Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes

Ammonia is a cytotoxic molecule generated during normal cellular functions. Dysregulated ammonia metabolism, which is evident in many chronic diseases such as liver cirrhosis, heart failure, and chronic obstructive pulmonary disease, initiates a hyperammonemic stress response in tissues including sk...

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Veröffentlicht in:	The Journal of biological chemistry 2021-09, Vol.297 (3), p.101023-101023, Article 101023
Hauptverfasser:	Welch, Nicole, Singh, Shashi Shekhar, Kumar, Avinash, Dhruba, Saugato Rahman, Mishra, Saurabh, Sekar, Jinendiran, Bellar, Annette, Attaway, Amy H., Chelluboyina, Aruna, Willard, Belinda B., Li, Ling, Huo, Zhiguang, Karnik, Sadashiva S., Esser, Karyn, Longworth, Michelle S., Shah, Yatrik M., Davuluri, Gangarao, Pal, Ranadip, Dasarathy, Srinivasan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bioinformatics Flow Cytometry Genomics glycosylation Humans Hyperammonemia - genetics Hyperammonemia - metabolism hypoxia-inducible factor Immunoblotting - methods Mice Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - metabolism Proteomics Real-Time Polymerase Chain Reaction Reproducibility of Results senescence skeletal muscle metabolism Transcriptome
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