Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties
Background: Propyl propane thiosulfonate (PTSO) is an organosulfur compound from Allium spp. that has shown interesting antimicrobial properties and immunomodulatory effects in different experimental models. In this sense, our aim was to evaluate its effect on an experimental model of obesity, focus...
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| Veröffentlicht in: | Nutrients 2021-07, Vol.13 (8), p.2595 |
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| creator | Vezza, Teresa Garrido-Mesa, José Diez-Echave, Patricia Hidalgo-García, Laura Ruiz-Malagón, Antonio J. García, Federico Sánchez, Manuel Toral, Marta Romero, Miguel Duarte, Juan Guillamón, Enrique Baños Arjona, Alberto Moron, Rocío Galvez, Julio Rodríguez-Nogales, Alba Rodríguez-Cabezas, María Elena |
| description | Background: Propyl propane thiosulfonate (PTSO) is an organosulfur compound from Allium spp. that has shown interesting antimicrobial properties and immunomodulatory effects in different experimental models. In this sense, our aim was to evaluate its effect on an experimental model of obesity, focusing on inflammatory and metabolic markers and the gut microbiota. Methods and results: Mice were fed a high-fat diet and orally treated with different doses of PTSO (0.1, 0.5 and 1 mg/kg/day) for 5 weeks. PTSO lessened the weight gain and improved the plasma markers associated with glucose and lipid metabolisms. PTSO also attenuated obesity-associated systemic inflammation, reducing the immune cell infiltration and, thus, the expression of pro-inflammatory cytokines in adipose and hepatic tissues (Il-1ẞ, Il-6, Tnf-α, Mcp-1, Jnk-1, Jnk-2, Leptin, Leptin R, Adiponectin, Ampk, Ppar-α, Ppar-γ, Glut-4 and Tlr-4) and improving the expression of different key elements for gut barrier integrity (Muc-2, Muc-3, Occludin, Zo-1 and Tff-3). Additionally, these effects were connected to a regulation of the gut microbiome, which was altered by the high-fat diet. Conclusion: Allium-derived PTSO can be considered a potential new tool for the treatment of metabolic syndrome. |
| doi_str_mv | 10.3390/nu13082595 |
| format | Article |
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In this sense, our aim was to evaluate its effect on an experimental model of obesity, focusing on inflammatory and metabolic markers and the gut microbiota. Methods and results: Mice were fed a high-fat diet and orally treated with different doses of PTSO (0.1, 0.5 and 1 mg/kg/day) for 5 weeks. PTSO lessened the weight gain and improved the plasma markers associated with glucose and lipid metabolisms. PTSO also attenuated obesity-associated systemic inflammation, reducing the immune cell infiltration and, thus, the expression of pro-inflammatory cytokines in adipose and hepatic tissues (Il-1ẞ, Il-6, Tnf-α, Mcp-1, Jnk-1, Jnk-2, Leptin, Leptin R, Adiponectin, Ampk, Ppar-α, Ppar-γ, Glut-4 and Tlr-4) and improving the expression of different key elements for gut barrier integrity (Muc-2, Muc-3, Occludin, Zo-1 and Tff-3). Additionally, these effects were connected to a regulation of the gut microbiome, which was altered by the high-fat diet. Conclusion: Allium-derived PTSO can be considered a potential new tool for the treatment of metabolic syndrome.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu13082595</identifier><identifier>PMID: 34444755</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Adipocytes ; Adiponectin ; Allium ; Antiinfectives and antibacterials ; Atherosclerosis ; Body weight gain ; Cholesterol ; Diet ; Dietary minerals ; Garlic ; Gene expression ; Genetic testing ; Glucose ; High fat diet ; Humidity ; Hypertension ; Immune system ; Immunomodulation ; Inflammation ; Inflammatory bowel disease ; Insulin ; Interleukin 6 ; Intestinal microflora ; Kinases ; Laboratory animals ; Leptin ; Lipids ; Low density lipoprotein ; Markers ; Metabolic disorders ; Metabolic syndrome ; Microbiomes ; Microbiota ; Mitochondrial DNA ; Monocyte chemoattractant protein 1 ; Obesity ; Organosulfur compounds ; Peroxisome proliferator-activated receptors ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Variance analysis ; Zonula occludens-1 protein</subject><ispartof>Nutrients, 2021-07, Vol.13 (8), p.2595</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-ca92617dd15cb05c307d32ef5dcf7c1695958735a31fe0b29bb966bb09e05a7e3</citedby><cites>FETCH-LOGICAL-c383t-ca92617dd15cb05c307d32ef5dcf7c1695958735a31fe0b29bb966bb09e05a7e3</cites><orcidid>0000-0001-6420-9055 ; 0000-0001-6876-3782 ; 0000-0001-9085-8147 ; 0000-0001-7611-781X ; 0000-0003-1927-0628 ; 0000-0002-9153-5857 ; 0000-0003-4323-650X ; 0000-0002-9780-0180 ; 0000-0002-1691-2587 ; 0000-0003-0578-1099</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400710/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400710/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Vezza, Teresa</creatorcontrib><creatorcontrib>Garrido-Mesa, José</creatorcontrib><creatorcontrib>Diez-Echave, Patricia</creatorcontrib><creatorcontrib>Hidalgo-García, Laura</creatorcontrib><creatorcontrib>Ruiz-Malagón, Antonio J.