Deaths Attributed to Respiratory Syncytial Virus in Young Children in High–Mortality Rate Settings: Report from Child Health and Mortality Prevention Surveillance (CHAMPS)
Abstract Background Lower respiratory tract infections are a leading cause of death in young children, but few studies have collected the specimens needed to define the role of specific causes. The Child Health and Mortality Prevention Surveillance (CHAMPS) platform aims to investigate causes of dea...
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| Veröffentlicht in: | Clinical infectious diseases 2021-09, Vol.73 (Supplement_3), p.S218-S228 |
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| creator | Blau, Dianna M Baillie, Vicky L Els, Toyah Mahtab, Sana Mutevedzi, Portia Keita, Adama Mamby Kotloff, Karen L Mehta, Ashka Sow, Samba O Tapia, Milagritos D Tippett Barr, Beth A Oluoch, Benard O Onyango, Clayton Revathi, Gunturu Verani, Jennifer R Abayneh, Mahlet Assefa, Nega Madrid, Lola Oundo, Joseph O Scott, J Anthony G Bassat, Quique Mandomando, Inacio Sitoe, Antonio Valente, Marta Varo, Rosauro Bassey, Ima-Abasi Cain, Carrie Jo Jambai, Amara Ogbuanu, Ikechukwu Ojulong, Julius Alam, Muntasir El Arifeen, Shams Gurley, Emily S Rahman, Afruna Rahman, Mustafizur Waller, Jessica L Dewey, Betsy Breiman, Robert F Whitney, Cynthia G Madhi, Shabir A |
| description | Abstract
Background
Lower respiratory tract infections are a leading cause of death in young children, but few studies have collected the specimens needed to define the role of specific causes. The Child Health and Mortality Prevention Surveillance (CHAMPS) platform aims to investigate causes of death in children aged |
| doi_str_mv | 10.1093/cid/ciab509 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8411256</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/cid/ciab509</oup_id><sourcerecordid>2568589344</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-4a07a511bf6342b55ac7275b3bf5e9ab44e975fcb1f5f3ead9bd0db0a0f2a9043</originalsourceid><addsrcrecordid>eNp9kd-K1DAUxoso7rp65QvkSlakmjTNtPFCGMY_I-zisqOCV-GkPZ1GOklN0oHe-Q4-hy_lk5hhBsUbL8IJ-X7nOzl8WfaY0eeMSv6iMW06oAWVd7JzJniVL4Rkd9Odijova16fZQ9C-EopYzUV97MzXpZVIarqPPv5GiH2gSxj9EZPEVsSHbnFMBoP0fmZbGbbzNHAQD4bPwViLPniJrslq94MrUd7eFmbbf_r-49r5yMMJs7kFiKSDcZo7Da8TIZjkkjn3e7YR9YIQ-wJ2Jb87brxuEcbjbNkM_k9mmEA2yC5XK2X1zebpw-zex0MAR-d6kX26e2bj6t1fvXh3fvV8ipveC1jXgKtQDCmuwUvCy0ENFVRCc11J1CCLkuUlegazTrRcYRW6pa2mgLtCpC05BfZq6PvOOkdtk36k4dBjd7swM_KgVH_Ktb0auv2qi4ZK8QiGVyeDLz7NmGIamdCg4d10E1BJaYWtUw5JPTZEW28C8Fj92cMo-oQsEoBq1PAiX5ypN00_hf8Df8zq3E</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2568589344</pqid></control><display><type>article</type><title>Deaths Attributed to Respiratory Syncytial Virus in Young Children in High–Mortality Rate Settings: Report from Child Health and Mortality Prevention Surveillance (CHAMPS)</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Blau, Dianna M ; Baillie, Vicky L ; Els, Toyah ; Mahtab, Sana ; Mutevedzi, Portia ; Keita, Adama Mamby ; Kotloff, Karen L ; Mehta, Ashka ; Sow, Samba O ; Tapia, Milagritos D ; Tippett Barr, Beth A ; Oluoch, Benard