Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model

Alzheimer's disease (AD) often coexists with other aging-associated diseases including obesity, diabetes, hypertension, and cardiovascular diseases. The early stage of these comorbidities is known as metabolic syndrome (MetS) which is highly prevalent in mid-life. An important cause of MetS is...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2020-10, Vol.1866 (10), p.165849-165849, Article 165849
Hauptverfasser:	Tyagi, Alpna, Mirita, Carol, Taher, Nadine, Shah, Iman, Moeller, Emily, Tyagi, Anit, Chong, Thomas, Pugazhenthi, Subbiah
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Amyloid - metabolism Amyloid pathology Amyloidosis - metabolism Amyloidosis - pathology Animals Brain - metabolism Disease Models, Animal Female Insulin Resistance Interleukin-1beta - metabolism Male Metabolic syndrome Metabolic Syndrome - metabolism Mice Microglia Microglia and Neuroinflammation Plaque, Amyloid - metabolism Plaque, Amyloid - pathology SIRT3 Sirtuin 3 - metabolism
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