Mirtronic miR-4646-5p promotes gastric cancer metastasis by regulating ABHD16A and metabolite lysophosphatidylserines

The aberrant classical miRNAs are considered to play significant roles in tumor progression. However, it remains unclear for nonclassical miRNAs, a set of Drosha-independent miRNAs in the process of various biology. Here, we reveal that a nonclassical miR-4646-5p plays a pivotal role in gastric canc...

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Veröffentlicht in:	Cell death and differentiation 2021-09, Vol.28 (9), p.2708-2727
Hauptverfasser:	Yang, Liping, Hou, Yixuan, Du, Yan-e, Li, Qiao, Zhou, Fanlin, Li, Yu, Zeng, Huan, Jin, Ting, Wan, Xueying, Guan, Shengdong, Wang, Rui, Liu, Manran
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/105 13/51 13/89 13/95 14 38 38/61 38/77 42 45 45/15 59 631/45/320 631/67/322 64 82 Animals Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Chromosome 5 Cofilin Gastric cancer Humans Life Sciences Lipid metabolism Lysophospholipids - metabolism Male Metabolism Metabolites Metabolomics - methods Metastases Metastasis Mice Mice, Nude miRNA Monoacylglycerol Lipases - metabolism Neoplasm Metastasis Phosphatidylserine RhoA protein Stem Cells Stomach Neoplasms - genetics Stomach Neoplasms - pathology Transcription Transfection
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