Cessation of smoke exposure improves pediatric CF outcomes: Longitudinal analysis of CF Foundation Patient Registry data
•Cessation of smoke exposure reduces the odds of a pulmonary exacerbation by 17% in the first year and by 6% in each additional year of cessation.•Cessation of smoke exposure is associated with 0.7% increase in ppFEV1 in the first year and 0.4% increase in each additional year of cessation.•Cessatio...
Gespeichert in:
| Veröffentlicht in: | Journal of cystic fibrosis 2021-07, Vol.20 (4), p.618-624 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 624 |
|---|---|
| container_issue | 4 |
| container_start_page | 618 |
| container_title | Journal of cystic fibrosis |
| container_volume | 20 |
| creator | Oates, Gabriela R. Baker, Elizabeth Collaco, Joseph M. Rowe, Steven M. Rutland, Sarah B. Fowler, Christopher M. Harris, William T. |
| description | •Cessation of smoke exposure reduces the odds of a pulmonary exacerbation by 17% in the first year and by 6% in each additional year of cessation.•Cessation of smoke exposure is associated with 0.7% increase in ppFEV1 in the first year and 0.4% increase in each additional year of cessation.•Cessation of smoke exposure is associated with 1% increase in BMI percentile in the first year and 0.4% increase in each additional year of cessation.•Eliminating smoke exposure may improve CF respiratory and nutritional outcomes and should be prioritized in CF care.
Tobacco smoke exposure is a major risk factor for the health of children and adolescents with CF. In this study, we assess whether cessation of smoke exposure is associated with improved outcomes in this population.
We used annualized and encounter-based data from the U.S. CF Foundation Patient Registry (2006-2018) on all individuals born 1998-2010. The analytical sample included those who ever reported second-hand smoke exposure (daily or weekly), ever lived with a smoker, or ever reported smoking themselves. We used non-linear mixed models for pulmonary exacerbations and linear mixed models for ppFEV1 and BMI as a function of ceased exposure.
The sample included 3,633 individuals contributing 19,629 person-years. Cessation of smoke exposure reduced the odds of a pulmonary exacerbation in 12 months by 17% (OR 0.83, p |
| doi_str_mv | 10.1016/j.jcf.2021.06.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8403625</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1569199321013011</els_id><sourcerecordid>2553524146</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-1bb9c9165b811606d4a4264b3fbe6da05b255ef14d174290d60173b7a3555c253</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhiMEoqXwA7ggH7kk9cQfSUBCqlYsrbRSKwRny7Eni5ckDnay6v57vGypyoWLxxq_88x43ix7C7QACvJyV-xMV5S0hILKggJ_lp1DXbFcUKDP013IJoemYWfZqxh3lEJFq_pldsZ4WUNN6_PsfoUx6tn5kfiOxMH_RIL3k49LQOKGKfg9RjKhdXoOzpDVmvhlNn7A-IFs_Lh182LdqHui03GILh45SbX2y2hP4LsUcJzJV9y6OIcDSXn9OnvR6T7im4d4kX1ff_62us43t19uVleb3HABcw5t25gGpGhrAEml5ZqXkresa1FaTUVbCoEdcAsVLxtqZfokayvNhBCmFOwi-3TiTks7oDVpkKB7NQU36HBQXjv178vofqit36uaUyb_AN4_AIL_tWCc1eCiwb7XI_olqtSfiZIDl0kKJ6kJPsaA3WMboOromNqp5Jg6OqaoVMmxVPPu6XyPFX8tSoKPJwGmLe0dBhVNWqdJlgQ0s7Le_Qf_G5Q9qL8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2553524146</pqid></control><display><type>article</type><title>Cessation of smoke exposure improves pediatric CF outcomes: Longitudinal analysis of CF Foundation Patient Registry data</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Oates, Gabriela R. ; Baker, Elizabeth ; Collaco, Joseph M. ; Rowe, Steven M. ; Rutland, Sarah B. ; Fowler, Christopher M. ; Harris, William T.</creator><creatorcontrib>Oates, Gabriela R. ; Baker, Elizabeth ; Collaco, Joseph M. ; Rowe, Steven M. ; Rutland, Sarah B. ; Fowler, Christopher M. ; Harris, William T.</creatorcontrib><description>•Cessation of smoke exposure reduces the odds of a pulmonary exacerbation by 17% in the first year and by 6% in each additional year of cessation.•Cessation of smoke exposure is associated with 0.7% increase in ppFEV1 in the first year and 0.4% increase in each additional year of cessation.•Cessation of smoke exposure is associated with 1% increase in BMI percentile in the first year and 0.4% increase in each additional year of cessation.•Eliminating smoke exposure may improve CF respiratory and nutritional outcomes and should be prioritized in CF care.
