Associations of serum transthyretin with triglyceride in non-obese elderly Japanese women independently of insulin resistance, HDL cholesterol, and adiponectin
Objective Studies are limited on the association between serum transthyretin (TTR), a negative acute phase reactant, and triglyceride (TG). Research design and methods TG, TTR, and insulin resistance-related cardiometabolic variables were measured in 159 fasting and 185 nonfasting community-dwelling...
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| Veröffentlicht in: | Diabetology International 2021-10, Vol.12 (4), p.405-411 |
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| creator | Minato-Inokawa, Satomi Tsuboi, Ayaka Takeuchi, Mika Kitaoka, Kaori Yano, Megumu Kurata, Miki Kazumi, Tsutomu Fukuo, Keisuke |
| description | Objective
Studies are limited on the association between serum transthyretin (TTR), a negative acute phase reactant, and triglyceride (TG).
Research design and methods
TG, TTR, and insulin resistance-related cardiometabolic variables were measured in 159 fasting and 185 nonfasting community-dwelling elderly women aged 50–96 years. Pearson correlation analysis and then stepwise multiple regression analyses were performed to further identify the most significant variables contributing to the variation of fasting and nonfasting TG.
Results
Multiple regression analysis for fasting TG as a dependent variable revealed that TTR (standardized β: 0.299) and HDL cholesterol (standardized β: -0.545) emerged as determinants of TG independently of percentage of body fat, homeostasis model assessment insulin resistance, serum leptin and adiponectin, and plasminogen activator inhibitor-1 (PAI-1) (
R
2
= 0.36). For nonfasting TG, HDL cholesterol (standardized
β
: − 0.461), TTR (standardized
β
: 0.231), nonfasting insulin, a marker of insulin resistance, (standardized
β
: 0.202), and PAI-1 (standardized
β
: 0.187) emerged as determinants independently of percentage of body fat, nonfasting glucose, serum leptin and adiponectin, and high-sensitivity C-reactive protein (
R
2
= 0.45).
Conclusions
Fasting and nonfasting TG showed positive association with TTR in community-dwelling elderly non-obese women independently of insulin resistance, HDL cholesterol, and adiponectin. These findings may provide a clue as to a physiological function of circulating TTR in human: an influence factor of TG-rich lipoproteins in the circulation. |
| doi_str_mv | 10.1007/s13340-021-00496-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8413415</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A711675724</galeid><sourcerecordid>A711675724</sourcerecordid><originalsourceid>FETCH-LOGICAL-c550t-3b4d3d63518c963675d6b929840db35c967b37d1586a16ca3900bb34573e21993</originalsourceid><addsrcrecordid>eNp9Uk1v1DAQjRCIVqV_gAOyxIVDU-w4sZML0qpAC1qJC5wtx57sunLsYCdU-2v4q8x22-XjgCIl0Zv3nmfGryheMnrJKJVvM-O8piWtWElp3YmyflKcVqyjJROteHr8l-1JcZ7zLaV7GqNSPC9OeN0I2VX8tPi5yjkap2cXQyZxIBnSMpI56ZDn7S7B7AK5c_MWIbfxOwPJWSAIhhjK2EMGAt5C8jvyWU867IG7OEJAjoUJ8BVmLKK1C3nxqEyQXZ51MHBBbt6vidlGD3mGFP0F0cESbd0UAxg8-0XxbNA-w_nD96z49vHD16ubcv3l-tPVal2apqFzyfvacit4w1rTCS5kY0XfVV1bU9vzBjHZc2lZ0wrNhNG8o7TvcQ2SAy6q42fFu4PvtPQjWINNJ-3VlNyo005F7dTfleC2ahN_qLZmvGYNGrx5MEjx-4LjqNFlA97jSuKSVdVI0VHR3lNf_0O9jUsKOB6y8PIEpW2NrMsDa6M9KBeGiOcafCyMzuB6Bof4SjK840ZWe0F1EJgUc04wHLtnVO0zow6ZUZgZdZ8ZtRe9-nPuo-QxIUjgB0LGUthA-t3sf2x_AY-OzzI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2568660084</pqid></control><display><type>article</type><title>Associations of serum transthyretin with triglyceride in non-obese elderly Japanese women independently of insulin resistance, HDL cholesterol, and adiponectin</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Minato-Inokawa, Satomi ; Tsuboi, Ayaka ; Takeuchi, Mika ; Kitaoka, Kaori ; Yano, Megumu ; Kurata, Miki ; Kazumi, Tsutomu ; Fukuo, Keisuke</creator><creatorcontrib>Minato-Inokawa, Satomi ; Tsuboi, Ayaka ; Takeuchi, Mika ; Kitaoka, Kaori ; Yano, Megumu ; Kurata, Miki ; Kazumi, Tsutomu ; Fukuo, Keisuke</creatorcontrib><description>Objective
Studies are limited on the association between serum transthyretin (TTR), a negative acute phase reactant, and triglyceride (TG).
