Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis

Dysregulated long non-coding RNAs (lncRNAs) have been shown to contribute to the pathogenesis of ischemic stroke. However, the potential role of lncRNAs in post-stroke microglial activation remains largely unknown. Here, we uncovered that lncRNA-U90926 was significantly increased in microglia expose...

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Veröffentlicht in:	Molecular therapy 2021-09, Vol.29 (9), p.2873-2885
Hauptverfasser:	Chen, Jian, Jin, Jiali, Zhang, Xi, Yu, Hailong, Zhu, Xiaolei, Yu, Linjie, Chen, Yanting, Liu, Pinyi, Dong, Xiaohong, Cao, Xiang, Gu, Yue, Bao, Xinyu, Xia, Shengnan, Xu, Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Animals Cells, Cultured Chemokine CXCL2 - genetics CXCL2 Disease Models, Animal HEK293 Cells Humans ischemic stroke Ischemic Stroke - genetics Ischemic Stroke - immunology Malate Dehydrogenase - genetics Male MDH2 Mice Mice, Inbred C57BL microglia Microglia - chemistry neutrophil Neutrophil Infiltration Original Primary Cell Culture RNA, Long Noncoding - genetics U90926 Up-Regulation
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