Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis

The etiology of colorectal cancer (CRC) is complex. Approximately, 10% of individuals with CRC have predisposing germline mutations that lead to familial cancer syndromes, whereas most CRC patients have sporadic cancer resulting from a combination of environmental and genetic risk factors. It has be...

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Veröffentlicht in:	Cancers 2021-08, Vol.13 (17), p.4404
Hauptverfasser:	Johnson, Caroline H, Golla, Jaya Prakash, Dioletis, Evangelos, Singh, Surendra, Ishii, Momoko, Charkoftaki, Georgia, Thompson, David C, Vasiliou, Vasilis
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde Alcoholism Antioxidants Biological activity Cancer Carcinogenesis Cell adhesion & migration Colorectal carcinoma Cytokines Dehydrogenases Deoxyribonucleic acid DNA DNA damage Enzymes Epigenetics Ethanol Etiology Fatty acids Fatty liver Genotoxicity Heat shock proteins Hepatitis Immune system Immunosuppression Inflammation Kinases Liver Liver cancer Liver diseases Metabolism Metabolites Microbiomes Molecular modelling Morbidity Mutation Oxidation Permeability Reactive oxygen species Review Risk factors Steatosis Therapeutic applications Tumorigenesis Tumors
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