Low-Intensity Extracorporeal Shock Wave Therapy Promotes Bladder Regeneration and Improves Overactive Bladder Induced by Ovarian Hormone Deficiency from Rat Animal Model to Human Clinical Trial
Postmenopausal women with ovary hormone deficiency (OHD) are subject to overactive bladder (OAB) symptoms. The present study attempted to elucidate whether low-intensity extracorporeal shock wave therapy (LiESWT) alters bladder angiogenesis, decreases inflammatory response, and ameliorates bladder h...
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| Veröffentlicht in: | International journal of molecular sciences 2021-09, Vol.22 (17), p.9296 |
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| creator | Lin, Kun-Ling Lu, Jian-He Chueh, Kuang-Shun Juan, Tai-Jui Wu, Bin-Nan Chuang, Shu-Mien Lee, Yung-Chin Shen, Mei-Chen Long, Cheng-Yu Juan, Yung-Shun |
| description | Postmenopausal women with ovary hormone deficiency (OHD) are subject to overactive bladder (OAB) symptoms. The present study attempted to elucidate whether low-intensity extracorporeal shock wave therapy (LiESWT) alters bladder angiogenesis, decreases inflammatory response, and ameliorates bladder hyperactivity to influence bladder function in OHD-induced OAB in human clinical trial and rat model. The ovariectomized (OVX) for 12 months Sprague–Dawley rat model mimicking the physiological condition of menopause was utilized to induce OAB and assess the potential therapeutic mechanism of LiESWT (0.12 mJ/mm2, 300 pulses, and 3 pulses/second). The randomized, single-blinded clinical trial was enrolled 58 participants to investigate the therapeutic efficacy of LiESWT (0.25 mJ/mm2, 3000 pulses, 3 pulses/second) on postmenopausal women with OAB. The results revealed that 8 weeks’ LiESWT inhibited interstitial fibrosis, promoted cell proliferation, enhanced angiogenesis protein expression, and elevated the protein phosphorylation of ErK1/2, P38, and Akt, leading to decreased urinary frequency, nocturia, urgency, urgency incontinence, and post-voided residual urine volume, but increased voided urine volume and the maximal flow rate of postmenopausal participants. In conclusion, LiESWT attenuated inflammatory responses, increased angiogenesis, and promoted proliferation and differentiation, thereby improved OAB symptoms, thereafter promoting social activity and the quality of life of postmenopausal participants. |
| doi_str_mv | 10.3390/ijms22179296 |
| format | Article |
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The present study attempted to elucidate whether low-intensity extracorporeal shock wave therapy (LiESWT) alters bladder angiogenesis, decreases inflammatory response, and ameliorates bladder hyperactivity to influence bladder function in OHD-induced OAB in human clinical trial and rat model. The ovariectomized (OVX) for 12 months Sprague–Dawley rat model mimicking the physiological condition of menopause was utilized to induce OAB and assess the potential therapeutic mechanism of LiESWT (0.12 mJ/mm2, 300 pulses, and 3 pulses/second). The randomized, single-blinded clinical trial was enrolled 58 participants to investigate the therapeutic efficacy of LiESWT (0.25 mJ/mm2, 3000 pulses, 3 pulses/second) on postmenopausal women with OAB. The results revealed that 8 weeks’ LiESWT inhibited interstitial fibrosis, promoted cell proliferation, enhanced angiogenesis protein expression, and elevated the protein phosphorylation of ErK1/2, P38, and Akt, leading to decreased urinary frequency, nocturia, urgency, urgency incontinence, and post-voided residual urine volume, but increased voided urine volume and the maximal flow rate of postmenopausal participants. In conclusion, LiESWT attenuated inflammatory responses, increased angiogenesis, and promoted proliferation and differentiation, thereby improved OAB symptoms, thereafter promoting social activity and the quality of life of postmenopausal participants.