Impaired immunomodulatory capacity in adipose tissue‐derived mesenchymal stem/stromal cells isolated from obese patients

Immune‐modulatory properties of adipose tissue‐derived mesenchymal stem/stromal cells (MSCs) might be susceptible to metabolic disturbances. We hypothesized that the immune‐modulatory function of MSCs might be blunted in obese human subjects. MSCs were collected from abdominal subcutaneous fat of ob...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2021-09, Vol.25 (18), p.9051-9059
Hauptverfasser:	Zhu, Xiang‐Yang, Klomjit, Nattawat, Conley, Sabena M., Ostlie, Megan M., Jordan, Kyra L., Lerman, Amir, Lerman, Lilach O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adolescent Adult Aged Aged, 80 and over Animals Biomarkers - analysis Body fat Bone marrow Cells, Cultured Cytokines Diabetes Female Flow cytometry Gene expression Genotype & phenotype Human subjects Humans Immunomodulation Immunomodulators Inflammation Kidneys macrophage Macrophages Macrophages - immunology Macrophages - pathology Male Mesenchymal stem cells Mesenchymal Stem Cells - immunology Mesenchymal Stem Cells - pathology Mesenchyme Metabolism Mice Middle Aged Obesity Obesity - immunology Original Phenotypes Renal artery renal artery stenosis Stenosis Stromal cells Surgery Tumor necrosis factor Veins & arteries Young Adult
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