Proteomic characterization of secretory granules in dopaminergic neurons indicates chromogranin/secretogranin-mediated protein processing impairment in Parkinson's disease

Parkinson's disease (PD) is an aging disorder related to vesicle transport dysfunctions and neurotransmitter secretion. Secretory granules (SGs) are large dense-core vesicles for the biosynthesis of neuropeptides and hormones. At present, the involvement of SGs impairment in PD remains unclear....

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2021-08, Vol.13 (16), p.20335-20358
Hauptverfasser:	Wen, Gehua, Pang, Hao, Wu, Xu, Jiang, Enzhu, Zhang, Xique, Zhan, Xiaoni
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - genetics Apolipoproteins E - metabolism Chromogranins - genetics Chromogranins - metabolism Dopaminergic Neurons - chemistry Dopaminergic Neurons - metabolism Humans Male Mice Mice, Inbred C57BL Neuropeptide Y - genetics Neuropeptide Y - metabolism Parkinson Disease - genetics Parkinson Disease - metabolism Proteins - genetics Proteins - metabolism Proteomics Research Paper Secretory Vesicles - chemistry Secretory Vesicles - genetics Secretory Vesicles - metabolism
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