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22179296</identifier><identifier>PMID: 34502202</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>AKT protein ; Angiogenesis ; Animal models ; Atrophy ; Bladder ; Cell proliferation ; Clinical trials ; Diabetes ; Estrogens ; Females ; Fibrosis ; Flow velocity ; Hyperactivity ; Inflammation ; Inflammatory response ; Lithotripsy ; Menopause ; Mimicry ; Nocturia ; Older people ; Ovariectomy ; Ovaries ; Oxidative stress ; Pain ; Penis ; Phosphorylation ; Physiology ; Post-menopause ; Proteins ; Quality of life ; Smooth muscle ; Surgery ; Urinary incontinence ; Urinary tract diseases ; Urinary tract infections ; Urine ; Urogenital system ; Vagina ; Womens health</subject><ispartof>International journal of molecular sciences, 2021-09, Vol.22 (17), p.9296</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-d8c4b484b9a4dcbb7ce4adfd07ac1c7c635bcbac85a6fe370ca18ec7fb3740e03</citedby><cites>FETCH-LOGICAL-c389t-d8c4b484b9a4dcbb7ce4adfd07ac1c7c635bcbac85a6fe370ca18ec7fb3740e03</cites><orcidid>0000-0001-6593-5120 ; 0000-0002-0607-9093 ; 0000-0001-9108-7567</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431217/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431217/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Lin, Kun-Ling</creatorcontrib><creatorcontrib>Lu, Jian-He</creatorcontrib><creatorcontrib>Chueh, Kuang-Shun</creatorcontrib><creatorcontrib>Juan, Tai-Jui</creatorcontrib><creatorcontrib>Wu, Bin-Nan</creatorcontrib><creatorcontrib>Chuang, Shu-Mien</creatorcontrib><creatorcontrib>Lee, Yung-Chin</creatorcontrib><creatorcontrib>Shen, Mei-Chen</creatorcontrib><creatorcontrib>Long, Cheng-Yu</creatorcontrib><creatorcontrib>Juan, Yung-Shun</creatorcontrib><title>Low-Intensity Extracorporeal Shock Wave Therapy Promotes Bladder Regeneration and Improves Overactive Bladder Induced by Ovarian Hormone Deficiency from Rat Animal Model to Human Clinical Trial</title><title>International journal of molecular sciences</title><description>Postmenopausal women with ovary hormone deficiency (OHD) are subject to overactive bladder (OAB) symptoms. The present study attempted to elucidate whether low-intensity extracorporeal shock wave therapy (LiESWT) alters bladder angiogenesis, decreases inflammatory response, and ameliorates bladder hyperactivity to influence bladder function in OHD-induced OAB in human clinical trial and rat model. The ovariectomized (OVX) for 12 months Sprague–Dawley rat model mimicking the physiological condition of menopause was utilized to induce OAB and assess the potential therapeutic mechanism of LiESWT (0.12 mJ/mm2, 300 pulses, and 3 pulses/second). The randomized, single-blinded clinical trial was enrolled 58 participants to investigate the therapeutic efficacy of LiESWT (0.25 mJ/mm2, 3000 pulses, 3 pulses/second) on postmenopausal women with OAB. The results revealed that 8 weeks’ LiESWT inhibited interstitial fibrosis, promoted cell proliferation, enhanced angiogenesis protein expression, and elevated the protein phosphorylation of ErK1/2, P38, and Akt, leading to decreased urinary frequency, nocturia, urgency, urgency incontinence, and post-voided residual urine volume, but increased voided urine volume and the maximal flow rate of postmenopausal participants. In conclusion, LiESWT attenuated inflammatory responses, increased angiogenesis, and promoted proliferation and differentiation, thereby improved OAB symptoms, thereafter promoting social activity and the quality of life of postmenopausal participants.</description><subject>AKT protein</subject><subject>Angiogenesis</subject><subject>Animal models</subject><subject>Atrophy</subject><subject>Bladder</subject><subject>Cell proliferation</subject><subject>Clinical trials</subject><subject>Diabetes</subject><subject>Estrogens</subject><subject>Females</subject><subject>Fibrosis</subject><subject>Flow velocity</subject><subject>Hyperactivity</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Lithotripsy</subject><subject>Menopause</subject><subject>Mimicry</subject><subject>Nocturia</subject><subject>Older people</subject><subject>Ovariectomy</subject><subject>Ovaries</subject><subject>Oxidative stress</subject><subject>Pain</subject><subject>Penis</subject><subject>Phosphorylation</subject><subject>Physiology</subject><subject>Post-menopause</subject><subject>Proteins</subject><subject>Quality of life</subject><subject>Smooth muscle</subject><subject>Surgery</subject><subject>Urinary