Tobacco smoke exposure is a major risk factor for the health of children and adolescents with CF. In this study, we assess whether cessation of smoke exposure is associated with improved outcomes in this population.
We used annualized and encounter-based data from the U.S. CF Foundation Patient Registry (2006-2018) on all individuals born 1998-2010. The analytical sample included those who ever reported second-hand smoke exposure (daily or weekly), ever lived with a smoker, or ever reported smoking themselves. We used non-linear mixed models for pulmonary exacerbations and linear mixed models for ppFEV1 and BMI as a function of ceased exposure.
The sample included 3,633 individuals contributing 19,629 person-years. Cessation of smoke exposure reduced the odds of a pulmonary exacerbation in 12 months by 17% (OR 0.83, p < 0.001) in the first year of cessation, with an additional 6% decrease (OR 0.94, p = 0.003) for each additional year of cessation. Cessation was associated with improvements in ppFEV1 and BMI: 0.7% ppFEV1 increase (p < 0.001) in the first year of cessation and 0.4% increase (p = 0.001) for each additional year of cessation; 1% increase in BMI percentile (p < 0.001) in the first year of cessation plus 0.4% increase (p = 0.009) for each additional year. Three years of cessation reduce the predicted probability of a pulmonary exacerbation in 12 months by 8% and improve ppFEV1 and BMI by 2%.
Eliminating smoke exposure may reduce pulmonary exacerbations and improve respiratory and nutritional outcomes in children and adolescents with CF. Both smoking cessation and exposure prevention should be prioritized in pediatric CF care.</description><identifier>ISSN: 1569-1993</identifier><identifier>EISSN: 1873-5010</identifier><identifier>DOI: 10.1016/j.jcf.2021.06.014</identifier><identifier>PMID: 34281808</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Child ; Child, Preschool ; Cystic Fibrosis - prevention & control ; Disease Progression ; Female ; Humans ; Male ; Registries ; Secondhand smoke ; Smoke exposure ; Smoking cessation ; Tobacco ; Tobacco Smoke Pollution - prevention & control ; Treatment Outcome ; United States</subject><ispartof>Journal of cystic fibrosis, 2021-07, Vol.20 (4), p.618-624</ispartof><rights>2021 European Cystic Fibrosis Society</rights><rights>Copyright © 2021 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-1bb9c9165b811606d4a4264b3fbe6da05b255ef14d174290d60173b7a3555c253</citedby><cites>FETCH-LOGICAL-c451t-1bb9c9165b811606d4a4264b3fbe6da05b255ef14d174290d60173b7a3555c253</cites><orcidid>0000-0003-4052-1524 ; 0000-0002-2543-8995 ; 0000-0001-9045-0133 ; 0000-0002-1580-0946</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcf.2021.06.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34281808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oates, Gabriela R.</creatorcontrib><creatorcontrib>Baker, Elizabeth</creatorcontrib><creatorcontrib>Collaco, Joseph M.</creatorcontrib><creatorcontrib>Rowe, Steven M.</creatorcontrib><creatorcontrib>Rutland, Sarah B.</creatorcontrib><creatorcontrib>Fowler, Christopher M.</creatorcontrib><creatorcontrib>Harris, William T.</creatorcontrib><title>Cessation of smoke exposure improves pediatric CF outcomes: Longitudinal analysis of CF Foundation Patient Registry data</title><title>Journal of cystic fibrosis</title><addtitle>J Cyst Fibros</addtitle><description>•Cessation of smoke exposure reduces the odds of a pulmonary exacerbation by 17% in the first year and by 6% in each additional year of cessation.•Cessation of smoke exposure is associated with 0.7% increase in ppFEV1 in the first year and 0.4% increase in each additional year of cessation.•Cessation of smoke exposure is associated with 1% increase in BMI percentile in the first year and 0.4% increase in each additional year of cessation.•Eliminating smoke exposure may improve CF respiratory and nutritional outcomes and should be prioritized in CF care.
Tobacco smoke exposure is a major risk factor for the health of children and adolescents with CF. In this study, we assess whether cessation of smoke exposure is associated with improved outcomes in this population.
