Role of iNOS in osteoarthritis: Pathological and therapeutic aspects

Accumulating evidence suggests that inflammation has a key role in the pathogenesis of osteoarthritis (OA). Nitric oxide (NO) has been established as one of the major inflammatory mediators in OA and drives many pathological changes during the development and progression of OA. Excessive production...

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Veröffentlicht in:	Journal of cellular physiology 2020-10, Vol.235 (10), p.6366-6376
Hauptverfasser:	Ahmad, Nashrah, Ansari, Mohammad Y., Haqqi, Tariq M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Arthritis Bioactive compounds Biomedical materials Cartilage Cartilage diseases Chemical synthesis Chondrocytes Clinical trials Humans Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Inflammation Mediators - metabolism Inhibitors iNOS iNOS inhibitor Nitric oxide Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - metabolism Osteoarthritis - pathology Oxidative stress Pathogenesis Plant extracts Plant Extracts - pharmacology
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