Oxytocin Receptor Activation Rescues Opioid-Induced Respiratory Depression by Systemic Fentanyl in the Rat

Opioid overdose intervention by naloxone, a high affinity receptor antagonist, reverses opioid-induced respiratory depression (OIRD) and analgesia by displacing opioids. Systemic naloxone stimulates release of the hypothalamic neuropeptide oxytocin, which has analgesic properties and participates in...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2021-08, Vol.378 (2), p.96-107
Hauptverfasser:	Brackley, Allison Doyle, Toney, Glenn M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Animals Dose-Response Relationship, Drug Drug Discovery and Translational Medicine Fentanyl - pharmacology Male Oxytocin - metabolism Oxytocin - pharmacology Rats Rats, Sprague-Dawley Receptors, Oxytocin - antagonists & inhibitors Receptors, Oxytocin - metabolism Respiratory Insufficiency - chemically induced Respiratory Insufficiency - drug therapy Respiratory Insufficiency - metabolism Respiratory Insufficiency - prevention & control
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