Hepatoprotective Plants from Bangladesh: A Biophytochemical Review and Future Prospect
Liver diseases are quite prevalant in many densely populated countries, including Bangladesh. The liver and its hepatocytes are targeted by virus and microbes, as well as by chemical environmental toxicants, causing wide-spread disruption of metabolic fuctions of the human body, leading to death fro...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2021, Vol.2021, p.1633231-39 |
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| description | Liver diseases are quite prevalant in many densely populated countries, including Bangladesh. The liver and its hepatocytes are targeted by virus and microbes, as well as by chemical environmental toxicants, causing wide-spread disruption of metabolic fuctions of the human body, leading to death from end-stage liver diseases. The aim of this review is to systematically explore and record the potential of Bangladeshi ethnopharmacological plants to treat liver diseases with focus on their sources, constituents, and therapeutic uses, including mechanisms of actions (MoA). A literature survey was carried out using Pubmed, Google Scholar, ScienceDirect, and Scopus databases with articles reported until July, 2020. A total of 88 Bangladeshi hepatoprotective plants (BHPs) belonging to 47 families were listed in this review, including Euphorbiaceae, Cucurbitaceae, and Compositae families contained 20% of plants, while herbs were the most cited (51%) and leaves were the most consumed parts (23%) as surveyed. The effect of BHPs against different hepatotoxins was observed via upregulation of antioxidant systems and inhibition of lipid peroxidation which subsequently reduced the elevated liver biomarkers. Different active constituents, including phenolics, curcuminoids, cucurbitanes, terpenoids, fatty acids, carotenoids, and polysaccharides, have been reported from these plants. The hepatoameliorative effect of these constituents was mainly involved in the reduction of hepatic oxidative stress and inflammation through activation of Nrf2/HO-1 and inhibition of NF-κB signaling pathways. In summary, BHPs represent a valuable resource for hepatoprotective lead therapeutics which may offer new alternatives to treat liver diseases. |
| doi_str_mv | 10.1155/2021/1633231 |
| format | Article |
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Raihan ; Sarker, Dipto Kumer ; Zahura, Fatima Tuz ; Uddin, Shaikh Jamal ; Muhammad, Ilias</creator><contributor>Mediani, Ahmed ; Ahmed Mediani</contributor><creatorcontrib>Rouf, Razina ; Ghosh, Puja ; Uzzaman, Md. Raihan ; Sarker, Dipto Kumer ; Zahura, Fatima Tuz ; Uddin, Shaikh Jamal ; Muhammad, Ilias ; Mediani, Ahmed ; Ahmed Mediani</creatorcontrib><description>Liver diseases are quite prevalant in many densely populated countries, including Bangladesh. The liver and its hepatocytes are targeted by virus and microbes, as well as by chemical environmental toxicants, causing wide-spread disruption of metabolic fuctions of the human body, leading to death from end-stage liver diseases. The aim of this review is to systematically explore and record the potential of Bangladeshi ethnopharmacological plants to treat liver diseases with focus on their sources, constituents, and therapeutic uses, including mechanisms of actions (MoA). A literature survey was carried out using Pubmed, Google Scholar, ScienceDirect, and Scopus databases with articles reported until July, 2020. A total of 88 Bangladeshi hepatoprotective plants (BHPs) belonging to 47 families were listed in this review, including Euphorbiaceae, Cucurbitaceae, and Compositae families contained 20% of plants, while herbs were the most cited (51%) and leaves were the most consumed parts (23%) as surveyed. The effect of BHPs against different hepatotoxins was observed via upregulation of antioxidant systems and inhibition of lipid peroxidation which subsequently reduced the elevated liver biomarkers. Different active constituents, including phenolics, curcuminoids, cucurbitanes, terpenoids, fatty acids, carotenoids, and polysaccharides, have been reported from these plants. The hepatoameliorative effect of these constituents was mainly involved in the reduction of hepatic oxidative stress and inflammation through activation of Nrf2/HO-1 and inhibition of NF-κB signaling pathways. In summary, BHPs represent a valuable resource for hepatoprotective lead therapeutics which may offer new alternatives to treat liver diseases.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2021/1633231</identifier><identifier>PMID: 34504532</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Antioxidants ; Ascites ; Carotenoids ; Fatty acids ; Fruits ; Hepatitis ; Hepatocytes ; Hepatotoxicity ; Herbal medicine ; Lipid peroxidation ; Liver diseases ; Medicine ; NF-κB protein ; Oxidative stress ; Polysaccharides ; Review ; Reviews ; Seeds ; Toxicants ; Trees</subject><ispartof>Evidence-based complementary and alternative medicine, 2021, Vol.2021, p.1633231-39</ispartof><rights>Copyright © 2021 Razina Rouf et al.