IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media
Inflammatory mediators play an important role in the pathogenesis of otitis media by initiating and maintaining an inflammatory response to infection. The presence of inflammatory mediators may be one of the reasons, in some patients, for acute otitis media transforming into chronic otitis media. Th...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2021-11, Vol.22 (5), Article 1226 |
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| container_title | Experimental and therapeutic medicine |
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| creator | Serban, Roxana Filip, Cristiana Radulescu, Luminita Badescu, Minerva Badescu, Magda Diaconescu, Bogdan Cobzeanu, Mihail Cobzeanu, Bogdan |
| description | Inflammatory mediators play an important role in the pathogenesis of otitis media by initiating and maintaining an inflammatory response to infection. The presence of inflammatory mediators may be one of the reasons, in some patients, for acute otitis media transforming into chronic otitis media. The present study included 60 patients admitted to the Clinical Rehabilitation Hospital, Iasi, Romania, for surgery. The control group comprised 30 healthy individuals. Serum levels of interleukin 1α (IL-1α), interleukin 6 (IL-6) and interleukin 8 (IL-8) were measured prior to surgery and were compared among patients with chronic suppurative otitis media (CSOM), cholesteatoma and cholesteatoma recidivism and the control group. High serum levels of interleukins were recorded in all the groups compared to the healthy control group. IL-6 and IL-8 had the highest value in patients with CSOM and IL-1α had the highest value in patients with cholesteatoma recidivism. Thus, we can consider that inflammatory mediators play a central role in the pathogenesis of CSOM and cholesteatoma by maintaining a systemic and local inflammatory response. |
| doi_str_mv | 10.3892/etm.2021.10660 |
| format | Article |
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The presence of inflammatory mediators may be one of the reasons, in some patients, for acute otitis media transforming into chronic otitis media. The present study included 60 patients admitted to the Clinical Rehabilitation Hospital, Iasi, Romania, for surgery. The control group comprised 30 healthy individuals. Serum levels of interleukin 1α (IL-1α), interleukin 6 (IL-6) and interleukin 8 (IL-8) were measured prior to surgery and were compared among patients with chronic suppurative otitis media (CSOM), cholesteatoma and cholesteatoma recidivism and the control group. High serum levels of interleukins were recorded in all the groups compared to the healthy control group. IL-6 and IL-8 had the highest value in patients with CSOM and IL-1α had the highest value in patients with cholesteatoma recidivism. Thus, we can consider that inflammatory mediators play a central role in the pathogenesis of CSOM and cholesteatoma by maintaining a systemic and local inflammatory response.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2021.10660</identifier><identifier>PMID: 34539822</identifier><language>eng</language><publisher>Athens: Spandidos Publications UK Ltd</publisher><subject>Anticoagulants ; Binding sites ; Chronic illnesses ; Cytokines ; Ear diseases ; Males ; Recidivism ; Rural areas ; Tumor necrosis factor-TNF ; Urban areas</subject><ispartof>Experimental and therapeutic medicine, 2021-11, Vol.22 (5), Article 1226</ispartof><rights>Copyright Spandidos Publications UK Ltd. 2021</rights><rights>Copyright: © Serban et al. 