T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling

Genome-wide association studies revealed that loss-of-function mutations in protein tyrosine phosphatase non-receptor type 2 (PTPN2) increase the risk of developing chronic immune diseases, such as inflammatory bowel disease (IBD) and celiac disease. These conditions are associated with increased in...

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Veröffentlicht in:	The Journal of clinical investigation 2021-09, Vol.131 (17), p.1-17
Hauptverfasser:	Marchelletta, Ronald R., Krishnan, Moorthy, Spalinger, Marianne R., Placone, Taylaur W., Alvarez, Rocio, Sayoc-Becerra, Anica, Canale, Vinicius, Shawki, Ali, Park, Young Su, Bernts, Lucas H.P., Myers, Stephen, Tremblay, Michel L., Barrett, Kim E., Krystofiak, Evan, Kachar, Bechara, McGovern, Dermot P.B., Weber, Christopher R., Hanson, Elaine M., Eckmann, Lars, McCole, Declan F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Celiac disease Colon Cysteine proteinase Cytokines Electrolytes Epithelial cells Genome-wide association studies Genomes Immunological diseases Inflammation Inflammatory bowel disease Inflammatory bowel diseases Intestine Kinases Localization Lymphocytes Lymphocytes T Mutation Pathogenesis Permeability Phosphatase Phosphorylation Protein-tyrosine-phosphatase Proteins PTPN2 protein Rodents Single-nucleotide polymorphism Small intestine Tight junctions Zonula occludens-1 protein γ-Interferon
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