Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features
This study aims to investigate the relationship between estrogen receptors (ERs) and progesterone receptors (PRs) and histopathological findings in synovial tissue in rheumatoid arthritis (RA) and osteoarthritis (OA) patients. Synovial tissue samples obtained from synovial surgery from 30 RA (10 mal...
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| Veröffentlicht in: | Archives of rheumatology 2021-06, Vol.36 (2), p.192-200 |
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| description | This study aims to investigate the relationship between estrogen receptors (ERs) and progesterone receptors (PRs) and histopathological findings in synovial tissue in rheumatoid arthritis (RA) and osteoarthritis (OA) patients.
Synovial tissue samples obtained from synovial surgery from 30 RA (10 males, 20 females) and 92 OA (27 males, 65 females) patients with median age of 59 (range, 50 to 67) years were analyzed retrospectively between January 2010 and January 2019. The relationship between histopathological features and hormone receptor presence was analyzed.
There was a meaningful relationship between histopathological parameters and RA and OA (p=0.01). The sex hormone receptor's presence was significantly higher in females with RA (p=0.01). Additionally, in the RA group, there was a remarkable relationship between ER and focal aggregates of lymphocytes (p=0.01), perivascular infiltrates of lymphocytes (p=0.03), and diffuse infiltrates of lymphocytes (p=0.01). In the OA group, a significant relationship was observed between PR and subchondral inflammation (p=0.01). In multivariate analysis, it was observed that ER was an independent risk factor for focal aggregates of lymphocytes in RA group (odds ratio [OR]=1.51 [1.02-2.25], p=0.04). Besides, PR was found to be an independent risk factor for subchondral inflammation in OA group (OR=3.90 [1.28-11.80], p=0.02).
The presence of the sex hormone receptor in the synovium may change histopathological features and affect the clinical course. |
| doi_str_mv | 10.46497/ArchRheumatol.2021.8242 |
| format | Article |
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Synovial tissue samples obtained from synovial surgery from 30 RA (10 males, 20 females) and 92 OA (27 males, 65 females) patients with median age of 59 (range, 50 to 67) years were analyzed retrospectively between January 2010 and January 2019. The relationship between histopathological features and hormone receptor presence was analyzed.
There was a meaningful relationship between histopathological parameters and RA and OA (p=0.01). The sex hormone receptor's presence was significantly higher in females with RA (p=0.01). Additionally, in the RA group, there was a remarkable relationship between ER and focal aggregates of lymphocytes (p=0.01), perivascular infiltrates of lymphocytes (p=0.03), and diffuse infiltrates of lymphocytes (p=0.01). In the OA group, a significant relationship was observed between PR and subchondral inflammation (p=0.01). In multivariate analysis, it was observed that ER was an independent risk factor for focal aggregates of lymphocytes in RA group (odds ratio [OR]=1.51 [1.02-2.25], p=0.04). Besides, PR was found to be an independent risk factor for subchondral inflammation in OA group (OR=3.90 [1.28-11.80], p=0.02).
The presence of the sex hormone receptor in the synovium may change histopathological features and affect the clinical course.</description><identifier>ISSN: 2148-5046</identifier><identifier>ISSN: 1309-0291</identifier><identifier>EISSN: 2618-6500</identifier><identifier>EISSN: 1309-0283</identifier><identifier>DOI: 10.46497/ArchRheumatol.2021.8242</identifier><identifier>PMID: 34527923</identifier><language>eng</language><publisher>Turkey: Turkish League Against Rheumatism</publisher><subject>Age ; Archives & records ; Biopsy ; Blood vessels ; Cartilage ; Cloning ; Comparative analysis ; Estrogen ; Estrogens ; Health aspects ; Hormones ; Hyperplasia ; Inflammation ; Lymphocytes ; Multivariate analysis ; Original ; Osteoarthritis ; Pathology ; Patients ; Progesterone ; Rheumatoid arthritis ; Rheumatoid factor ; Risk factors ; Statistical analysis ; Women</subject><ispartof>Archives of rheumatology, 2021-06, Vol.36 (2), p.192-200</ispartof><rights>Copyright © 2021, Turkish League Against Rheumatism.</rights><rights>COPYRIGHT 2021 Turkish League Against Rheumatism</rights><rights>Copyright Prof Sebnem Ataman, President Turkish League Against Rheumatism 2021</rights><rights>Copyright © 2021, Turkish League Against Rheumatism 2021 Turkish League Against Rheumatism</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c546t-9b321e4c3763f5ed3a6d4ac58002a0ebde5617a6b42c8f15ca918490dcade8d3</citedby><orcidid>0000-0002-2420-5153 ; 0000-0003-1937-2771</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418768/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418768/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34527923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kültür, Turgut</creatorcontrib><creatorcontrib>Zengin, Mehmet</creatorcontrib><title>Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features</title><title>Archives of rheumatology</title><addtitle>Arch Rheumatol</addtitle><description>This study aims to investigate the relationship between estrogen receptors (ERs) and progesterone receptors (PRs) and histopathological findings in synovial tissue in rheumatoid arthritis (RA) and osteoarthritis (OA) patients.
