Molecular basis for acetyl-CoA production by ATP-citrate lyase

ATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental cellular building block. Accordingly, aberrant ACLY activity is observed in many diseases. Here we report cryo-EM structures of human ACLY, alone or bound to substrates or products. ACLY forms a homotetramer...

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Veröffentlicht in:	Nature structural & molecular biology 2020-01, Vol.27 (1), p.33-41
Hauptverfasser:	Wei, Xuepeng, Schultz, Kollin, Bazilevsky, Gleb A., Vogt, Austin, Marmorstein, Ronen
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/173 631/535/1258/1259 Acetyl Coenzyme A - metabolism Ashes ATP ATP Citrate (pro-S)-Lyase - chemistry ATP Citrate (pro-S)-Lyase - metabolism ATP Citrate (pro-S)-Lyase - ultrastructure ATP citrate lyase Biochemistry Biological Microscopy Biomedical and Life Sciences Biophysics Coenzyme A Cryoelectron Microscopy Domains Enzymes Homology Humans Life Sciences Ligands Medicine Membrane Biology Metabolic disorders Metabolism Metabolites Models, Molecular Molecular biology Mutants Protein Binding Protein Conformation Protein Multimerization Protein Structure Proteins Substrate Specificity Substrates
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