Detailed Evaluation of Macular Ganglion Cell Complex in Patients with Multiple Sclerosis
Retinal nerve fiber layer thickness has been used for monitoring of disease activity in patients with multiple sclerosis (MS). Macular ganglion cell complex (GCC) layer of retina also can be measured by OCT and has been suggested as a potential biomarker in MS. In this study we investigated the macu...
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| Veröffentlicht in: | Archives of Neuropsychiatry 2021-09, Vol.58 (3), p.176-183 |
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| creator | Özbilen, Kemal Turgay Gündüz, Tuncay Kartal, Selva Nur Çukurova Ceylan, Nihan Aksu Eraksoy, Mefküre Kürtüncü, Murat |
| description | Retinal nerve fiber layer thickness has been used for monitoring of disease activity in patients with multiple sclerosis (MS). Macular ganglion cell complex (GCC) layer of retina also can be measured by OCT and has been suggested as a potential biomarker in MS. In this study we investigated the macular GCC and its role as a potential biomarker in patients with Multiple Sclerosis (MS).
A prospective cohort-study, subjects consisted of Relapsing-Remitting MS patients (n=62) and healthy controls (n=60). Eyes of MS patients were divided into two subgroups according to the history of the optic neuritis (ON). Standard peripapillary-RNFL and macular scan protocol, and retinal auto-segmentation of spectral-domain OCT were performed. Macular RNFL (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL), and GCC (the sum of these former three layers) were recorded. The macula was divided into nine sectors using the ETDRS grid (4×9=36 variables).
In total, 50 eyes of 36 patients had previous ON attacks. 35/36 GCC parameters were thinner in MS patients and subgroups compared to the control group (p |
| doi_str_mv | 10.29399/npa.27531 |
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A prospective cohort-study, subjects consisted of Relapsing-Remitting MS patients (n=62) and healthy controls (n=60). Eyes of MS patients were divided into two subgroups according to the history of the optic neuritis (ON). Standard peripapillary-RNFL and macular scan protocol, and retinal auto-segmentation of spectral-domain OCT were performed. Macular RNFL (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL), and GCC (the sum of these former three layers) were recorded. The macula was divided into nine sectors using the ETDRS grid (4×9=36 variables).
In total, 50 eyes of 36 patients had previous ON attacks. 35/36 GCC parameters were thinner in MS patients and subgroups compared to the control group (p<0.05). When the eyes with and without a history of optic neuritis were compared, 25 of 36 parameters were thinner in those with ON. There were strong correlations between visual acuity-GCC parameters and EDSS scores in patients with a history of optic neuritis. However, no such relationship was found in those without an ON story.
Ganglion cell complex gets thinner in patients with MS with a decreasing order of GCL, IPL, and mRNFL. The examination of GCC in detail could be a beneficial biomarker for MS.</description><identifier>ISSN: 1300-0667</identifier><identifier>ISSN: 1309-4866</identifier><identifier>EISSN: 1309-4866</identifier><identifier>DOI: 10.29399/npa.27531</identifier><identifier>PMID: 34526838</identifier><language>eng</language><publisher>Turkey: AVES</publisher><subject>Biomarkers ; Care and treatment ; Diabetic retinopathy ; Ganglion ; Multiple sclerosis ; Optics ; Patients ; Retina ; Software</subject><ispartof>Archives of Neuropsychiatry, 2021-09, Vol.58 (3), p.176-183</ispartof><rights>Copyright: © 2020 Turkish Neuropsychiatric Society.</rights><rights>COPYRIGHT 2021 AVES</rights><rights>Copyright BAYT Ltd. Co. Sep 2021</rights><rights>Copyright: © 2020 Turkish Neuropsychiatric Society 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-4a884e19a83a8644797ad8e8cd09ef0b1b886fdbb3d202645d24b2111ae0b0d03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419730/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419730/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34526838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Özbilen, Kemal Turgay</creatorcontrib><creatorcontrib>Gündüz, Tuncay</creatorcontrib><creatorcontrib>Kartal, Selva Nur Çukurova</creatorcontrib><creatorcontrib>Ceylan, Nihan Aksu</creatorcontrib><creatorcontrib>Eraksoy, Mefküre</creatorcontrib><creatorcontrib>Kürtüncü, Murat</creatorcontrib><title>Detailed Evaluation of Macular Ganglion Cell Complex in Patients with Multiple Sclerosis</title><title>Archives of Neuropsychiatry</title><addtitle>Noro Psikiyatr Ars</addtitle><description>Retinal nerve fiber layer thickness has been used for monitoring of disease activity in patients with multiple sclerosis (MS). Macular ganglion cell complex (GCC) layer of retina also can be measured by OCT and has been suggested as a potential biomarker in MS. In this study we investigated the macular GCC and its role as a potential biomarker in patients with Multiple Sclerosis (MS).
