Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment
Traditional Chinese medicine (TCM) has good clinical application prospects in diabetes treatment. In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Ber...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2021, Vol.2021, p.1-15 |
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| container_title | Evidence-based complementary and alternative medicine |
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| creator | Han, Yunfeng Xiang, Yunan Shi, Yi Tang, Xi Pan, Lin Gao, Jie Bi, Ruohong Lai, Xianrong |
| description | Traditional Chinese medicine (TCM) has good clinical application prospects in diabetes treatment. In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Berberidis Cortex). Furthermore, BBR can reduce blood sugar and blood fat, alleviate inflammation, and improve the state of patients. Based on the recent study results of BBR in diabetes treatment, the BBR pharmacokinetics and mechanism on diabetes are mainly studied, and the specific molecular mechanism of related experimental BBR is systematically summarized and analyzed. Clinical studies have proved that BBR has a good therapeutic effect on diabetes, suggesting that BBR may be a promising drug candidate for diabetes. More detailed BBR mechanisms and pathways of BBR need to be studied further in depth, which will help understand the BBR pharmacology in diabetes treatment. |
| doi_str_mv | 10.1155/2021/9987097 |
| format | Article |
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In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Berberidis Cortex). Furthermore, BBR can reduce blood sugar and blood fat, alleviate inflammation, and improve the state of patients. Based on the recent study results of BBR in diabetes treatment, the BBR pharmacokinetics and mechanism on diabetes are mainly studied, and the specific molecular mechanism of related experimental BBR is systematically summarized and analyzed. Clinical studies have proved that BBR has a good therapeutic effect on diabetes, suggesting that BBR may be a promising drug candidate for diabetes. More detailed BBR mechanisms and pathways of BBR need to be studied further in depth, which will help understand the BBR pharmacology in diabetes treatment.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2021/9987097</identifier><identifier>PMID: 34471420</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Berberine ; Bile ; Bioavailability ; Chinese medicine ; Diabetes ; Diabetes mellitus ; Enzymes ; Experiments ; Feces ; Hydrogenation ; Insulin ; Lipids ; Liver ; Metabolism ; Metabolites ; Microbiota ; Nanoparticles ; Oral administration ; Pharmacokinetics ; Review ; Traditional Chinese medicine ; Urine</subject><ispartof>Evidence-based complementary and alternative medicine, 2021, Vol.2021, p.1-15</ispartof><rights>Copyright © 2021 Yunfeng Han et al.</rights><rights>Copyright © 2021 Yunfeng Han et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Yunfeng Han et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-858dc0bd351f2b95e54dcc60abe6faa395da75f1fdd933f6573bb888eac5db8a3</citedby><cites>FETCH-LOGICAL-c425t-858dc0bd351f2b95e54dcc60abe6faa395da75f1fdd933f6573bb888eac5db8a3</cites><orcidid>0000-0001-8323-8185 ; 0000-0002-1133-1505</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405293/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405293/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids></links><search><contributor>Mediani, Ahmed</contributor><contributor>Ahmed Mediani</contributor><creatorcontrib>Han, Yunfeng</creatorcontrib><creatorcontrib>Xiang, Yunan</creatorcontrib><creatorcontrib>Shi, Yi</creatorcontrib><creatorcontrib>Tang, Xi</creatorcontrib><creatorcontrib>Pan, Lin</creatorcontrib><creatorcontrib>Gao, Jie</creatorcontrib><creatorcontrib>Bi, Ruohong</creatorcontrib><creatorcontrib>Lai, Xianrong</creatorcontrib><title>Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment</title><title>Evidence-based complementary and alternative medicine</title><description>Traditional Chinese medicine (TCM) has good clinical application prospects in diabetes treatment. In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Berberidis Cortex). Furthermore, BBR can reduce blood sugar and blood fat, alleviate inflammation, and improve the state of patients. Based on the recent study results of BBR in diabetes treatment, the BBR pharmacokinetics and mechanism on diabetes are mainly studied, and the specific molecular mechanism of related experimental BBR is systematically summarized and analyzed. Clinical studies have proved that BBR has a good therapeutic effect on diabetes, suggesting that BBR may be a promising drug candidate for diabetes. More detailed BBR mechanisms and pathways of BBR need to be studied further in depth, which will help understand the BBR pharmacology in diabetes treatment.