The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions

Pulmonary hypertension (PH) is a devastating disease characterized by progressive elevation of pulmonary vascular resistance, right ventricular failure, and ultimately death. We have shown previously that insulin receptor substrate 2 (IRS2), a molecule highly critical to insulin resistance and metab...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2021-08, Vol.321 (2), p.L416-L428
Hauptverfasser:	Nakahara, Mayumi, Ito, Homare, Skinner, John T, Lin, Qing, Tamosiuniene, Rasa, Nicolls, Mark R, Keegan, Achsah D, Johns, Roger A, Yamaji-Kegan, Kazuyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation AKT protein Animal models Animals Arginase Bone marrow Cell activation Congestive heart failure Disease Models, Animal Female Forkhead Box Protein O1 - genetics Forkhead Box Protein O1 - metabolism Forkhead protein FOXO1 protein Gene deletion Gene dosage Growth factors Humans Hypertension Hypertension, Pulmonary - genetics Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - pathology Hypertrophy Hypoxia Hypoxia - genetics Hypoxia - metabolism Hypoxia - pathology Immunomodulation Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Insulin Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - metabolism Insulin resistance IRS-2 gene Lungs Lymphocytes T Macrophages Male Metabolism Mice Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Nude Recruitment Right ventricular failure Signal transduction Signaling Substrates Vascular endothelial growth factor Vascular Remodeling Ventricle
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