Synovial tissue samples obtained from synovial surgery from 30 RA (10 males, 20 females) and 92 OA (27 males, 65 females) patients with median age of 59 (range, 50 to 67) years were analyzed retrospectively between January 2010 and January 2019. The relationship between histopathological features and hormone receptor presence was analyzed.
There was a meaningful relationship between histopathological parameters and RA and OA (p=0.01). The sex hormone receptor's presence was significantly higher in females with RA (p=0.01). Additionally, in the RA group, there was a remarkable relationship between ER and focal aggregates of lymphocytes (p=0.01), perivascular infiltrates of lymphocytes (p=0.03), and diffuse infiltrates of lymphocytes (p=0.01). In the OA group, a significant relationship was observed between PR and subchondral inflammation (p=0.01). In multivariate analysis, it was observed that ER was an independent risk factor for focal aggregates of lymphocytes in RA group (odds ratio [OR]=1.51 [1.02-2.25], p=0.04). Besides, PR was found to be an independent risk factor for subchondral inflammation in OA group (OR=3.90 [1.28-11.80], p=0.02).
The presence of the sex hormone receptor in the synovium may change histopathological features and affect the clinical course.</description><subject>Age</subject><subject>Archives & records</subject><subject>Biopsy</subject><subject>Blood vessels</subject><subject>Cartilage</subject><subject>Cloning</subject><subject>Comparative analysis</subject><subject>Estrogen</subject><subject>Estrogens</subject><subject>Health aspects</subject><subject>Hormones</subject><subject>Hyperplasia</subject><subject>Inflammation</subject><subject>Lymphocytes</subject><subject>Multivariate analysis</subject><subject>Original</subject><subject>Osteoarthritis</subject><subject>Pathology</subject><subject>Patients</subject><subject>Progesterone</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Risk factors</subject><subject>Statistical analysis</subject><subject>Women</subject><issn>2148-5046</issn><issn>1309-0291</issn><issn>2618-6500</issn><issn>1309-0283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkl1rFDEUhgdRbKn9CxIQvNs135O5EZaiVigo0vtwNnNmJ2VmMiYZP-794Wa7a9sFc5Nw8j4v5xzeqiKMrqWWTf1uE13_rcdlhByGNaecrQ2X_Fl1zjUzK60ofV7eTJqVolKfVZcp3VFKmay1puJldSak4nXDxXn15ytkj1NO5KfPPYlHW98SiLmPPvtEYGpJSBnDY8lPJGMcEwkdSfiL9CGOYUIS0eGcQzxAvU85zJD7MISddzAQF8YZok9h2pMdQl4iplfViw6GhJfH-6K6_fjh9up6dfPl0-erzc3KKanzqtkKzlA6UWvRKWwF6FaCU4ZSDhS3LSrNatBbyZ3pmHLQMCMb2jpo0bTionp_sJ2X7YitK2NHGOwc_Qjxtw3g7enP5Hu7Cz-skczU2hSDN0eDGL4vmLK9C0ucSsuWK21qLpRpHlU7GND6qQvFzI0-ObvR5dSs5nVRrf-jgn2ro3dll50v9RPg7ROgRxhyn8KwZB-mdCo0B6GLIaWI3cOEjNr7BNmTBNl9guw-QQV9_XRDD-C_vIi_rQXJTQ</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Kültür, Turgut</creator><creator>Zengin, Mehmet</creator><general>Turkish League Against Rheumatism</general><general>Prof Sebnem Ataman, President Turkish League Against Rheumatism</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2420-5153</orcidid><orcidid>https://orcid.org/0000-0003-1937-2771</orcidid></search><sort><creationdate>20210601</creationdate><title>Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features</title><author>Kültür, Turgut ; Zengin, Mehmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-9b321e4c3763f5ed3a6d4ac58002a0ebde5617a6b42c8f15ca918490dcade8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Archives & records</topic><topic>Biopsy</topic><topic>Blood vessels</topic><topic>Cartilage</topic><topic>Cloning</topic><topic>Comparative