We used annualized and encounter-based data from the U.S. CF Foundation Patient Registry (2006-2018) on all individuals born 1998-2010. The analytical sample included those who ever reported second-hand smoke exposure (daily or weekly), ever lived with a smoker, or ever reported smoking themselves. We used non-linear mixed models for pulmonary exacerbations and linear mixed models for ppFEV1 and BMI as a function of ceased exposure.
The sample included 3,633 individuals contributing 19,629 person-years. Cessation of smoke exposure reduced the odds of a pulmonary exacerbation in 12 months by 17% (OR 0.83, p < 0.001) in the first year of cessation, with an additional 6% decrease (OR 0.94, p = 0.003) for each additional year of cessation. Cessation was associated with improvements in ppFEV1 and BMI: 0.7% ppFEV1 increase (p < 0.001) in the first year of cessation and 0.4% increase (p = 0.001) for each additional year of cessation; 1% increase in BMI percentile (p < 0.001) in the first year of cessation plus 0.4% increase (p = 0.009) for each additional year. Three years of cessation reduce the predicted probability of a pulmonary exacerbation in 12 months by 8% and improve ppFEV1 and BMI by 2%.
Eliminating smoke exposure may reduce pulmonary exacerbations and improve respiratory and nutritional outcomes in children and adolescents with CF. Both smoking cessation and exposure prevention should be prioritized in pediatric CF care.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cystic Fibrosis - prevention & control</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Registries</subject><subject>Secondhand smoke</subject><subject>Smoke exposure</subject><subject>Smoking cessation</subject><subject>Tobacco</subject><subject>Tobacco Smoke Pollution - prevention & control</subject><subject>Treatment Outcome</subject><subject>United States</subject><issn>1569-1993</issn><issn>1873-5010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhiMEoqXwA7ggH7kk9cQfSUBCqlYsrbRSKwRny7Eni5ckDnay6v57vGypyoWLxxq_88x43ix7C7QACvJyV-xMV5S0hILKggJ_lp1DXbFcUKDP013IJoemYWfZqxh3lEJFq_pldsZ4WUNN6_PsfoUx6tn5kfiOxMH_RIL3k49LQOKGKfg9RjKhdXoOzpDVmvhlNn7A-IFs_Lh182LdqHui03GILh45SbX2y2hP4LsUcJzJV9y6OIcDSXn9OnvR6T7im4d4kX1ff_62us43t19uVleb3HABcw5t25gGpGhrAEml5ZqXkresa1FaTUVbCoEdcAsVLxtqZfokayvNhBCmFOwi-3TiTks7oDVpkKB7NQU36HBQXjv178vofqit36uaUyb_AN4_AIL_tWCc1eCiwb7XI_olqtSfiZIDl0kKJ6kJPsaA3WMboOromNqp5Jg6OqaoVMmxVPPu6XyPFX8tSoKPJwGmLe0dBhVNWqdJlgQ0s7Le_Qf_G5Q9qL8</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Oates, Gabriela R.</creator><creator>Baker, Elizabeth</creator><creator>Collaco, Joseph M.</creator><creator>Rowe, Steven M.</creator><creator>Rutland, Sarah B.</creator><creator>Fowler, Christopher M.</creator><creator>Harris, William T.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4052-1524</orcidid><orcidid>https://orcid.org/0000-0002-2543-8995</orcidid><orcidid>https://orcid.org/0000-0001-9045-0133</orcidid><orcidid>https://orcid.org/0000-0002-1580-0946</orcidid></search><sort><creationdate>202107</creationdate><title>Cessation of smoke exposure improves pediatric CF outcomes: Longitudinal analysis of CF Foundation Patient Registry data</title><author>Oates, Gabriela R. ; Baker, Elizabeth ; Collaco, Joseph M. ; Rowe, Steven M. ; Rutland, Sarah B. ; Fowler, Christopher M. ; Harris, William T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-1bb9c9165b811606d4a4264b3fbe6da05b255ef14d174290d60173b7a3555c253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cystic Fibrosis - prevention & control</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Registries</topic><topic>Secondhand smoke</topic><topic>Smoke exposure</topic><topic>Smoking cessation</topic><topic>Tobacco</topic><topic>Tobacco Smoke Pollution - prevention & control</topic><topic>Treatment Outcome</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oates, Gabriela R.</creatorcontrib><creatorcontrib>Baker, Elizabeth</creatorcontrib><creatorcontrib>Collaco, Joseph M.</creatorcontrib><creatorcontrib>Rowe, Steven M.</creatorcontrib><creatorcontrib>Rutland, Sarah B.</creatorcontrib><creatorcontrib>Fowler, Christopher M.</creatorcontrib><creatorcontrib>Harris, William T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cystic fibrosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oates, Gabriela R.</au><au>Baker, Elizabeth</au><au>Collaco, Joseph M.</au><au>Rowe, Steven M.</au><au>Rutland, Sarah B.</au><au>Fowler, Christopher M.</au><au>Harris, William T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cessation of smoke exposure improves pediatric CF outcomes: Longitudinal analysis of CF Foundation Patient Registry data</atitle><jtitle>Journal of cystic fibrosis</jtitle><addtitle>J Cyst Fibros</addtitle><date>2021-07</date><risdate>2021</risdate><volume>20</volume><issue>4</issue><spage>618</spage><epage>624</epage><pages>618-624</pages><issn>1569-1993</issn><eissn>1873-5010</eissn><abstract>•Cessation of smoke exposure reduces the odds of a pulmonary exacerbation by 17% in the first year and by 6% in each additional year of cessation.•Cessation of smoke exposure is associated with 0.7% increase in ppFEV1 in the first year and 0.4% increase in each additional year of cessation.•Cessation of smoke exposure is associated with 1% increase in BMI percentile in the first year and 0.4% increase in each additional year of cessation.•Eliminating smoke exposure may improve CF respiratory and nutritional outcomes and should be prioritized in CF care.
