Endophilin A2-mediated alleviation of endoplasmic reticulum stress-induced cardiac injury involves the suppression of ERO1α/IP3R signaling pathway

Cardiac injury upon myocardial infarction (MI) is the leading cause of heart failure. The present study aims to investigate the role of EndoA2 in ischemia-induced cardiomyocyte apoptosis and cardiac injury. In vivo, we established an MI mouse model by ligating the left anterior descending (LAD) coro...

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Veröffentlicht in:	International journal of biological sciences 2021-01, Vol.17 (13), p.3672-3688
Hauptverfasser:	Liu, Yun, Hu, Ruixiang, Shen, Huanjia, Mo, Qinxin, Wang, Xinqiuyue, Zhang, Guiping, Li, Sujuan, Liang, Guanfeng, Hou, Ning, Luo, Jiandong
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Apoptosis Attenuation Calcineurin Calcineurin inhibitors Calcium (intracellular) Calcium ions Cardiac function Cardiomyocytes Congestive heart failure Coronary artery Coronary vessels Cyclosporin A Dephosphorylation Deprivation Endoplasmic reticulum Ethane Glucose Heart attacks Heart failure Homeostasis Inhibitors Injection Injury prevention Inositol 1,4,5-trisphosphate receptors Intracellular Ischemia Ligands Myocardial infarction Neonates NF-AT protein Oxidoreductase Pretreatment Proteins Research Paper Signal transduction Signaling siRNA Sodium Transfection Veins & arteries
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