O ; Onyango, Clayton ; Revathi, Gunturu ; Verani, Jennifer R ; Abayneh, Mahlet ; Assefa, Nega ; Madrid, Lola ; Oundo, Joseph O ; Scott, J Anthony G ; Bassat, Quique ; Mandomando, Inacio ; Sitoe, Antonio ; Valente, Marta ; Varo, Rosauro ; Bassey, Ima-Abasi ; Cain, Carrie Jo ; Jambai, Amara ; Ogbuanu, Ikechukwu ; Ojulong, Julius ; Alam, Muntasir ; El Arifeen, Shams ; Gurley, Emily S ; Rahman, Afruna ; Rahman, Mustafizur ; Waller, Jessica L ; Dewey, Betsy ; Breiman, Robert F ; Whitney, Cynthia G ; Madhi, Shabir A</creator><creatorcontrib>Blau, Dianna M ; Baillie, Vicky L ; Els, Toyah ; Mahtab, Sana ; Mutevedzi, Portia ; Keita, Adama Mamby ; Kotloff, Karen L ; Mehta, Ashka ; Sow, Samba O ; Tapia, Milagritos D ; Tippett Barr, Beth A ; Oluoch, Benard O ; Onyango, Clayton ; Revathi, Gunturu ; Verani, Jennifer R ; Abayneh, Mahlet ; Assefa, Nega ; Madrid, Lola ; Oundo, Joseph O ; Scott, J Anthony G ; Bassat, Quique ; Mandomando, Inacio ; Sitoe, Antonio ; Valente, Marta ; Varo, Rosauro ; Bassey, Ima-Abasi ; Cain, Carrie Jo ; Jambai, Amara ; Ogbuanu, Ikechukwu ; Ojulong, Julius ; Alam, Muntasir ; El Arifeen, Shams ; Gurley, Emily S ; Rahman, Afruna ; Rahman, Mustafizur ; Waller, Jessica L ; Dewey, Betsy ; Breiman, Robert F ; Whitney, Cynthia G ; Madhi, Shabir A ; CHAMPS Consortium</creatorcontrib><description>Abstract
Background
Lower respiratory tract infections are a leading cause of death in young children, but few studies have collected the specimens needed to define the role of specific causes. The Child Health and Mortality Prevention Surveillance (CHAMPS) platform aims to investigate causes of death in children aged <5 years in high–mortality rate settings, using postmortem minimally invasive tissue sampling and other advanced diagnostic techniques. We examined findings for deaths identified in CHAMPS sites in 7 countries in sub-Saharan Africa and south Asia to evaluate the role of respiratory syncytial virus (RSV).
Methods
We included deaths that occurred between December 2016 and December 2019. Panels determined causes of deaths by reviewing all available data including pathological results from minimally invasive tissue sampling, polymerase chain reaction screening for multiple infectious pathogens in lung tissue, nasopharyngeal swab, blood, and cerebrospinal fluid samples, clinical information from medical records, and verbal autopsies.
Results
We evaluated 1213 deaths, including 695 in neonates (aged <28 days), 283 in infants (28 days to <12 months), and 235 in children (12–59 months). RSV was detected in postmortem specimens in 67 of 1213 deaths (5.5%); in 24 deaths (2.0% of total), RSV was determined to be a cause of death, and it contributed to 5 other deaths. Younger infants (28 days to <6 months of age) accounted for half of all deaths attributed to RSV; 6.5% of all deaths in younger infants were attributed to RSV. RSV was the underlying and only cause in 4 deaths; the remainder (n = 20) had a median of 2 (range, 1–5) other conditions in the causal chain. Birth defects (n = 8) and infections with other pathogens (n = 17) were common comorbid conditions.
