Histone chaperone FACT complex inhibitor CBL0137 interferes with DNA damage repair and enhances sensitivity of medulloblastoma to chemotherapy and radiation

Medulloblastoma (MB) is a malignant pediatric brain tumor with a poor prognosis. Post-surgical radiation and cisplatin-based chemotherapy have been a mainstay of treatment, which often leads to substantial neurocognitive impairments and morbidity, highlighting the need for a novel therapeutic target...

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Veröffentlicht in:	Cancer letters 2021-11, Vol.520, p.201-212
Hauptverfasser:	Song, Heyu, Xi, Shaoyan, Chen, Yingling, Pramanik, Suravi, Zeng, Jiping, Roychoudhury, Shrabasti, Harris, Hannah, Akbar, Anum, Elhag, Salma S., Coulter, Donald W., Ray, Sutapa, Bhakat, Kishor K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adolescent Adult Animals Antibodies APE1 Brain cancer Brain tumors Cancer therapies Carbazoles - administration & dosage Carbazoles - adverse effects CBL0137 Chemotherapy Child Child, Preschool Chromatin remodeling Cisplatin Cisplatin - administration & dosage Cisplatin - adverse effects Cognition Cytotoxicity Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects DNA Damage - radiation effects DNA repair DNA Repair - drug effects DNA Repair - radiation effects DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics Drug Resistance, Neoplasm - drug effects FACT Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - radiation effects Heterografts High Mobility Group Proteins - antagonists & inhibitors High Mobility Group Proteins - genetics Histone Chaperones - genetics Histones Humans Male Medulloblastoma Medulloblastoma - drug therapy Medulloblastoma - genetics Medulloblastoma - pathology Medulloblastoma - radiotherapy Mice Morbidity Patients Pediatrics Radiation therapy Transcription Transcriptional Elongation Factors - antagonists & inhibitors Transcriptional Elongation Factors - genetics Xenografts Young Adult
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