Enhanced expression of P2X4 purinoceptors in pyramidal neurons of the rat hippocampal CA1 region may be involved ischemia-reperfusion injury

Ischemic stroke is the most serious disease that harms human beings. In principle, its treatment is to restore blood flow supply as soon as possible. However, after the blood flow is restored, it will lead to secondary brain injury, that is, ischemia-reperfusion injury. The mechanism of ischemia-rep...

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Veröffentlicht in:	Purinergic signalling 2021-09, Vol.17 (3), p.425-438
Hauptverfasser:	Xiang, Zhenghua, Jiang, Xin, Ji, Rihui, Yuan, Hongbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Benzodiazepinones - pharmacology Biomedical and Life Sciences Biomedicine Blood flow Brain injury Brain Ischemia - genetics Brain Ischemia - metabolism Brain Ischemia - pathology CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - metabolism Cancer Research Gene Expression Hippocampus Human Physiology Ischemia Male Neurodegeneration Neurosciences Original Original Article Pharmacology/Toxicology Purine P2X receptors Purinergic P2X Receptor Antagonists - pharmacology Pyramidal cells Pyramidal Cells - drug effects Pyramidal Cells - metabolism Rats Rats, Sprague-Dawley Receptors, Purinergic P2X4 - biosynthesis Receptors, Purinergic P2X4 - genetics Reperfusion Reperfusion Injury - genetics Reperfusion Injury - metabolism Reperfusion Injury - pathology
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