Conclusions
RSV is an important cause of child deaths, particularly in young infants. These findings add to the substantial body of literature calling for better treatment and prevention options for RSV in high–mortality rate settings.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciab509</identifier><identifier>PMID: 34472577</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Supplement</subject><ispartof>Clinical infectious diseases, 2021-09, Vol.73 (Supplement_3), p.S218-S228</ispartof><rights>The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-4a07a511bf6342b55ac7275b3bf5e9ab44e975fcb1f5f3ead9bd0db0a0f2a9043</citedby><cites>FETCH-LOGICAL-c389t-4a07a511bf6342b55ac7275b3bf5e9ab44e975fcb1f5f3ead9bd0db0a0f2a9043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Blau, Dianna M</creatorcontrib><creatorcontrib>Baillie, Vicky L</creatorcontrib><creatorcontrib>Els, Toyah</creatorcontrib><creatorcontrib>Mahtab, Sana</creatorcontrib><creatorcontrib>Mutevedzi, Portia</creatorcontrib><creatorcontrib>Keita, Adama Mamby</creatorcontrib><creatorcontrib>Kotloff, Karen L</creatorcontrib><creatorcontrib>Mehta, Ashka</creatorcontrib><creatorcontrib>Sow, Samba O</creatorcontrib><creatorcontrib>Tapia, Milagritos D</creatorcontrib><creatorcontrib>Tippett Barr, Beth A</creatorcontrib><creatorcontrib>Oluoch, Benard O</creatorcontrib><creatorcontrib>Onyango, Clayton</creatorcontrib><creatorcontrib>Revathi, Gunturu</creatorcontrib><creatorcontrib>Verani, Jennifer R</creatorcontrib><creatorcontrib>Abayneh, Mahlet</creatorcontrib><creatorcontrib>Assefa, Nega</creatorcontrib><creatorcontrib>Madrid, Lola</creatorcontrib><creatorcontrib>Oundo, Joseph O</creatorcontrib><creatorcontrib>Scott, J Anthony G</creatorcontrib><creatorcontrib>Bassat, Quique</creatorcontrib><creatorcontrib>Mandomando, Inacio</creatorcontrib><creatorcontrib>Sitoe, Antonio</creatorcontrib><creatorcontrib>Valente, Marta</creatorcontrib><creatorcontrib>Varo, Rosauro</creatorcontrib><creatorcontrib>Bassey, Ima-Abasi</creatorcontrib><creatorcontrib>Cain, Carrie Jo</creatorcontrib><creatorcontrib>Jambai, Amara</creatorcontrib><creatorcontrib>Ogbuanu, Ikechukwu</creatorcontrib><creatorcontrib>Ojulong, Julius</creatorcontrib><creatorcontrib>Alam, Muntasir</creatorcontrib><creatorcontrib>El Arifeen, Shams</creatorcontrib><creatorcontrib>Gurley, Emily S</creatorcontrib><creatorcontrib>Rahman, Afruna</creatorcontrib><creatorcontrib>Rahman, Mustafizur</creatorcontrib><creatorcontrib>Waller, Jessica L</creatorcontrib><creatorcontrib>Dewey, Betsy</creatorcontrib><creatorcontrib>Breiman, Robert F</creatorcontrib><creatorcontrib>Whitney, Cynthia G</creatorcontrib><creatorcontrib>Madhi, Shabir A</creatorcontrib><creatorcontrib>CHAMPS Consortium</creatorcontrib><title>Deaths Attributed to Respiratory Syncytial Virus in Young Children in High–Mortality Rate Settings: Report from Child Health and Mortality Prevention Surveillance (CHAMPS)</title><title>Clinical infectious diseases</title><description>Abstract
Background
Lower respiratory tract infections are a leading cause of death in young children, but few studies have collected the specimens needed to define the role of specific causes. The Child Health and Mortality Prevention Surveillance (CHAMPS) platform aims to investigate causes of death in children aged <5 years in high–mortality rate settings, using postmortem minimally invasive tissue sampling and other advanced diagnostic techniques. We examined findings for deaths identified in CHAMPS sites in 7 countries in sub-Saharan Africa and south Asia to evaluate the role of respiratory syncytial virus (RSV).
Methods
We included deaths that occurred between December 2016 and December 2019. Panels determined causes of deaths by reviewing all available data including pathological results from minimally invasive tissue sampling, polymerase chain reaction screening for multiple infectious pathogens in lung tissue, nasopharyngeal swab, blood, and cerebrospinal fluid samples, clinical information from medical records, and verbal autopsies.
