Effective Oncoleaking Treatment of Pancreatic Cancer by Claudin-Targeted Suicide Gene Therapy with Clostridium perfringens Enterotoxin (CPE)

Pancreatic cancer (PC) is one of the most lethal cancers worldwide, associated with poor prognosis and restricted therapeutic options. Clostridium perfringens enterotoxin (CPE), is a pore-forming (oncoleaking) toxin, which binds to claudin-3 and -4 (Cldn3/4) causing selective cytotoxicity. Cldn3/4 a...

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Veröffentlicht in:	Cancers 2021-08, Vol.13 (17), p.4393
Hauptverfasser:	Pahle, Jessica, Kobelt, Dennis, Aumann, Jutta, Behrens, Diana, Daberkow, Ole, Mokritzkij, Margarita, Piontek, Jörg, Stein, Ulrike, Walther, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Cancer therapies Chemotherapy Clostridium perfringens Cytotoxicity Gene therapy Medical prognosis Necrosis Ovaries Pancreatic cancer Pancreatic carcinoma Patients Pheochromocytoma cells Plasmids Proteins RNA polymerase Suicide Suicide genes Toxins Tumors Xenografts
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