Research design and methods
TG, TTR, and insulin resistance-related cardiometabolic variables were measured in 159 fasting and 185 nonfasting community-dwelling elderly women aged 50–96 years. Pearson correlation analysis and then stepwise multiple regression analyses were performed to further identify the most significant variables contributing to the variation of fasting and nonfasting TG.
Results
Multiple regression analysis for fasting TG as a dependent variable revealed that TTR (standardized β: 0.299) and HDL cholesterol (standardized β: -0.545) emerged as determinants of TG independently of percentage of body fat, homeostasis model assessment insulin resistance, serum leptin and adiponectin, and plasminogen activator inhibitor-1 (PAI-1) (
R
2
= 0.36). For nonfasting TG, HDL cholesterol (standardized
β
: − 0.461), TTR (standardized
β
: 0.231), nonfasting insulin, a marker of insulin resistance, (standardized
β
: 0.202), and PAI-1 (standardized
β
: 0.187) emerged as determinants independently of percentage of body fat, nonfasting glucose, serum leptin and adiponectin, and high-sensitivity C-reactive protein (
R
2
= 0.45).
Conclusions
Fasting and nonfasting TG showed positive association with TTR in community-dwelling elderly non-obese women independently of insulin resistance, HDL cholesterol, and adiponectin. These findings may provide a clue as to a physiological function of circulating TTR in human: an influence factor of TG-rich lipoproteins in the circulation.</description><identifier>ISSN: 2190-1678</identifier><identifier>EISSN: 2190-1686</identifier><identifier>DOI: 10.1007/s13340-021-00496-4</identifier><identifier>PMID: 34567923</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Adiponectin ; Analysis ; Blood cholesterol ; Body fat ; C-reactive protein ; Cholesterol ; Correlation analysis ; Diabetes ; Endocrinology ; High density lipoprotein ; Homeostasis ; Insulin ; Insulin resistance ; Leptin ; Lipoproteins ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Multiple regression analysis ; Obesity ; Older people ; Original ; Original Article ; Physiological aspects ; Plasminogen activator inhibitors ; Transthyretin ; Triglycerides ; Women ; Womens health</subject><ispartof>Diabetology International, 2021-10, Vol.12 (4), p.405-411</ispartof><rights>The Japan Diabetes Society 2021</rights><rights>The Japan Diabetes Society 2021.</rights><rights>COPYRIGHT 2021 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c550t-3b4d3d63518c963675d6b929840db35c967b37d1586a16ca3900bb34573e21993</cites><orcidid>0000-0002-8855-9268</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413415/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413415/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34567923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minato-Inokawa, Satomi</creatorcontrib><creatorcontrib>Tsuboi, Ayaka</creatorcontrib><creatorcontrib>Takeuchi, Mika</creatorcontrib><creatorcontrib>Kitaoka, Kaori</creatorcontrib><creatorcontrib>Yano, Megumu</creatorcontrib><creatorcontrib>Kurata, Miki</creatorcontrib><creatorcontrib>Kazumi, Tsutomu</creatorcontrib><creatorcontrib>Fukuo, Keisuke</creatorcontrib><title>Associations of serum transthyretin with triglyceride in non-obese elderly Japanese women independently of insulin resistance, HDL cholesterol, and adiponectin</title><title>Diabetology International</title><addtitle>Diabetol Int</addtitle><addtitle>Diabetol Int</addtitle><description>Objective
Studies are limited on the association between serum transthyretin (TTR), a negative acute phase reactant, and triglyceride (TG).
