PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis

: Protein arginine methyltransferase 4 (PRMT4) has been reported to play a role in several common cancers; however, the function and mechanism of PRMT4 in hepatocellular carcinoma (HCC) are not fully understood. This study aimed to investigate the role and mechanism of PRMT4 in the progression of HC...

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Veröffentlicht in:	International journal of medical sciences 2021-01, Vol.18 (15), p.3588-3598
Hauptverfasser:	Du, Peng, Luo, Kaifeng, Li, Guoyong, Zhu, Jisheng, Xiao, Qi, Li, Yong, Zhang, Xingjian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biomarkers, Tumor - metabolism Cancer therapies Carcinoma, Hepatocellular - genetics Down-Regulation - genetics Humans Liver cancer Liver Neoplasms - genetics Medical prognosis Membranes Prognosis Protein-Arginine N-Methyltransferases - genetics Proteins Proto-Oncogene Proteins c-akt - metabolism Reagents Research Paper Signal Transduction - genetics TOR Serine-Threonine Kinases - metabolism Transcription factors Tumorigenesis
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