</creatorcontrib><creatorcontrib>García, Federico</creatorcontrib><creatorcontrib>Sánchez, Manuel</creatorcontrib><creatorcontrib>Toral, Marta</creatorcontrib><creatorcontrib>Romero, Miguel</creatorcontrib><creatorcontrib>Duarte, Juan</creatorcontrib><creatorcontrib>Guillamón, Enrique</creatorcontrib><creatorcontrib>Baños Arjona, Alberto</creatorcontrib><creatorcontrib>Moron, Rocío</creatorcontrib><creatorcontrib>Galvez, Julio</creatorcontrib><creatorcontrib>Rodríguez-Nogales, Alba</creatorcontrib><creatorcontrib>Rodríguez-Cabezas, María Elena</creatorcontrib><title>Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties</title><title>Nutrients</title><description>Background: Propyl propane thiosulfonate (PTSO) is an organosulfur compound from Allium spp. that has shown interesting antimicrobial properties and immunomodulatory effects in different experimental models. In this sense, our aim was to evaluate its effect on an experimental model of obesity, focusing on inflammatory and metabolic markers and the gut microbiota. Methods and results: Mice were fed a high-fat diet and orally treated with different doses of PTSO (0.1, 0.5 and 1 mg/kg/day) for 5 weeks. PTSO lessened the weight gain and improved the plasma markers associated with glucose and lipid metabolisms. PTSO also attenuated obesity-associated systemic inflammation, reducing the immune cell infiltration and, thus, the expression of pro-inflammatory cytokines in adipose and hepatic tissues (Il-1ẞ, Il-6, Tnf-α, Mcp-1, Jnk-1, Jnk-2, Leptin, Leptin R, Adiponectin, Ampk, Ppar-α, Ppar-γ, Glut-4 and Tlr-4) and improving the expression of different key elements for gut barrier integrity (Muc-2, Muc-3, Occludin, Zo-1 and Tff-3). Additionally, these effects were connected to a regulation of the gut microbiome, which was altered by the high-fat diet. Conclusion: Allium-derived PTSO can be considered a potential new tool for the treatment of metabolic syndrome.</description><subject>Adipocytes</subject><subject>Adiponectin</subject><subject>Allium</subject><subject>Antiinfectives and antibacterials</subject><subject>Atherosclerosis</subject><subject>Body weight gain</subject><subject>Cholesterol</subject><subject>Diet</subject><subject>Dietary minerals</subject><subject>Garlic</subject><subject>Gene expression</subject><subject>Genetic testing</subject><subject>Glucose</subject><subject>High fat diet</subject><subject>Humidity</subject><subject>Hypertension</subject><subject>Immune system</subject><subject>Immunomodulation</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Insulin</subject><subject>Interleukin 6</subject><subject>Intestinal microflora</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Leptin</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Markers</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Mitochondrial DNA</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Obesity</subject><subject>Organosulfur compounds</subject><subject>Peroxisome proliferator-activated receptors</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Variance analysis</subject><subject>Zonula occludens-1 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Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties</title><author>Vezza, Teresa ; Garrido-Mesa, José ; Diez-Echave, Patricia ; Hidalgo-García, Laura ; Ruiz-Malagón, Antonio J. ; García, Federico ; Sánchez, Manuel ; Toral, Marta ; Romero, Miguel ; Duarte, Juan ; Guillamón, Enrique ; Baños Arjona, Alberto ; Moron, Rocío ; Galvez, Julio ; Rodríguez-Nogales, Alba ; Rodríguez-Cabezas, María Elena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-ca92617dd15cb05c307d32ef5dcf7c1695958735a31fe0b29bb966bb09e05a7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipocytes</topic><topic>Adiponectin</topic><topic>Allium</topic><topic>Antiinfectives and antibacterials</topic><topic>Atherosclerosis</topic><topic>Body weight gain</topic><topic>Cholesterol</topic><topic>Diet</topic><topic>Dietary minerals</topic><topic>Garlic</topic><topic>Gene expression</topic><topic>Genetic