</rights><rights>Copyright © 2021 Razina Rouf et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Razina Rouf et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-57af2a33e8785ee47ac6748bd67a9e0c46dff1f9f292b819eb5e16998f8639893</citedby><cites>FETCH-LOGICAL-c448t-57af2a33e8785ee47ac6748bd67a9e0c46dff1f9f292b819eb5e16998f8639893</cites><orcidid>0000-0003-3163-2118</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423546/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423546/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34504532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mediani, Ahmed</contributor><contributor>Ahmed Mediani</contributor><creatorcontrib>Rouf, Razina</creatorcontrib><creatorcontrib>Ghosh, Puja</creatorcontrib><creatorcontrib>Uzzaman, Md. Raihan</creatorcontrib><creatorcontrib>Sarker, Dipto Kumer</creatorcontrib><creatorcontrib>Zahura, Fatima Tuz</creatorcontrib><creatorcontrib>Uddin, Shaikh Jamal</creatorcontrib><creatorcontrib>Muhammad, Ilias</creatorcontrib><title>Hepatoprotective Plants from Bangladesh: A Biophytochemical Review and Future Prospect</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Liver diseases are quite prevalant in many densely populated countries, including Bangladesh. The liver and its hepatocytes are targeted by virus and microbes, as well as by chemical environmental toxicants, causing wide-spread disruption of metabolic fuctions of the human body, leading to death from end-stage liver diseases. The aim of this review is to systematically explore and record the potential of Bangladeshi ethnopharmacological plants to treat liver diseases with focus on their sources, constituents, and therapeutic uses, including mechanisms of actions (MoA). A literature survey was carried out using Pubmed, Google Scholar, ScienceDirect, and Scopus databases with articles reported until July, 2020. A total of 88 Bangladeshi hepatoprotective plants (BHPs) belonging to 47 families were listed in this review, including Euphorbiaceae, Cucurbitaceae, and Compositae families contained 20% of plants, while herbs were the most cited (51%) and leaves were the most consumed parts (23%) as surveyed. The effect of BHPs against different hepatotoxins was observed via upregulation of antioxidant systems and inhibition of lipid peroxidation which subsequently reduced the elevated liver biomarkers. Different active constituents, including phenolics, curcuminoids, cucurbitanes, terpenoids, fatty acids, carotenoids, and polysaccharides, have been reported from these plants. The hepatoameliorative effect of these constituents was mainly involved in the reduction of hepatic oxidative stress and inflammation through activation of Nrf2/HO-1 and inhibition of NF-κB signaling pathways. 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Raihan</au><au>Sarker, Dipto Kumer</au><au>Zahura, Fatima Tuz</au><au>Uddin, Shaikh Jamal</au><au>Muhammad, Ilias</au><au>Mediani, Ahmed</au><au>Ahmed Mediani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatoprotective Plants from Bangladesh: A Biophytochemical Review and Future Prospect</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>1633231</spage><epage>39</epage><pages>1633231-39</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Liver diseases are quite prevalant in many densely populated countries, including Bangladesh. The liver and its hepatocytes are targeted by virus and microbes, as well as by chemical environmental toxicants, causing wide-spread disruption of metabolic fuctions of the human body, leading to death from end-stage liver diseases. The aim of this review is to systematically explore and record the potential of Bangladeshi ethnopharmacological plants to treat liver diseases with focus on their sources, constituents, and therapeutic uses, including mechanisms of actions (MoA). A literature survey was carried out using Pubmed, Google Scholar, ScienceDirect, and Scopus databases with articles reported until July, 2020. A total of 88 Bangladeshi hepatoprotective plants (BHPs) belonging to 47 families were listed in this review, including Euphorbiaceae, Cucurbitaceae, and Compositae families contained 20% of plants, while herbs were the most cited (51%) and leaves were the most consumed parts (23%) as surveyed. The effect of BHPs against different hepatotoxins was observed via upregulation of antioxidant systems and inhibition of lipid peroxidation which subsequently reduced the elevated liver biomarkers. Different active constituents, including phenolics, curcuminoids, cucurbitanes, terpenoids, fatty acids, carotenoids, and polysaccharides, have been reported from these plants. The hepatoameliorative effect of these constituents was mainly involved in the reduction of hepatic oxidative stress and inflammation through activation of Nrf2/HO-1 and inhibition of NF-κB signaling pathways. In summary, BHPs represent a valuable resource for hepatoprotective lead therapeutics which may offer new alternatives to treat liver diseases.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34504532</pmid><doi>10.1155/2021/1633231</doi><tpages>39</tpages><orcidid>https://orcid.org/0000-0003-3163-2118</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Ascites Carotenoids Fatty acids Fruits Hepatitis Hepatocytes Hepatotoxicity Herbal medicine Lipid peroxidation Liver diseases Medicine NF-κB protein Oxidative stress Polysaccharides Review Reviews Seeds Toxicants Trees |
| title | Hepatoprotective Plants from Bangladesh: A Biophytochemical Review and Future Prospect |
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