A Bidirectional Permeability Assay for beyond Rule of 5 Compounds

Bidirectional permeability measurement with cellular models grown on Transwell inserts is widely used in pharmaceutical research since it not only provides information about the passive permeability of a drug, but also about transport proteins involved in the active transport of drug substances acro...

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Veröffentlicht in:	Pharmaceutics 2021-07, Vol.13 (8), p.1146, Article 1146
Hauptverfasser:	Cui, Yunhai, Desevaux, Cyril, Truebenbach, Ines, Sieger, Peter, Klinder, Klaus, Long, Alan, Sauer, Achim
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Brain research Drug dosages drug transporter efflux Equilibrium Life Sciences & Biomedicine Lipinski’s Rule of 5 oral bioavailability Permeability Pharmaceutical industry Pharmacology & Pharmacy physiological barrier Physiology Plasma Polyvinyl alcohol Proteins R&D Research & development Retention Science & Technology
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