testing</topic><topic>Glucose</topic><topic>High fat diet</topic><topic>Humidity</topic><topic>Hypertension</topic><topic>Immune system</topic><topic>Immunomodulation</topic><topic>Inflammation</topic><topic>Inflammatory bowel disease</topic><topic>Insulin</topic><topic>Interleukin 6</topic><topic>Intestinal microflora</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Leptin</topic><topic>Lipids</topic><topic>Low density lipoprotein</topic><topic>Markers</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Mitochondrial DNA</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Obesity</topic><topic>Organosulfur compounds</topic><topic>Peroxisome proliferator-activated receptors</topic><topic>Tumor necrosis 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Alberto</au><au>Moron, Rocío</au><au>Galvez, Julio</au><au>Rodríguez-Nogales, Alba</au><au>Rodríguez-Cabezas, María Elena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties</atitle><jtitle>Nutrients</jtitle><date>2021-07-28</date><risdate>2021</risdate><volume>13</volume><issue>8</issue><spage>2595</spage><pages>2595-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Background: Propyl propane thiosulfonate (PTSO) is an organosulfur compound from Allium spp. that has shown interesting antimicrobial properties and immunomodulatory effects in different experimental models. In this sense, our aim was to evaluate its effect on an experimental model of obesity, focusing on inflammatory and metabolic markers and the gut microbiota. Methods and results: Mice were fed a high-fat diet and orally treated with different doses of PTSO (0.1, 0.5 and 1 mg/kg/day) for 5 weeks. PTSO lessened the weight gain and improved the plasma markers associated with glucose and lipid metabolisms. PTSO also attenuated obesity-associated systemic inflammation, reducing the immune cell infiltration and, thus, the expression of pro-inflammatory cytokines in adipose and hepatic tissues (Il-1ẞ, Il-6, Tnf-α, Mcp-1, Jnk-1, Jnk-2, Leptin, Leptin R, Adiponectin, Ampk, Ppar-α, Ppar-γ, Glut-4 and Tlr-4) and improving the expression of different key elements for gut barrier integrity (Muc-2, Muc-3, Occludin, Zo-1 and Tff-3). Additionally, these effects were connected to a regulation of the gut microbiome, which was altered by the high-fat diet. Conclusion: Allium-derived PTSO can be considered a potential new tool for the treatment of metabolic syndrome.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34444755</pmid><doi>10.3390/nu13082595</doi><orcidid>https://orcid.org/0000-0001-6420-9055</orcidid><orcidid>https://orcid.org/0000-0001-6876-3782</orcidid><orcidid>https://orcid.org/0000-0001-9085-8147</orcidid><orcidid>https://orcid.org/0000-0001-7611-781X</orcidid><orcidid>https://orcid.org/0000-0003-1927-0628</orcidid><orcidid>https://orcid.org/0000-0002-9153-5857</orcidid><orcidid>https://orcid.org/0000-0003-4323-650X</orcidid><orcidid>https://orcid.org/0000-0002-9780-0180</orcidid><orcidid>https://orcid.org/0000-0002-1691-2587</orcidid><orcidid>https://orcid.org/0000-0003-0578-1099</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2021-07, Vol.13 (8), p.2595 |
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| subjects | Adipocytes Adiponectin Allium Antiinfectives and antibacterials Atherosclerosis Body weight gain Cholesterol Diet Dietary minerals Garlic Gene expression Genetic testing Glucose High fat diet Humidity Hypertension Immune system Immunomodulation Inflammation Inflammatory bowel disease Insulin Interleukin 6 Intestinal microflora Kinases Laboratory animals Leptin Lipids Low density lipoprotein Markers Metabolic disorders Metabolic syndrome Microbiomes Microbiota Mitochondrial DNA Monocyte chemoattractant protein 1 Obesity Organosulfur compounds Peroxisome proliferator-activated receptors Tumor necrosis factor-TNF Tumor necrosis factor-α Variance analysis Zonula occludens-1 protein |
| title | Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T17%3A14%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Allium-Derived%20Compound%20Propyl%20Propane%20Thiosulfonate%20(PTSO)%20Attenuates%20Metabolic%20Alterations%20in%20Mice%20Fed%20a%20High-Fat%20Diet%20through%20Its%20Anti-Inflammatory%20and%20Prebiotic%20Properties&rft.jtitle=Nutrients&rft.au=Vezza,%20Teresa&rft.date=2021-07-28&rft.volume=13&rft.issue=8&rft.spage=2595&rft.pages=2595-&rft.issn=2072-6643&rft.eissn=2072-6643&rft_id=info:doi/10.3390/nu13082595&rft_dat=%3Cproquest_pubme%3E2565482224%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2565482224&rft_id=info:pmid/34444755&rfr_iscdi=true |