Research design and methods
TG, TTR, and insulin resistance-related cardiometabolic variables were measured in 159 fasting and 185 nonfasting community-dwelling elderly women aged 50–96 years. Pearson correlation analysis and then stepwise multiple regression analyses were performed to further identify the most significant variables contributing to the variation of fasting and nonfasting TG.
Results
Multiple regression analysis for fasting TG as a dependent variable revealed that TTR (standardized β: 0.299) and HDL cholesterol (standardized β: -0.545) emerged as determinants of TG independently of percentage of body fat, homeostasis model assessment insulin resistance, serum leptin and adiponectin, and plasminogen activator inhibitor-1 (PAI-1) (
R
2
= 0.36). For nonfasting TG, HDL cholesterol (standardized
β
: − 0.461), TTR (standardized
β
: 0.231), nonfasting insulin, a marker of insulin resistance, (standardized
β
: 0.202), and PAI-1 (standardized
β
: 0.187) emerged as determinants independently of percentage of body fat, nonfasting glucose, serum leptin and adiponectin, and high-sensitivity C-reactive protein (
R
2
= 0.45).
Conclusions
Fasting and nonfasting TG showed positive association with TTR in community-dwelling elderly non-obese women independently of insulin resistance, HDL cholesterol, and adiponectin. These findings may provide a clue as to a physiological function of circulating TTR in human: an influence factor of TG-rich lipoproteins in the circulation.</description><subject>Adiponectin</subject><subject>Analysis</subject><subject>Blood cholesterol</subject><subject>Body fat</subject><subject>C-reactive protein</subject><subject>Cholesterol</subject><subject>Correlation analysis</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>High density lipoprotein</subject><subject>Homeostasis</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Leptin</subject><subject>Lipoproteins</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Multiple regression analysis</subject><subject>Obesity</subject><subject>Older people</subject><subject>Original</subject><subject>Original Article</subject><subject>Physiological aspects</subject><subject>Plasminogen activator inhibitors</subject><subject>Transthyretin</subject><subject>Triglycerides</subject><subject>Women</subject><subject>Womens health</subject><issn>2190-1678</issn><issn>2190-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9Uk1v1DAQjRCIVqV_gAOyxIVDU-w4sZML0qpAC1qJC5wtx57sunLsYCdU-2v4q8x22-XjgCIl0Zv3nmfGryheMnrJKJVvM-O8piWtWElp3YmyflKcVqyjJROteHr8l-1JcZ7zLaV7GqNSPC9OeN0I2VX8tPi5yjkap2cXQyZxIBnSMpI56ZDn7S7B7AK5c_MWIbfxOwPJWSAIhhjK2EMGAt5C8jvyWU867IG7OEJAjoUJ8BVmLKK1C3nxqEyQXZ51MHBBbt6vidlGD3mGFP0F0cESbd0UAxg8-0XxbNA-w_nD96z49vHD16ubcv3l-tPVal2apqFzyfvacit4w1rTCS5kY0XfVV1bU9vzBjHZc2lZ0wrNhNG8o7TvcQ2SAy6q42fFu4PvtPQjWINNJ-3VlNyo005F7dTfleC2ahN_qLZmvGYNGrx5MEjx-4LjqNFlA97jSuKSVdVI0VHR3lNf_0O9jUsKOB6y8PIEpW2NrMsDa6M9KBeGiOcafCyMzuB6Bof4SjK840ZWe0F1EJgUc04wHLtnVO0zow6ZUZgZdZ8ZtRe9-nPuo-QxIUjgB0LGUthA-t3sf2x_AY-OzzI</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Minato-Inokawa, Satomi</creator><creator>Tsuboi, Ayaka</creator><creator>Takeuchi, Mika</creator><creator>Kitaoka, Kaori</creator><creator>Yano, Megumu</creator><creator>Kurata, Miki</creator><creator>Kazumi, Tsutomu</creator><creator>Fukuo, Keisuke</creator><general>Springer Singapore</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8855-9268</orcidid></search><sort><creationdate>20211001</creationdate><title>Associations of serum transthyretin with triglyceride in non-obese elderly Japanese women independently of insulin resistance, HDL cholesterol, and adiponectin</title><author>Minato-Inokawa, Satomi ; Tsuboi, Ayaka ; Takeuchi, Mika ; Kitaoka, Kaori ; Yano, Megumu ; Kurata, Miki ; Kazumi, Tsutomu ; Fukuo, Keisuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-3b4d3d63518c963675d6b929840db35c967b37d1586a16ca3900bb34573e21993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adiponectin</topic><topic>Analysis</topic><topic>Blood cholesterol</topic><topic>Body fat</topic><topic>C-reactive protein</topic><topic>Cholesterol</topic><topic>Correlation analysis</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>High