A prospective cohort-study, subjects consisted of Relapsing-Remitting MS patients (n=62) and healthy controls (n=60). Eyes of MS patients were divided into two subgroups according to the history of the optic neuritis (ON). Standard peripapillary-RNFL and macular scan protocol, and retinal auto-segmentation of spectral-domain OCT were performed. Macular RNFL (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL), and GCC (the sum of these former three layers) were recorded. The macula was divided into nine sectors using the ETDRS grid (4×9=36 variables).
In total, 50 eyes of 36 patients had previous ON attacks. 35/36 GCC parameters were thinner in MS patients and subgroups compared to the control group (p<0.05). When the eyes with and without a history of optic neuritis were compared, 25 of 36 parameters were thinner in those with ON. There were strong correlations between visual acuity-GCC parameters and EDSS scores in patients with a history of optic neuritis. However, no such relationship was found in those without an ON story.
Ganglion cell complex gets thinner in patients with MS with a decreasing order of GCL, IPL, and mRNFL. The examination of GCC in detail could be a beneficial biomarker for MS.</description><subject>Biomarkers</subject><subject>Care and treatment</subject><subject>Diabetic retinopathy</subject><subject>Ganglion</subject><subject>Multiple sclerosis</subject><subject>Optics</subject><subject>Patients</subject><subject>Retina</subject><subject>Software</subject><issn>1300-0667</issn><issn>1309-4866</issn><issn>1309-4866</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkl1rFDEUhgdR7Ife-AMkIIgIs-Zr8nEjlLVWoUVBBe_CmUxmNyWTrJOZWv-92W2tXZFcJOQ8503OOW9VPSN4QTXT-k3cwILKhpEH1SFhWNdcCfFwd8Y1FkIeVEc5X2IsmCLycXXAeEOFYuqw-v7OTeCD69DpFYQZJp8iSj26ADsHGNEZxFXY3i1dCGiZhk1w18hH9LmgLk4Z_fTTGl3MYfIlhL7Y4MaUfX5SPeohZPf0dj-uvr0__br8UJ9_Ovu4PDmvbYP5VHNQijuiQTFQgnOpJXTKKdth7XrcklYp0XdtyzqKqeBNR3lLCSHgcIs7zI6rtze6m7kdXGfLn0YIZjP6AcZfJoE3-5Ho12aVroziREu2FXh1KzCmH7PLkxl8tqVaiC7N2dBGMs4kprKgL_5BL9M8xlJeoTQjWuGm-UutIDjjY5_Ku3Yrak6ElIIKynWhFv-hyurc4G2Kri9T2U94eS9h7SBM65zCvJ1Y3gdf34C2DCKPrr9rBsFmZxhTDGN2hinw8_vtu0P_OIT9BiClucs</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Özbilen, Kemal Turgay</creator><creator>Gündüz, Tuncay</creator><creator>Kartal, Selva Nur Çukurova</creator><creator>Ceylan, Nihan Aksu</creator><creator>Eraksoy, Mefküre</creator><creator>Kürtüncü, Murat</creator><general>AVES</general><general>BAYT Ltd. Co</general><general>Noro-Psikiyatri Arsivi</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210901</creationdate><title>Detailed Evaluation of Macular Ganglion Cell Complex in Patients with Multiple Sclerosis</title><author>Özbilen, Kemal Turgay ; Gündüz, Tuncay ; Kartal, Selva Nur Çukurova ; Ceylan, Nihan Aksu ; Eraksoy, Mefküre ; Kürtüncü, Murat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-4a884e19a83a8644797ad8e8cd09ef0b1b886fdbb3d202645d24b2111ae0b0d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers</topic><topic>Care and treatment</topic><topic>Diabetic retinopathy</topic><topic>Ganglion</topic><topic>Multiple