Light-Inducible Spatio-Temporal Control of TLR4 and NF-κB-Gluc Reporter in Human Pancreatic Cell Line

Augmented Toll-like receptor 4 (TLR4) expression was found in nearly 70% of patients with pancreatic adenocarcinoma, which is correlated with increased tumorigenesis and progression. In this study, we engineered a new light-oxygen-voltage-sensing (LOV) domain-based optogenetic cell line (opto-TLR4 P...

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Veröffentlicht in:	International journal of molecular sciences 2021-09, Vol.22 (17), p.9232
Hauptverfasser:	Stierschneider, Anna, Grünstäudl, Petra, Colleselli, Katrin, Atzler, Josef, Klein, Christian T., Hundsberger, Harald, Wiesner, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Cancer therapies Cell adhesion Cloning Electric potential Extracellular signal-regulated kinase Fusion protein Ground level Kinases Molecular modelling NF-κB protein Pancreas Pancreatic cancer Phosphorylation Proteins Signal transduction TLR4 protein Toll-like receptors Tumorigenesis Voltage
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