Collateral effects of deletion of nlpD on rpoS and rpoS-dependent genes
To the Editor: A seminal article, titled "Active bacterial modification of the host environment through RNA polymerase II inhibition," was published in the JCI in February 2021 (1). [...]since nlpD is complicated, as marginally referred to in Supplemental Figure 5 in the article by Ambite...
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| Veröffentlicht in: | The Journal of clinical investigation 2021-09, Vol.131 (18), p.1-1 |
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| container_title | The Journal of clinical investigation |
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| creator | Tsunoi, Manami Iyoda, Sunao Iwase, Tadayuki |
| description | To the Editor: A seminal article, titled "Active bacterial modification of the host environment through RNA polymerase II inhibition," was published in the JCI in February 2021 (1). [...]since nlpD is complicated, as marginally referred to in Supplemental Figure 5 in the article by Ambite et al., we here include detailed information about nlpD. nlpD is positioned upstream of rpoS; rpoS encodes the RNA polymerase sigma factor a38 (RpoS) that regulates many genes, as shown in a recent study that identified differential expression of1044 genes between the wild-type and rpoS mutant (2). Identification of transcriptional start sites and the role of ppGpp in the expression of rpoS, the structural gene for the sigma S subunit of RNA polymerase in Escherichia coli. |
| doi_str_mv | 10.1172/JCI152693 |
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[...]since nlpD is complicated, as marginally referred to in Supplemental Figure 5 in the article by Ambite et al., we here include detailed information about nlpD. nlpD is positioned upstream of rpoS; rpoS encodes the RNA polymerase sigma factor a38 (RpoS) that regulates many genes, as shown in a recent study that identified differential expression of1044 genes between the wild-type and rpoS mutant (2). Identification of transcriptional start sites and the role of ppGpp in the expression of rpoS, the structural gene for the sigma S subunit of RNA polymerase in Escherichia coli.</description><identifier>ISSN: 1558-8238</identifier><identifier>ISSN: 0021-9738</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/JCI152693</identifier><identifier>PMID: 34523610</identifier><language>eng</language><publisher>Ann Arbor: American Society for Clinical Investigation</publisher><subject>Bacteriology ; Biomedical research ; DNA-directed RNA polymerase ; E coli ; Genes ; Letter to the Editor ; RNA polymerase ; Sigma factor ; Transcription</subject><ispartof>The Journal of clinical investigation, 2021-09, Vol.131 (18), p.1-1</ispartof><rights>COPYRIGHT 2021 American Society for Clinical Investigation</rights><rights>Copyright American Society for Clinical Investigation Sep 2021</rights><rights>2021 American Society for Clinical Investigation 2021 American Society for Clinical Investigation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c650t-2ccaff3a6f92c19dd175ef06bbf246ecbd636493019f7ff5a5c6bc59c299c8fd3</citedby><cites>FETCH-LOGICAL-c650t-2ccaff3a6f92c19dd175ef06bbf246ecbd636493019f7ff5a5c6bc59c299c8fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439590/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439590/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids></links><search><creatorcontrib>Tsunoi, Manami</creatorcontrib><creatorcontrib>Iyoda, Sunao</creatorcontrib><creatorcontrib>Iwase, Tadayuki</creatorcontrib><title>Collateral effects of deletion of nlpD on rpoS and rpoS-dependent genes</title><title>The Journal of clinical investigation</title><description>To the Editor: A seminal article, titled "Active bacterial modification of the host environment through RNA polymerase II inhibition," was published in the JCI in February 2021 (1). [...]since nlpD is complicated, as marginally referred to in Supplemental Figure 5 in the article by Ambite et al., we here include detailed information about nlpD. nlpD is positioned upstream of rpoS; rpoS encodes the RNA polymerase sigma factor a38 (RpoS) that regulates many genes, as shown in a recent study that identified differential expression of1044 genes between the wild-type and rpoS mutant (2). 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| subjects | Bacteriology Biomedical research DNA-directed RNA polymerase E coli Genes Letter to the Editor RNA polymerase Sigma factor Transcription |
| title | Collateral effects of deletion of nlpD on rpoS and rpoS-dependent genes |
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