density lipoprotein</topic><topic>Homeostasis</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Leptin</topic><topic>Lipoproteins</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Multiple regression analysis</topic><topic>Obesity</topic><topic>Older people</topic><topic>Original</topic><topic>Original Article</topic><topic>Physiological aspects</topic><topic>Plasminogen activator inhibitors</topic><topic>Transthyretin</topic><topic>Triglycerides</topic><topic>Women</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minato-Inokawa, Satomi</creatorcontrib><creatorcontrib>Tsuboi, Ayaka</creatorcontrib><creatorcontrib>Takeuchi, Mika</creatorcontrib><creatorcontrib>Kitaoka, Kaori</creatorcontrib><creatorcontrib>Yano, Megumu</creatorcontrib><creatorcontrib>Kurata, Miki</creatorcontrib><creatorcontrib>Kazumi, Tsutomu</creatorcontrib><creatorcontrib>Fukuo, Keisuke</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetology International</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minato-Inokawa, Satomi</au><au>Tsuboi, Ayaka</au><au>Takeuchi, Mika</au><au>Kitaoka, Kaori</au><au>Yano, Megumu</au><au>Kurata, Miki</au><au>Kazumi, Tsutomu</au><au>Fukuo, Keisuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of serum transthyretin with triglyceride in non-obese elderly Japanese women independently of insulin resistance, HDL cholesterol, and adiponectin</atitle><jtitle>Diabetology International</jtitle><stitle>Diabetol Int</stitle><addtitle>Diabetol Int</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>12</volume><issue>4</issue><spage>405</spage><epage>411</epage><pages>405-411</pages><issn>2190-1678</issn><eissn>2190-1686</eissn><abstract>Objective
Studies are limited on the association between serum transthyretin (TTR), a negative acute phase reactant, and triglyceride (TG).
Research design and methods
TG, TTR, and insulin resistance-related cardiometabolic variables were measured in 159 fasting and 185 nonfasting community-dwelling elderly women aged 50–96 years. Pearson correlation analysis and then stepwise multiple regression analyses were performed to further identify the most significant variables contributing to the variation of fasting and nonfasting TG.
Results
Multiple regression analysis for fasting TG as a dependent variable revealed that TTR (standardized β: 0.299) and HDL cholesterol (standardized β: -0.545) emerged as determinants of TG independently of percentage of body fat, homeostasis model assessment insulin resistance, serum leptin and adiponectin, and plasminogen activator inhibitor-1 (PAI-1) (
R
2
= 0.36). For nonfasting TG, HDL cholesterol (standardized
β
: − 0.461), TTR (standardized
β
: 0.231), nonfasting insulin, a marker of insulin resistance, (standardized
β
: 0.202), and PAI-1 (standardized
β
: 0.187) emerged as determinants independently of percentage of body fat, nonfasting glucose, serum leptin and adiponectin, and high-sensitivity C-reactive protein (
R
2
= 0.45).
Conclusions
Fasting and nonfasting TG showed positive association with TTR in community-dwelling elderly non-obese women independently of insulin resistance, HDL cholesterol, and adiponectin. These findings may provide a clue as to a physiological function of circulating TTR in human: an influence factor of TG-rich lipoproteins in the circulation.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>34567923</pmid><doi>10.1007/s13340-021-00496-4</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8855-9268</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Adiponectin Analysis Blood cholesterol Body fat C-reactive protein Cholesterol Correlation analysis Diabetes Endocrinology High density lipoprotein Homeostasis Insulin Insulin resistance Leptin Lipoproteins Medicine Medicine & Public Health Metabolic Diseases Multiple regression analysis Obesity Older people Original Original Article Physiological aspects Plasminogen activator inhibitors Transthyretin Triglycerides Women Womens health |
| title | Associations of serum transthyretin with triglyceride in non-obese elderly Japanese women independently of insulin resistance, HDL cholesterol, and adiponectin |
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