Metformin attenuates angiotensin II‑induced cardiomyocyte hypertrophy by upregulating the MuRF1 and MAFbx pathway

Pathological cardiac hypertrophy induced by aging and neurohumoral activation, such as angiotensin II (Ang II) activation, is an independent risk factor for heart failure. The muscle really interesting new gene-finger protein-1 (MuRF1) and muscle atrophy F-box (MAFbx) pathway has been previously rep...

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Veröffentlicht in:	Experimental and therapeutic medicine 2021-11, Vol.22 (5), Article 1231
Hauptverfasser:	Du, Fawang, Cao, Yalin, Ran, Yan, Wu, Qiang, Chen, Baolin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidiabetics Binding proteins Biotechnology Cardiomyocytes Cardiomyopathy Development and progression Disease Dosage and administration Drug therapy Gene expression Glucose Health aspects Heart enlargement Ischemia Metformin Peptides Physiological aspects Proteins
Online-Zugang:	Volltext
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