Genome‐wide association analysis of COVID‐19 mortality risk in SARS‐CoV‐2 genomes identifies mutation in the SARS‐CoV‐2 spike protein that colocalizes with P.1 of the Brazilian strain

SARS‐CoV‐2 mortality has been extensively studied in relation to host susceptibility. How sequence variations in the SARS‐CoV‐2 genome affect pathogenicity is poorly understood. Starting in October 2020, using the methodology of genome‐wide association studies (GWAS), we looked at the association be...

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Veröffentlicht in:	Genetic epidemiology 2021-10, Vol.45 (7), p.685-693
Hauptverfasser:	Hahn, Georg, Wu, Chloe M., Lee, Sanghun, Lutz, Sharon M., Khurana, Surender, Baden, Lindsey R., Haneuse, Sebastien, Qiao, Dandi, Hecker, Julian, DeMeo, Dawn L., Tanzi, Rudolph E., Choudhary, Manish C., Etemad, Behzad, Mohammadi, Abbas, Esmaeilzadeh, Elmira, Cho, Michael H., Li, Jonathan Z., Randolph, Adrienne G., Laird, Nan M., Weiss, Scott T., Silverman, Edwin K., Ribbeck, Katharina, Lange, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Association analysis Brazil COVID-19 Genome-Wide Association Study Genomes GISAID database Humans Infectivity logistic regression Mortality Mutation Nucleotide sequence Pathogenicity Phylogeny SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - genetics Spike protein Strains (organisms) Whole genome sequencing
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