Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells

Bladder carcinoma is among the top 10 most frequently diagnosed cancer types in the world. As a phytochemical active metabolic, thymoquinone (TQ) is extracted from seeds of Nigella sativa, possessing various biological properties in a wide range of diseases. Moreover, the outstanding anti-cancer eff...

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Veröffentlicht in:	International journal of biological sciences 2021-01, Vol.17 (13), p.3456-3475
Hauptverfasser:	Zhou, Xuejian, Wang, Feifan, Wu, Hongshen, Chen, Xianwu, Zhang, Yan, Lin, Juntao, Cai, Yueshu, Xiang, Jiayong, He, Ning, Hu, Zhenghui, Jin, Xiaodong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Anticancer properties Apoptosis Autophagy Autophagy - drug effects B7-H1 Antigen - metabolism Benzoquinones - pharmacology Benzoquinones - therapeutic use Biological properties Bladder Bladder cancer Breast cancer Carcinoma - drug therapy Carcinoma - metabolism Caspase Cell Line, Tumor Cell proliferation Clinical outcomes Drug Evaluation, Preclinical Epithelial-Mesenchymal Transition - drug effects Homeostasis Humans Invasiveness Lysosomes Medical research Membrane potential Membrane Potential, Mitochondrial - drug effects Mesenchyme MicroRNAs MicroRNAs - metabolism miRNA Mitochondria PD-L1 protein Phagocytosis Phagosomes Phytochemicals Reactive oxygen species Reactive Oxygen Species - metabolism Research Paper Seeds Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - metabolism
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