The Extracellular Matrix in Pancreatic Cancer: Description of a Complex Network and Promising Therapeutic Options

The stroma is a relevant player in driving and supporting the progression of pancreatic ductal adenocarcinoma (PDAC), and a large body of evidence highlights its role in hindering the efficacy of current therapies. In fact, the dense extracellular matrix (ECM) characterizing this tumor acts as a nat...

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Veröffentlicht in:	Cancers 2021-09, Vol.13 (17), p.4442
Hauptverfasser:	Ferrara, Benedetta, Pignatelli, Cataldo, Cossutta, Mélissande, Citro, Antonio, Courty, José, Piemonti, Lorenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Angiogenesis Antigens Blood vessels Cancer therapies Chemokines Chemotherapy Clinical trials Collagen Cytokines Drug delivery Drug resistance Extracellular matrix Fibroblasts Growth factors Medical prognosis Mesenchyme Metastasis Nanoparticles Pancreatic cancer Patients Perfusion Review Smooth muscle Stem cells Stroma Therapeutic targets
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