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c280t-df0d3896013968a29b09b3b3bbaf1f4fedfa0f38783710ba937b53db977111b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438691/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438691/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Serban, Roxana</creatorcontrib><creatorcontrib>Filip, Cristiana</creatorcontrib><creatorcontrib>Radulescu, Luminita</creatorcontrib><creatorcontrib>Badescu, Minerva</creatorcontrib><creatorcontrib>Badescu, Magda</creatorcontrib><creatorcontrib>Diaconescu, Bogdan</creatorcontrib><creatorcontrib>Cobzeanu, Mihail</creatorcontrib><creatorcontrib>Cobzeanu, Bogdan</creatorcontrib><title>IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media</title><title>Experimental and therapeutic medicine</title><description>Inflammatory mediators play an important role in the pathogenesis of otitis media by initiating and maintaining an inflammatory response to infection. The presence of inflammatory mediators may be one of the reasons, in some patients, for acute otitis media transforming into chronic otitis media. The present study included 60 patients admitted to the Clinical Rehabilitation Hospital, Iasi, Romania, for surgery. The control group comprised 30 healthy individuals. Serum levels of interleukin 1α (IL-1α), interleukin 6 (IL-6) and interleukin 8 (IL-8) were measured prior to surgery and were compared among patients with chronic suppurative otitis media (CSOM), cholesteatoma and cholesteatoma recidivism and the control group. High serum levels of interleukins were recorded in all the groups compared to the healthy control group. IL-6 and IL-8 had the highest value in patients with CSOM and IL-1α had the highest value in patients with cholesteatoma recidivism. Thus, we can consider that inflammatory mediators play a central role in the pathogenesis of CSOM and cholesteatoma by maintaining a systemic and local inflammatory response.</description><subject>Anticoagulants</subject><subject>Binding sites</subject><subject>Chronic illnesses</subject><subject>Cytokines</subject><subject>Ear diseases</subject><subject>Males</subject><subject>Recidivism</subject><subject>Rural areas</subject><subject>Tumor necrosis factor-TNF</subject><subject>Urban areas</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpVUUtKBDEQDaI4Ms7WdcCt3aaS_iQbQQY_AwNudOMmpLvTTobpj0l6xJ1X8ChexEN4EjMfBKsW9aCK96rqIXQGJGZc0Evtm5gSCjGQLCMH6ARyQSMgkB7uMREcRmji3JKESDPgPD1GI5akTHBKT9DzbP7z8QnfXxd4izKs2moHOXbaDg1eq9WgHTYt7pU3uvUOvxm_wOXCdq0psRv6frChtda488YbhxtdGXWKjmq1cnqyr2P0dHvzOL2P5g93s-n1PCopJz6qalKFazICTGRcUVEQUbCQhaqhTmpd1YrUjOec5UAKJVhepKwqRJ4DQJGxMbra8fZDEYTLsKFVK9lb0yj7Ljtl5P9OaxbypVtLnjCeCQgE53sC272GU71cdoNtw86SppyKJHyUh6l4N1Xazjmr6z8FIHJjhwx2yI0dcmsH-wUdz39s</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Serban, Roxana</creator><creator>Filip, Cristiana</creator><creator>Radulescu, Luminita</creator><creator>Badescu, Minerva</creator><creator>Badescu, Magda</creator><creator>Diaconescu, Bogdan</creator><creator>Cobzeanu, Mihail</creator><creator>Cobzeanu, Bogdan</creator><general>Spandidos Publications UK Ltd</general><general>D.A. 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The presence of inflammatory mediators may be one of the reasons, in some patients, for acute otitis media transforming into chronic otitis media. The present study included 60 patients admitted to the Clinical Rehabilitation Hospital, Iasi, Romania, for surgery. The control group comprised 30 healthy individuals. Serum levels of interleukin 1α (IL-1α), interleukin 6 (IL-6) and interleukin 8 (IL-8) were measured prior to surgery and were compared among patients with chronic suppurative otitis media (CSOM), cholesteatoma and cholesteatoma recidivism and the control group. High serum levels of interleukins were recorded in all the groups compared to the healthy control group. IL-6 and IL-8 had the highest value in patients with CSOM and IL-1α had the highest value in patients with cholesteatoma recidivism. Thus, we can consider that inflammatory mediators play a central role in the pathogenesis of CSOM and cholesteatoma by maintaining a systemic and local inflammatory response.</abstract><cop>Athens</cop><pub>Spandidos Publications UK Ltd</pub><pmid>34539822</pmid><doi>10.3892/etm.2021.10660</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Anticoagulants Binding sites Chronic illnesses Cytokines Ear diseases Males Recidivism Rural areas Tumor necrosis factor-TNF Urban areas |
| title | IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media |
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