Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics

The autophagy‑lysosome system allows cells to adapt to environmental changes by regulating the degradation and recycling of cellular components, and to maintain homeostasis by removing aggregated proteins and defective organelles. Cyclin G‑associated kinase (GAK) is involved in the regulation of cla...

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Veröffentlicht in:	International journal of molecular medicine 2021-10, Vol.48 (4), p.1, Article 195
Hauptverfasser:	Miyazaki, Masaya, Hiramoto, Masaki, Takano, Naoharu, Kokuba, Hiroko, Takemura, Jun, Tokuhisa, Mayumi, Hino, Hirotsugu, Kazama, Hiromi, Miyazawa, Keisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Actomyosin - metabolism Amino acids Antibodies Autophagosomes - metabolism Autophagy Autophagy - physiology Biotechnology industry Cancer Cell cycle Cloning CRISPR Genetic aspects Genomes Genomics Homeostasis Humans Intracellular Signaling Peptides and Proteins - metabolism Kinases Laboratories Lysosomes - metabolism Pharmaceutical industry Protein kinases Protein Serine-Threonine Kinases - metabolism Proteins rho-Associated Kinases - metabolism Scientific equipment and supplies industry Single nucleotide polymorphisms
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