Somatic reversion impacts myelodysplastic syndromes and acute myeloid leukemia evolution in the short telomere disorders

BACKGROUNDGermline mutations in telomerase and other telomere maintenance genes manifest in the premature aging short telomere syndromes. Myelodysplastic syndromes and acute myeloid leukemia (MDS/AML) account for 75% of associated malignancies, but how these cancers overcome the inherited telomere d...

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Veröffentlicht in:	The Journal of clinical investigation 2021-09, Vol.131 (18), p.1-9
Hauptverfasser:	Schratz, Kristen E, Gaysinskaya, Valeriya, Cosner, Zoe L, DeBoy, Emily A, Xiang, Zhimin, Kasch-Semenza, Laura, Florea, Liliana, Shah, Pali D, Armanios, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Adolescent Adult Age Aged Aged, 80 and over Aging Binding sites Biomedical research Bone marrow Case-Control Studies Child Clinical Medicine Development and progression Female Gene mutations Genes Genetic aspects Germ-Line Mutation Health aspects High-Throughput Nucleotide Sequencing Humans Leukemia Leukemia, Myeloid, Acute - genetics Male Melanoma Middle Aged Mutation Myelodysplastic syndrome Myelodysplastic syndromes Myelodysplastic Syndromes - genetics Myeloid leukemia Patients Promoter Regions, Genetic Pulmonary fibrosis Reversion RNA - genetics Shelterin Complex Skin cancer Telomerase Telomerase - genetics Telomere - genetics Telomere Shortening - genetics Telomere-Binding Proteins - genetics Telomeres Young Adult
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