$Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML$

Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML

Acute myeloid leukemia (AML) with mutated NPM1 accounts for one-third of newly diagnosed AML. Despite recent advances, treatment of relapsed/refractory NPM1 -mutated AML remains challenging, with the majority of patients eventually dying due to disease progression. Moreover, the prognosis is particu...

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Veröffentlicht in:	Leukemia 2021-09, Vol.35 (9), p.2552-2562
Hauptverfasser:	Gionfriddo, Ilaria, Brunetti, Lorenzo, Mezzasoma, Federica, Milano, Francesca, Cardinali, Valeria, Ranieri, Roberta, Venanzi, Alessandra, Pierangeli, Sara, Vetro, Calogero, Spinozzi, Giulio, Dorillo, Erica, Wu, Hsin Chieh, Berthier, Caroline, Ciurnelli, Raffaella, Griffin, Melanie J., Jennings, Claire E., Tiacci, Enrico, Sportoletti, Paolo, Falzetti, Franca, de Thé, Hugues, Veal, Gareth J., Martelli, Maria Paola, Falini, Brunangelo
Format:	Artikel
Sprache:	eng
Schlagworte:	14/1 14/63 42/44 631/67/1059/99 692/308/575 82/80 96/1 Acute myeloid leukemia Cancer Research Clinical trials Critical Care Medicine Dactinomycin Drug dosages Gene mutations Health aspects Health services Hematology Hypotheses Intensive Internal Medicine Leukemia Life Sciences Localization Medicine Medicine & Public Health Myeloid leukemia Nucleoli Oncology Patient outcomes Patients Pharmacokinetics Phosphoproteins Remission Remission (Medicine) RNA polymerase Stress response Tumors
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