Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies

A bstract Bipolar disorder (BD) is a neuropsychiatric illness defined by recurrent episodes of mania/hypomania, depression and circadian rhythm abnormalities. Lithium is an effective drug for BD, but 30–40% of patients fail to respond adequately to treatment. Previous work has demonstrated that lith...

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Veröffentlicht in:	Molecular psychiatry 2021-07, Vol.26 (7), p.3383-3394
Hauptverfasser:	Mishra, Himanshu K., Ying, Noelle M., Luis, Angelica, Wei, Heather, Nguyen, Metta, Nakhla, Timothy, Vandenburgh, Sara, Alda, Martin, Berrettini, Wade H., Brennand, Kristen J., Calabrese, Joseph R., Coryell, William H., Frye, Mark A., Gage, Fred H., Gershon, Elliot S., McInnis, Melvin G., Nievergelt, Caroline M., Nurnberger, John I., Shilling, Paul D., Oedegaard, Ketil J., Zandi, Peter P., Kelsoe, John R., Welsh, David K., McCarthy, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/106 14 14/5 38 38/77 631/378 631/80 82/1 Affective disorders Behavioral Sciences Biological Psychology Bipolar disorder Bipolar Disorder - drug therapy Cell culture Circadian Rhythm Circadian rhythms Entrainment Glutamatergic transmission Health aspects Humans Inhibitory postsynaptic potentials Lithium Lithium - pharmacology Lithium Compounds - pharmacology Medicine Medicine & Public Health Mental disorders Neurons Neurosciences Patients Period 2 protein Pharmacotherapy Physiological aspects Pluripotency Psychiatry Psychological aspects Stem cells Synchronization
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