analysis</topic><topic>Estrogen</topic><topic>Estrogens</topic><topic>Health aspects</topic><topic>Hormones</topic><topic>Hyperplasia</topic><topic>Inflammation</topic><topic>Lymphocytes</topic><topic>Multivariate analysis</topic><topic>Original</topic><topic>Osteoarthritis</topic><topic>Pathology</topic><topic>Patients</topic><topic>Progesterone</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Risk factors</topic><topic>Statistical analysis</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kültür, Turgut</creatorcontrib><creatorcontrib>Zengin, Mehmet</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Turkey Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kültür, Turgut</au><au>Zengin, Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features</atitle><jtitle>Archives of rheumatology</jtitle><addtitle>Arch Rheumatol</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>36</volume><issue>2</issue><spage>192</spage><epage>200</epage><pages>192-200</pages><issn>2148-5046</issn><issn>1309-0291</issn><eissn>2618-6500</eissn><eissn>1309-0283</eissn><abstract>This study aims to investigate the relationship between estrogen receptors (ERs) and progesterone receptors (PRs) and histopathological findings in synovial tissue in rheumatoid arthritis (RA) and osteoarthritis (OA) patients.
Synovial tissue samples obtained from synovial surgery from 30 RA (10 males, 20 females) and 92 OA (27 males, 65 females) patients with median age of 59 (range, 50 to 67) years were analyzed retrospectively between January 2010 and January 2019. The relationship between histopathological features and hormone receptor presence was analyzed.
There was a meaningful relationship between histopathological parameters and RA and OA (p=0.01). The sex hormone receptor's presence was significantly higher in females with RA (p=0.01). Additionally, in the RA group, there was a remarkable relationship between ER and focal aggregates of lymphocytes (p=0.01), perivascular infiltrates of lymphocytes (p=0.03), and diffuse infiltrates of lymphocytes (p=0.01). In the OA group, a significant relationship was observed between PR and subchondral inflammation (p=0.01). In multivariate analysis, it was observed that ER was an independent risk factor for focal aggregates of lymphocytes in RA group (odds ratio [OR]=1.51 [1.02-2.25], p=0.04). Besides, PR was found to be an independent risk factor for subchondral inflammation in OA group (OR=3.90 [1.28-11.80], p=0.02).
The presence of the sex hormone receptor in the synovium may change histopathological features and affect the clinical course.</abstract><cop>Turkey</cop><pub>Turkish League Against Rheumatism</pub><pmid>34527923</pmid><doi>10.46497/ArchRheumatol.2021.8242</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2420-5153</orcidid><orcidid>https://orcid.org/0000-0003-1937-2771</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of rheumatology, 2021-06, Vol.36 (2), p.192-200 |
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| source | PubMed Central; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Age Archives & records Biopsy Blood vessels Cartilage Cloning Comparative analysis Estrogen Estrogens Health aspects Hormones Hyperplasia Inflammation Lymphocytes Multivariate analysis Original Osteoarthritis Pathology Patients Progesterone Rheumatoid arthritis Rheumatoid factor Risk factors Statistical analysis Women |
| title | Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features |
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