ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 1 , 2 and is responsible for the coronavirus disease 2019 (COVID-19) pandemic 3 . Vaccines are an essential countermeasure and are urgently needed to control the pandemic 4 . Here we show that the adenovirus-vector...

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Veröffentlicht in:	Nature (London) 2020-10, Vol.586 (7830), p.578-582
Hauptverfasser:	van Doremalen, Neeltje, Lambe, Teresa, Spencer, Alexandra, Belij-Rammerstorfer, Sandra, Purushotham, Jyothi N., Port, Julia R., Avanzato, Victoria A., Bushmaker, Trenton, Flaxman, Amy, Ulaszewska, Marta, Feldmann, Friederike, Allen, Elizabeth R., Sharpe, Hannah, Schulz, Jonathan, Holbrook, Myndi, Okumura, Atsushi, Meade-White, Kimberly, Pérez-Pérez, Lizzette, Edwards, Nick J., Wright, Daniel, Bissett, Cameron, Gilbride, Ciaran, Williamson, Brandi N., Rosenke, Rebecca, Long, Dan, Ishwarbhai, Alka, Kailath, Reshma, Rose, Louisa, Morris, Susan, Powers, Claire, Lovaglio, Jamie, Hanley, Patrick W., Scott, Dana, Saturday, Greg, de Wit, Emmie, Gilbert, Sarah C., Munster, Vincent J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/31 13/51 14/63 631/326/590 631/326/596/4130 64/60 Adenoviridae - genetics Alveoli Analysis Animal models Animals Betacoronavirus - immunology Bronchoalveolar Lavage Fluid Bronchus Clinical trials Control Coronavirus Infections - genetics Coronavirus Infections - immunology Coronavirus Infections - prevention & control Coronavirus Infections - virology Coronaviruses COVID-19 COVID-19 Vaccines Cytokines Cytokines - immunology Diagnosis Disease Models, Animal Female Health aspects Helper cells Humanities and Social Sciences Immune response Immune response (cell-mediated) Immune response (humoral) Immune system Immunity, Cellular Immunity, Humoral Immunogenicity Immunoglobulin G Immunoglobulin G - immunology Lung - immunology Lung - pathology Lung - virology Macaca mulatta - immunology Macaca mulatta - virology Male Mice Middle East respiratory syndrome multidisciplinary Pandemics Pandemics - prevention & control Pneumonia Pneumonia, Viral - immunology Pneumonia, Viral - prevention & control Pneumonia, Viral - virology Respiratory diseases Respiratory tract Rhesus monkey Rodents SARS-CoV-2 Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Spike protein Testing Th1 Cells - immunology Vaccination Vaccines Viral diseases Viral Load Viral pneumonia Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology
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