</description><subject>Berberine</subject><subject>Bile</subject><subject>Bioavailability</subject><subject>Chinese medicine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Enzymes</subject><subject>Experiments</subject><subject>Feces</subject><subject>Hydrogenation</subject><subject>Insulin</subject><subject>Lipids</subject><subject>Liver</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Microbiota</subject><subject>Nanoparticles</subject><subject>Oral administration</subject><subject>Pharmacokinetics</subject><subject>Review</subject><subject>Traditional Chinese medicine</subject><subject>Urine</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU9rGzEQxUVoSVwnt3yAhV4K7SaSdmVJl4Cb_knBIT2kEMhBzEpaW87uypW0Cf32lbETaA85zTDvx5sZHkKnBJ8Rwtg5xZScSyk4lvwATQivSVlTId689PzuCL2LcY0xlZzzQ3RU1TUnNcUTdP9zBaEH7R_cYJPTsYDBFM_Dzi-dhq6Y6-QeXXI2Fr4tPtvQ2JD5wg3FFweNTVm4tl3n0hiL22Ah9XZIx-htC120J_s6Rb--fb29vCoXN99_XM4Xpa4pS6VgwmjcmIqRljaSWVYbrWc4-85agEoyA5y1pDVGVlU7Y7xqGiGEBc1MI6Caooud72Zsemt0Xh2gU5vgegh_lAen_lUGt1JL_6hEjRnNnlP0YW8Q_O_RxqR6F3X-Bwbrx6gomwkmOSE8o-__Q9d-DEN-b0tJyiknIlOfdpQOPsZg25djCFbb1NQ2NbVPLeMfd_jKDQae3Ov0X9Ypl-I</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Han, Yunfeng</creator><creator>Xiang, Yunan</creator><creator>Shi, Yi</creator><creator>Tang, Xi</creator><creator>Pan, Lin</creator><creator>Gao, Jie</creator><creator>Bi, Ruohong</creator><creator>Lai, Xianrong</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8323-8185</orcidid><orcidid>https://orcid.org/0000-0002-1133-1505</orcidid></search><sort><creationdate>2021</creationdate><title>Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment</title><author>Han, Yunfeng ; Xiang, Yunan ; Shi, Yi ; Tang, Xi ; Pan, Lin ; Gao, Jie ; Bi, Ruohong ; Lai, Xianrong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-858dc0bd351f2b95e54dcc60abe6faa395da75f1fdd933f6573bb888eac5db8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Berberine</topic><topic>Bile</topic><topic>Bioavailability</topic><topic>Chinese medicine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Enzymes</topic><topic>Experiments</topic><topic>Feces</topic><topic>Hydrogenation</topic><topic>Insulin</topic><topic>Lipids</topic><topic>Liver</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Microbiota</topic><topic>Nanoparticles</topic><topic>Oral administration</topic><topic>Pharmacokinetics</topic><topic>Review</topic><topic>Traditional Chinese medicine</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Yunfeng</creatorcontrib><creatorcontrib>Xiang, Yunan</creatorcontrib><creatorcontrib>Shi, Yi</creatorcontrib><creatorcontrib>Tang, Xi</creatorcontrib><creatorcontrib>Pan, Lin</creatorcontrib><creatorcontrib>Gao, Jie</creatorcontrib><creatorcontrib>Bi, Ruohong</creatorcontrib><creatorcontrib>Lai, Xianrong</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Yunfeng</au><au>Xiang, Yunan</au><au>Shi, Yi</au><au>Tang, Xi</au><au>Pan, Lin</au><au>Gao, Jie</au><au>Bi, Ruohong</au><au>Lai, Xianrong</au><au>Mediani, Ahmed</au><au>Ahmed Mediani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>1</spage><epage>15</epage><pages>1-15</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Traditional Chinese medicine (TCM) has good clinical application prospects in diabetes treatment. In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Berberidis Cortex). Furthermore, BBR can reduce blood sugar and blood fat, alleviate inflammation, and improve the state of patients. Based on the recent study results of BBR in diabetes treatment, the BBR pharmacokinetics and mechanism on diabetes are mainly studied, and the specific molecular mechanism of related experimental BBR is systematically summarized and analyzed. Clinical studies have proved that BBR has a good therapeutic effect on diabetes, suggesting that BBR may be a promising drug candidate for diabetes. More detailed BBR mechanisms and pathways of BBR need to be studied further in depth, which will help understand the BBR pharmacology in diabetes treatment.</abstract><cop>New York</cop><pub>Hindawi</pub><pmid>34471420</pmid><doi>10.1155/2021/9987097</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-8323-8185</orcidid><orcidid>https://orcid.org/0000-0002-1133-1505</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Berberine Bile Bioavailability Chinese medicine Diabetes Diabetes mellitus Enzymes Experiments Feces Hydrogenation Insulin Lipids Liver Metabolism Metabolites Microbiota Nanoparticles Oral administration Pharmacokinetics Review Traditional Chinese medicine Urine |
| title | Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment |
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