sclerosis</topic><topic>Optics</topic><topic>Patients</topic><topic>Retina</topic><topic>Software</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Özbilen, Kemal Turgay</creatorcontrib><creatorcontrib>Gündüz, Tuncay</creatorcontrib><creatorcontrib>Kartal, Selva Nur Çukurova</creatorcontrib><creatorcontrib>Ceylan, Nihan Aksu</creatorcontrib><creatorcontrib>Eraksoy, Mefküre</creatorcontrib><creatorcontrib>Kürtüncü, Murat</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of Neuropsychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özbilen, Kemal Turgay</au><au>Gündüz, Tuncay</au><au>Kartal, Selva Nur Çukurova</au><au>Ceylan, Nihan Aksu</au><au>Eraksoy, Mefküre</au><au>Kürtüncü, Murat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detailed Evaluation of Macular Ganglion Cell Complex in Patients with Multiple Sclerosis</atitle><jtitle>Archives of Neuropsychiatry</jtitle><addtitle>Noro Psikiyatr Ars</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>58</volume><issue>3</issue><spage>176</spage><epage>183</epage><pages>176-183</pages><issn>1300-0667</issn><issn>1309-4866</issn><eissn>1309-4866</eissn><abstract>Retinal nerve fiber layer thickness has been used for monitoring of disease activity in patients with multiple sclerosis (MS). Macular ganglion cell complex (GCC) layer of retina also can be measured by OCT and has been suggested as a potential biomarker in MS. In this study we investigated the macular GCC and its role as a potential biomarker in patients with Multiple Sclerosis (MS).
A prospective cohort-study, subjects consisted of Relapsing-Remitting MS patients (n=62) and healthy controls (n=60). Eyes of MS patients were divided into two subgroups according to the history of the optic neuritis (ON). Standard peripapillary-RNFL and macular scan protocol, and retinal auto-segmentation of spectral-domain OCT were performed. Macular RNFL (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL), and GCC (the sum of these former three layers) were recorded. The macula was divided into nine sectors using the ETDRS grid (4×9=36 variables).
In total, 50 eyes of 36 patients had previous ON attacks. 35/36 GCC parameters were thinner in MS patients and subgroups compared to the control group (p<0.05). When the eyes with and without a history of optic neuritis were compared, 25 of 36 parameters were thinner in those with ON. There were strong correlations between visual acuity-GCC parameters and EDSS scores in patients with a history of optic neuritis. However, no such relationship was found in those without an ON story.
Ganglion cell complex gets thinner in patients with MS with a decreasing order of GCL, IPL, and mRNFL. The examination of GCC in detail could be a beneficial biomarker for MS.</abstract><cop>Turkey</cop><pub>AVES</pub><pmid>34526838</pmid><doi>10.29399/npa.27531</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biomarkers Care and treatment Diabetic retinopathy Ganglion Multiple sclerosis Optics Patients Retina Software |
| title | Detailed Evaluation of Macular Ganglion Cell Complex in Patients with Multiple Sclerosis |
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