incontinence</subject><subject>Urinary tract diseases</subject><subject>Urinary tract infections</subject><subject>Urine</subject><subject>Urogenital system</subject><subject>Vagina</subject><subject>Womens health</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdksFu1DAQhiMEoqVw4wEsceFAwLGTOLkglaXtrrRVUVnEMXLGk66XxA62szSP1zfDpQW1nGzN_83v3_YkyeuMvue8ph_0bvCMZaJmdfkkOcxyxlJKS_H0wf4geeH9jlLGWVE_Tw54XlDGKDtMbtb2V7oyAY3XYSYn18FJsG60DmVPvm4t_CDf5R7JZotOjjP54uxgA3ryqZdKoSOXeIUmakFbQ6RRZDWMzu4jcbGPZQg6dv-FV0ZNgIq0c1Sl09KQpXWDNUg-Y6dBo4GZdPEMcikDOTZ6iDHOrcKeBEuW0xA7Fr02GmJ9Ew36l8mzTvYeX92vR8m305PNYpmuL85Wi-N1CryqQ6oqyNu8ytta5graVgDmUnWKCgkZCCh50UIroSpk2SEXFGRWIYiu5SKnSPlR8vHOd5zaARWgiU_VN6OLEd3cWKmbx4rR2-bK7psq51n8n2jw9t7A2Z8T-tAM2gP2vTRoJ9-wQmQ1qwQtIvrmP3RnJ2fi9f5QjFdZeWv47o4CZ7132P0Lk9Hmdjaah7PBfwPJkbFX</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Lin, Kun-Ling</creator><creator>Lu, Jian-He</creator><creator>Chueh, Kuang-Shun</creator><creator>Juan, Tai-Jui</creator><creator>Wu, Bin-Nan</creator><creator>Chuang, Shu-Mien</creator><creator>Lee, Yung-Chin</creator><creator>Shen, Mei-Chen</creator><creator>Long, Cheng-Yu</creator><creator>Juan, Yung-Shun</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6593-5120</orcidid><orcidid>https://orcid.org/0000-0002-0607-9093</orcidid><orcidid>https://orcid.org/0000-0001-9108-7567</orcidid></search><sort><creationdate>20210901</creationdate><title>Low-Intensity Extracorporeal Shock Wave Therapy Promotes Bladder Regeneration and Improves Overactive Bladder Induced by Ovarian Hormone Deficiency from Rat Animal Model to Human Clinical Trial</title><author>Lin, Kun-Ling ; 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The present study attempted to elucidate whether low-intensity extracorporeal shock wave therapy (LiESWT) alters bladder angiogenesis, decreases inflammatory response, and ameliorates bladder hyperactivity to influence bladder function in OHD-induced OAB in human clinical trial and rat model. The ovariectomized (OVX) for 12 months Sprague–Dawley rat model mimicking the physiological condition of menopause was utilized to induce OAB and assess the potential therapeutic mechanism of LiESWT (0.12 mJ/mm2, 300 pulses, and 3 pulses/second). The randomized, single-blinded clinical trial was enrolled 58 participants to investigate the therapeutic efficacy of LiESWT (0.25 mJ/mm2, 3000 pulses, 3 pulses/second) on postmenopausal women with OAB. The results revealed that 8 weeks’ LiESWT inhibited interstitial fibrosis, promoted cell proliferation, enhanced angiogenesis protein expression, and elevated the protein phosphorylation of ErK1/2, P38, and Akt, leading to decreased urinary frequency, nocturia, urgency, urgency incontinence, and post-voided residual urine volume, but increased voided urine volume and the maximal flow rate of postmenopausal participants. In conclusion, LiESWT attenuated inflammatory responses, increased angiogenesis, and promoted proliferation and differentiation, thereby improved OAB symptoms, thereafter promoting social activity and the quality of life of postmenopausal participants.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34502202</pmid><doi>10.3390/ijms22179296</doi><orcidid>https://orcid.org/0000-0001-6593-5120</orcidid><orcidid>https://orcid.org/0000-0002-0607-9093</orcidid><orcidid>https://orcid.org/0000-0001-9108-7567</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | AKT protein Angiogenesis Animal models Atrophy Bladder Cell proliferation Clinical trials Diabetes Estrogens Females Fibrosis Flow velocity Hyperactivity Inflammation Inflammatory response Lithotripsy Menopause Mimicry Nocturia Older people Ovariectomy Ovaries Oxidative stress Pain Penis Phosphorylation Physiology Post-menopause Proteins Quality of life Smooth muscle Surgery Urinary incontinence Urinary tract diseases Urinary tract infections Urine Urogenital system Vagina Womens health |
| title | Low-Intensity Extracorporeal Shock Wave Therapy Promotes Bladder Regeneration and Improves Overactive Bladder Induced by Ovarian Hormone Deficiency from Rat Animal Model to Human Clinical Trial |
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