Results
We evaluated 1213 deaths, including 695 in neonates (aged <28 days), 283 in infants (28 days to <12 months), and 235 in children (12–59 months). RSV was detected in postmortem specimens in 67 of 1213 deaths (5.5%); in 24 deaths (2.0% of total), RSV was determined to be a cause of death, and it contributed to 5 other deaths. Younger infants (28 days to <6 months of age) accounted for half of all deaths attributed to RSV; 6.5% of all deaths in younger infants were attributed to RSV. RSV was the underlying and only cause in 4 deaths; the remainder (n = 20) had a median of 2 (range, 1–5) other conditions in the causal chain. Birth defects (n = 8) and infections with other pathogens (n = 17) were common comorbid conditions.
Conclusions
RSV is an important cause of child deaths, particularly in young infants. These findings add to the substantial body of literature calling for better treatment and prevention options for RSV in high–mortality rate settings.</description><subject>Supplement</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kd-K1DAUxoso7rp65QvkSlakmjTNtPFCGMY_I-zisqOCV-GkPZ1GOklN0oHe-Q4-hy_lk5hhBsUbL8IJ-X7nOzl8WfaY0eeMSv6iMW06oAWVd7JzJniVL4Rkd9Odijova16fZQ9C-EopYzUV97MzXpZVIarqPPv5GiH2gSxj9EZPEVsSHbnFMBoP0fmZbGbbzNHAQD4bPwViLPniJrslq94MrUd7eFmbbf_r-49r5yMMJs7kFiKSDcZo7Da8TIZjkkjn3e7YR9YIQ-wJ2Jb87brxuEcbjbNkM_k9mmEA2yC5XK2X1zebpw-zex0MAR-d6kX26e2bj6t1fvXh3fvV8ipveC1jXgKtQDCmuwUvCy0ENFVRCc11J1CCLkuUlegazTrRcYRW6pa2mgLtCpC05BfZq6PvOOkdtk36k4dBjd7swM_KgVH_Ktb0auv2qi4ZK8QiGVyeDLz7NmGIamdCg4d10E1BJaYWtUw5JPTZEW28C8Fj92cMo-oQsEoBq1PAiX5ypN00_hf8Df8zq3E</recordid><startdate>20210902</startdate><enddate>20210902</enddate><creator>Blau, Dianna M</creator><creator>Baillie, Vicky L</creator><creator>Els, Toyah</creator><creator>Mahtab, Sana</creator><creator>Mutevedzi, Portia</creator><creator>Keita, Adama Mamby</creator><creator>Kotloff, Karen L</creator><creator>Mehta, Ashka</creator><creator>Sow, Samba O</creator><creator>Tapia, Milagritos D</creator><creator>Tippett Barr, Beth A</creator><creator>Oluoch, Benard O</creator><creator>Onyango, Clayton</creator><creator>Revathi, Gunturu</creator><creator>Verani, Jennifer R</creator><creator>Abayneh, Mahlet</creator><creator>Assefa, Nega</creator><creator>Madrid, Lola</creator><creator>Oundo, Joseph O</creator><creator>Scott, J Anthony G</creator><creator>Bassat, Quique</creator><creator>Mandomando, Inacio</creator><creator>Sitoe, Antonio</creator><creator>Valente, Marta</creator><creator>Varo, Rosauro</creator><creator>Bassey, Ima-Abasi</creator><creator>Cain, Carrie Jo</creator><creator>Jambai, Amara</creator><creator>Ogbuanu, Ikechukwu</creator><creator>Ojulong, Julius</creator><creator>Alam, Muntasir</creator><creator>El Arifeen, Shams</creator><creator>Gurley, Emily S</creator><creator>Rahman, Afruna</creator><creator>Rahman, Mustafizur</creator><creator>Waller, Jessica L</creator><creator>Dewey, Betsy</creator><creator>Breiman, Robert F</creator><creator>Whitney, Cynthia G</creator><creator>Madhi, Shabir A</creator><general>Oxford University Press</general><scope>TOX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210902</creationdate><title>Deaths Attributed to Respiratory Syncytial Virus in Young Children in High–Mortality Rate Settings: Report from Child Health and Mortality Prevention Surveillance (CHAMPS)</title><author>Blau, Dianna M ; Baillie, Vicky L ; Els, Toyah ; Mahtab, Sana ; Mutevedzi, Portia ; Keita, Adama Mamby ; Kotloff, Karen L ; Mehta, Ashka ; Sow, Samba O ; Tapia, Milagritos D ; Tippett Barr, Beth A ; Oluoch, Benard O ; Onyango, Clayton ; Revathi, Gunturu ; Verani, Jennifer R ; Abayneh, Mahlet ; Assefa, Nega ; Madrid, Lola ; Oundo, Joseph O ; Scott, J Anthony G ; Bassat, Quique ; Mandomando, Inacio ; Sitoe, Antonio ; Valente, Marta ; Varo, Rosauro ; Bassey, Ima-Abasi ; Cain, Carrie Jo ; Jambai, Amara ; Ogbuanu, Ikechukwu ; Ojulong, Julius ; Alam, Muntasir ; El Arifeen, Shams ; Gurley, Emily S ; Rahman, Afruna ; Rahman, Mustafizur ; Waller, Jessica L ; Dewey, Betsy ; Breiman, Robert F ; Whitney, Cynthia G ; Madhi, Shabir A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-4a07a511bf6342b55ac7275b3bf5e9ab44e975fcb1f5f3ead9bd0db0a0f2a9043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Supplement</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blau, Dianna M</creatorcontrib><creatorcontrib>Baillie, Vicky L</creatorcontrib><creatorcontrib>Els, Toyah</creatorcontrib><creatorcontrib>Mahtab, Sana</creatorcontrib><creatorcontrib>Mutevedzi, Portia</creatorcontrib><creatorcontrib>Keita, Adama Mamby</creatorcontrib><creatorcontrib>Kotloff, Karen L</creatorcontrib><creatorcontrib>Mehta, Ashka</creatorcontrib><creatorcontrib>Sow, Samba O</creatorcontrib><creatorcontrib>Tapia, Milagritos D</creatorcontrib><creatorcontrib>Tippett Barr, Beth A</creatorcontrib><creatorcontrib>Oluoch, Benard O</creatorcontrib><creatorcontrib>Onyango, Clayton</creatorcontrib><creatorcontrib>Revathi, Gunturu</creatorcontrib><creatorcontrib>Verani, Jennifer R</creatorcontrib><creatorcontrib>Abayneh, Mahlet</creatorcontrib><creatorcontrib>Assefa, Nega</creatorcontrib><creatorcontrib>Madrid, Lola</creatorcontrib><creatorcontrib>Oundo, Joseph O</creatorcontrib><creatorcontrib>Scott, J Anthony G</creatorcontrib><creatorcontrib>Bassat, Quique</creatorcontrib><creatorcontrib>Mandomando, Inacio</creatorcontrib><creatorcontrib>Sitoe, Antonio</creatorcontrib><creatorcontrib>Valente, Marta</creatorcontrib><creatorcontrib>Varo, Rosauro</creatorcontrib><creatorcontrib>Bassey, Ima-Abasi</creatorcontrib><creatorcontrib>Cain, Carrie Jo</creatorcontrib><creatorcontrib>Jambai, Amara</creatorcontrib><creatorcontrib>Ogbuanu, Ikechukwu</creatorcontrib><creatorcontrib>Ojulong, Julius</creatorcontrib><creatorcontrib>Alam, Muntasir</creatorcontrib><creatorcontrib>El Arifeen, Shams</creatorcontrib><creatorcontrib>Gurley, Emily S</creatorcontrib><creatorcontrib>Rahman, Afruna</creatorcontrib><creatorcontrib>Rahman, Mustafizur</creatorcontrib><creatorcontrib>Waller, Jessica L</creatorcontrib><creatorcontrib>Dewey, Betsy</creatorcontrib><creatorcontrib>Breiman, Robert F</creatorcontrib><creatorcontrib>Whitney, Cynthia G</creatorcontrib><creatorcontrib>Madhi, Shabir A</creatorcontrib><creatorcontrib>CHAMPS Consortium</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blau, Dianna M</au><au>Baillie, Vicky L</au><au>Els, Toyah</au><au>Mahtab, Sana</au><au>Mutevedzi, Portia</au><au>Keita, Adama Mamby</au><au>Kotloff, Karen L</au><au>Mehta, Ashka</au><au>Sow, Samba O</au><au>Tapia, Milagritos D</au><au>Tippett Barr, Beth A</au><au>Oluoch, Benard O</au><au>Onyango, Clayton</au><au>Revathi, Gunturu</au><au>Verani, Jennifer R</au><au>Abayneh, Mahlet</au><au>Assefa, Nega</au><au>Madrid, Lola</au><au>Oundo, Joseph O</au><au>Scott, J Anthony G</au><au>Bassat, Quique</au><au>Mandomando, Inacio</au><au>Sitoe, Antonio</au><au>Valente, Marta</au><au>Varo, Rosauro</au><au>Bassey, Ima-Abasi</au><au>Cain, Carrie