the molecular mechanisms underlying esophageal cancer progression and the development of clinical tools for effective diagnosis remain unclear. Resistin, which was originally identified as an adipose tissue-secretory factor, has been associated with obesity-related diseases, including certain types of cancer. Thus, the present study aimed to investigate the expression levels of resistin in tissue and serum specimens from patients with esophageal squamous cell carcinoma (ESCC) to determine the potential biological effects of resistin on ESCC cells. The results demonstrated that both tissue and serum resistin levels were significantly lower in patients with ESCC compared with healthy controls. In addition, resistin expression was positively associated with the body mass index of patients with ESCC. In vitro studies revealed that resistin inhibited the migratory ability of ESCC cells, while having no effect on ESCC cell proliferation. Taken together, these results suggest that resistin may have the potential to be developed into a clinical marker for ESCC. However, further studies are required to investigate resistin receptor expression and determine the potential involvement of resistin-associated biological pathways, which may provide insight for future development of targeted therapies for resistin-mediated ESCC.</description><subject>Adipose tissues</subject><subject>Alcohol</subject><subject>Amino acids</subject><subject>Cancer</subject><subject>Cell adhesion & migration</subject><subject>Cell culture</subject><subject>Cell growth</subject><subject>Chemotherapy</subject><subject>Development and progression</subject><subject>Esophageal cancer</subject><subject>Health aspects</subject><subject>Lymphatic system</subject><subject>Metastasis</subject><subject>Mortality</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Radiation therapy</subject><subject>Smoking</subject><subject>Software</subject><subject>Squamous cell carcinoma</subject><subject>Statistical analysis</subject><subject>Taiwan</subject><subject>Thoracic surgery</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptUl1rFTEQXUSxpfbR94Dg297ma7PZF6EUPwoFQfQ5ZJPZu6nZ5DazK_rvTW2pXnDykGFy5szkcJrmNaM7oQd-keOOU852TFDRPWtOWT_wllHNnz_lvTxpzhFvaY1OMa3Vy-ZEyE4PrBOnzfwF_ObAkzUgbkBs8gShbAspgAHXkAj8PNQcQ07EIrHExZCCs5EstnyHQqZcCGA-zHYPtYp3m13yhsRBjMTZ4kLKi33VvJhsRDh_vM-abx_ef7361N58_nh9dXnTOjnQtWXW90qPunN06uioesa9or1nYhwUCPCTspRCjbEKQOUgp3HsNdWyU15TKc6adw-8h21cwDtIa7HRHEqo6_4y2QZz_JLCbPb5h9FScs6HSvDmkaDkuw1wNbd5K6nubHhXBylJe_UXtbcRTEhTrmRuCejMpdKca8G7vqJ2_0HV42EJLieYQq0fNbz9p2Gueq4z5ritVX08BrYPQFcyYoHp6YeMmntvmBzNvTfMH2-I33PnqlU</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Hung, Amos C</creator><creator>Wang, Yen-Yun</creator><creator>Lee, Kun-Tsung</creator><creator>Chiang, Hung-Hsing</creator><creator>Chen, Yuk-Kwan</creator><creator>Du, Je-Kang</creator><creator>Chen, Chun-Ming</creator><creator>Chen, Michael Yuanchien</creator><creator>Chen, Kwei-Jing</creator><creator>Hu, Stephen Chu-Sung</creator><creator>Shyng-Yuan, Shiou F</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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However, the molecular mechanisms underlying esophageal cancer progression and the development of clinical tools for effective diagnosis remain unclear. Resistin, which was originally identified as an adipose tissue-secretory factor, has been associated with obesity-related diseases, including certain types of cancer. Thus, the present study aimed to investigate the expression levels of resistin in tissue and serum specimens from patients with esophageal squamous cell carcinoma (ESCC) to determine the potential biological effects of resistin on ESCC cells. The results demonstrated that both tissue and serum resistin levels were significantly lower in patients with ESCC compared with healthy controls. In addition, resistin expression was positively associated with the body mass index of patients with ESCC. In vitro studies revealed that resistin inhibited the migratory ability of ESCC cells, while having no effect on ESCC cell proliferation. Taken together, these results suggest that resistin may have the potential to be developed into a clinical marker for ESCC. However, further studies are required to investigate resistin receptor expression and determine the potential involvement of resistin-associated biological pathways, which may provide insight for future development of targeted therapies for resistin-mediated ESCC.</abstract><cop>Athens</cop><pub>Spandidos Publications</pub><pmid>34589153</pmid><doi>10.3892/ol.2021.13035</doi><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adipose tissues Alcohol Amino acids Cancer Cell adhesion & migration Cell culture Cell growth Chemotherapy Development and progression Esophageal cancer Health aspects Lymphatic system Metastasis Mortality Oncology Oncology, Experimental Radiation therapy Smoking Software Squamous cell carcinoma Statistical analysis Taiwan Thoracic surgery |
| title | Reduced tissue and serum resistin expression as a clinical marker for esophageal squamous cell carcinoma |
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