Fc Galactosylation Promotes Hexamerization of Human IgG1, Leading to Enhanced Classical Complement Activation

Human IgG contains one evolutionarily conserved N-linked glycan in its Fc region at position 297. This glycan is crucial for Fc-mediated functions, including its induction of the classical complement cascade. This is induced after target recognition through the IgG–Fab regions, allowing neighboring...

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Veröffentlicht in:	The Journal of immunology (1950) 2021-09, Vol.207 (6), p.1545-1554
Hauptverfasser:	van Osch, Thijs L. J., Nouta, Jan, Derksen, Ninotska I. L., van Mierlo, Gerard, van der Schoot, C. Ellen, Wuhrer, Manfred, Rispens, Theo, Vidarsson, Gestur
Format:	Artikel
Sprache:	eng
Schlagworte:	Immune Regulation
Online-Zugang:	Volltext
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