Jo</au><au>Jambai, Amara</au><au>Ogbuanu, Ikechukwu</au><au>Ojulong, Julius</au><au>Alam, Muntasir</au><au>El Arifeen, Shams</au><au>Gurley, Emily S</au><au>Rahman, Afruna</au><au>Rahman, Mustafizur</au><au>Waller, Jessica L</au><au>Dewey, Betsy</au><au>Breiman, Robert F</au><au>Whitney, Cynthia G</au><au>Madhi, Shabir A</au><aucorp>CHAMPS Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deaths Attributed to Respiratory Syncytial Virus in Young Children in High–Mortality Rate Settings: Report from Child Health and Mortality Prevention Surveillance (CHAMPS)</atitle><jtitle>Clinical infectious diseases</jtitle><date>2021-09-02</date><risdate>2021</risdate><volume>73</volume><issue>Supplement_3</issue><spage>S218</spage><epage>S228</epage><pages>S218-S228</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Abstract
Background
Lower respiratory tract infections are a leading cause of death in young children, but few studies have collected the specimens needed to define the role of specific causes. The Child Health and Mortality Prevention Surveillance (CHAMPS) platform aims to investigate causes of death in children aged <5 years in high–mortality rate settings, using postmortem minimally invasive tissue sampling and other advanced diagnostic techniques. We examined findings for deaths identified in CHAMPS sites in 7 countries in sub-Saharan Africa and south Asia to evaluate the role of respiratory syncytial virus (RSV).
Methods
We included deaths that occurred between December 2016 and December 2019. Panels determined causes of deaths by reviewing all available data including pathological results from minimally invasive tissue sampling, polymerase chain reaction screening for multiple infectious pathogens in lung tissue, nasopharyngeal swab, blood, and cerebrospinal fluid samples, clinical information from medical records, and verbal autopsies.
Results
We evaluated 1213 deaths, including 695 in neonates (aged <28 days), 283 in infants (28 days to <12 months), and 235 in children (12–59 months). RSV was detected in postmortem specimens in 67 of 1213 deaths (5.5%); in 24 deaths (2.0% of total), RSV was determined to be a cause of death, and it contributed to 5 other deaths. Younger infants (28 days to <6 months of age) accounted for half of all deaths attributed to RSV; 6.5% of all deaths in younger infants were attributed to RSV. RSV was the underlying and only cause in 4 deaths; the remainder (n = 20) had a median of 2 (range, 1–5) other conditions in the causal chain. Birth defects (n = 8) and infections with other pathogens (n = 17) were common comorbid conditions.
Conclusions
RSV is an important cause of child deaths, particularly in young infants. These findings add to the substantial body of literature calling for better treatment and prevention options for RSV in high–mortality rate settings.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>34472577</pmid><doi>10.1093/cid/ciab509</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2021-09, Vol.73 (Supplement_3), p.S218-S228 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8411256 |
| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Supplement |
| title | Deaths Attributed to Respiratory Syncytial Virus in Young Children in High–Mortality Rate Settings: Report from Child Health and Mortality Prevention Surveillance (CHAMPS) |
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