Selected Clostridia Strains from The Human Microbiota and their Metabolite, Butyrate, Improve Experimental Autoimmune Encephalomyelitis

Summary Gut microbiome studies in multiple sclerosis (MS) patients are unravelling some consistent but modest patterns of gut dysbiosis. Among these, a significant decrease of Clostridia cluster IV and XIVa has been reported. In the present study, we investigated the therapeutic effect of a previous...

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Veröffentlicht in:	Neurotherapeutics 2021-04, Vol.18 (2), p.920-937
Hauptverfasser:	Calvo-Barreiro, Laura, Eixarch, Herena, Cornejo, Thais, Costa, Carme, Castillo, Mireia, Mestre, Leyre, Guaza, Carmen, Martínez-Cuesta, María del Carmen, Tanoue, Takeshi, Honda, Kenya, González-López, Juan José, Montalban, Xavier, Espejo, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmunity Biomedical and Life Sciences Biomedicine Butyrates - administration & dosage Central nervous system Clostridia Clostridiaceae - immunology Demyelination Dysbacteriosis Dysbiosis - immunology Dysbiosis - pathology Dysbiosis - therapy Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - therapy Experimental allergic encephalomyelitis Fatty Acids, Volatile - administration & dosage Female Gastrointestinal Microbiome - physiology Humans Immunomodulation Immunoregulation Interferon Intestinal microflora Lymphocytes T Macrophages Mice Mice, Inbred C57BL Microbiomes Microbiota Microglia Multiple sclerosis Neurobiology Neurology Neurosciences Neurosurgery Original Original Article Patients Strains (organisms) T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Transcriptomes
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