Tobacco smoke exposure is a major risk factor for the health of children and adolescents with CF. In this study, we assess whether cessation of smoke exposure is associated with improved outcomes in this population.
We used annualized and encounter-based data from the U.S. CF Foundation Patient Registry (2006-2018) on all individuals born 1998-2010. The analytical sample included those who ever reported second-hand smoke exposure (daily or weekly), ever lived with a smoker, or ever reported smoking themselves. We used non-linear mixed models for pulmonary exacerbations and linear mixed models for ppFEV1 and BMI as a function of ceased exposure.
The sample included 3,633 individuals contributing 19,629 person-years. Cessation of smoke exposure reduced the odds of a pulmonary exacerbation in 12 months by 17% (OR 0.83, p < 0.001) in the first year of cessation, with an additional 6% decrease (OR 0.94, p = 0.003) for each additional year of cessation. Cessation was associated with improvements in ppFEV1 and BMI: 0.7% ppFEV1 increase (p < 0.001) in the first year of cessation and 0.4% increase (p = 0.001) for each additional year of cessation; 1% increase in BMI percentile (p < 0.001) in the first year of cessation plus 0.4% increase (p = 0.009) for each additional year. Three years of cessation reduce the predicted probability of a pulmonary exacerbation in 12 months by 8% and improve ppFEV1 and BMI by 2%.
Eliminating smoke exposure may reduce pulmonary exacerbations and improve respiratory and nutritional outcomes in children and adolescents with CF. Both smoking cessation and exposure prevention should be prioritized in pediatric CF care.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>34281808</pmid><doi>10.1016/j.jcf.2021.06.014</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4052-1524</orcidid><orcidid>https://orcid.org/0000-0002-2543-8995</orcidid><orcidid>https://orcid.org/0000-0001-9045-0133</orcidid><orcidid>https://orcid.org/0000-0002-1580-0946</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1569-1993 |
| ispartof | Journal of cystic fibrosis, 2021-07, Vol.20 (4), p.618-624 |
| issn | 1569-1993 1873-5010 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8403625 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Child Child, Preschool Cystic Fibrosis - prevention & control Disease Progression Female Humans Male Registries Secondhand smoke Smoke exposure Smoking cessation Tobacco Tobacco Smoke Pollution - prevention & control Treatment Outcome United States |
| title | Cessation of smoke exposure improves pediatric CF outcomes: Longitudinal analysis of CF Foundation Patient Registry data |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T14%3A07%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cessation%20of%20smoke%20exposure%20improves%20pediatric%20CF%20outcomes:%20Longitudinal%20analysis%20of%20CF%20Foundation%20Patient%20Registry%20data&rft.jtitle=Journal%20of%20cystic%20fibrosis&rft.au=Oates,%20Gabriela%20R.&rft.date=2021-07&rft.volume=20&rft.issue=4&rft.spage=618&rft.epage=624&rft.pages=618-624&rft.issn=1569-1993&rft.eissn=1873-5010&rft_id=info:doi/10.1016/j.jcf.2021.06.014&rft_dat=%3Cproquest_pubme%3E2553524146%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2553524146&rft_id=info:pmid/34281808&rft_els_id=S1569199321013011&rfr_iscdi=true |