Probiotics Prevent Hypertension in a Murine Model of Systemic Lupus Erythematosus Induced by Toll-Like Receptor 7 Activation
Our group tested the effects of Lactobacillus fermentum CECT5716 (LC40) and/or Bifidobacterium breve CECT7263 (BFM) in the prevention of gut dysbiosis, hypertension and endothelial dysfunction in a pharmacologically-induced model of systemic lupus erythematosus (SLE). We treated eight-week-old BALB/...
Gespeichert in:
| Veröffentlicht in: | Nutrients 2021-07, Vol.13 (8), p.2669 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | 2669 |
| container_title | Nutrients |
| container_volume | 13 |
| creator | de la Visitación, Néstor Robles-Vera, Iñaki Moleón-Moya, Javier Sánchez, Manuel Jiménez, Rosario Gómez-Guzmán, Manuel González-Correa, Cristina Olivares, Mónica Toral, Marta Romero, Miguel Duarte, Juan |
| description | Our group tested the effects of Lactobacillus fermentum CECT5716 (LC40) and/or Bifidobacterium breve CECT7263 (BFM) in the prevention of gut dysbiosis, hypertension and endothelial dysfunction in a pharmacologically-induced model of systemic lupus erythematosus (SLE). We treated eight-week-old BALB/cByJRj mice without (Ctrl) or with the agonist of TLR-7 Imiquimod (IMQ) for 8 weeks. Concomitantly, LC40 (109 CFU/mL) and BFM (109 CFU/mL) were administered through oral gavage once a day. IMQ induced intestinal dysbiosis consisting of a decrease in the α-diversity measured with Chao-richness and numbers of species. LC40 and BFM did not restore these parameters. The three-dimensional principal component analysis of bacterial taxa in stool samples presented perfect clustering between Ctrl and IMQ groups. Clusters corresponding to LC40 and BFM were more akin to IMQ. BFM and LC40 were detected colonizing the gut microbiota of mice treated respectively. LC40 and BFM decreased plasma double-stranded DNA autoantibodies, and B cells in spleen, which were increased in the IMQ group. Also, LC40 and BFM treatments activated TLR9, reduced T cells activation, and Th17 polarization in mesenteric lymph nodes. Aortae from IMQ mice displayed a decreased endothelium-dependent vasodilator response to acetylcholine linked to pro-inflammatory and pro-oxidative status, which were normalized by both BFM and LC40. In conclusion, we demonstrate for the first time that the chronic treatment with LC40 or BFM prevented hypertension and endothelial dysfunction in a mouse lupus model induced by TLR-7 activation. |
| doi_str_mv | 10.3390/nu13082669 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8399640</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A765645036</galeid><sourcerecordid>A765645036</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-71da2c235f14a8d7cc0e1a71108caa63c0ad96f09b23f57e79ea89d8bdad1e543</originalsourceid><addsrcrecordid>eNptkl9L3jAUxsvYUHHe-AkCuxmDuvxpk_Zm8CI6hVeUzV2HNDnVuDbpkvSFwj78UpRNZScXOUl-5wnP4RTFMcEnjLX4s5sJww3lvH1THFAsaMl5xd4-y_eLoxgf8BoCC872in1W5Whoe1D8vgm-sz5ZHdFNgB24hC6WCUICF613yDqk0NUcrAN05Q0MyPfo-xITjFaj7TzNEZ2FJd3DqJKP-XTpzKzBoG5Bt34Yyq39CegbaJiSD0igjU52p1IWf1-869UQ4ehpPyx-nJ_dnl6U2-uvl6ebbamrGqdSEKOopqzuSaUaI7TGQJQgBDdaKc40VqblPW47yvpagGhBNa1pOqMMgbpih8WXR91p7kYwOpsMapBTsKMKi_TKypcvzt7LO7-TDWtbXuEs8PFJIPhfM8QkRxs1DINy4Ocoac05ZpQQkdEPr9AHPweX7a1UnbtOxTPqTg0gret9_levonIjeM2zb8YzdfIfKi-zNt876G2-f1Hw6bFABx9jgP6vR4LlOi7y37iwP-qRsTg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2565482277</pqid></control><display><type>article</type><title>Probiotics Prevent Hypertension in a Murine Model of Systemic Lupus Erythematosus Induced by Toll-Like Receptor 7 Activation</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>de la Visitación, Néstor ; Robles-Vera, Iñaki ; Moleón-Moya, Javier ; Sánchez, Manuel ; Jiménez, Rosario ; Gómez-Guzmán, Manuel ; González-Correa, Cristina ; Olivares, Mónica ; Toral, Marta ; Romero, Miguel ; Duarte, Juan</creator><creatorcontrib>de la Visitación, Néstor ; Robles-Vera, Iñaki ; Moleón-Moya, Javier ; Sánchez, Manuel ; Jiménez, Rosario ; Gómez-Guzmán, Manuel ; González-Correa, Cristina ; Olivares, Mónica ; Toral, Marta ; Romero, Miguel ; Duarte, Juan</creatorcontrib><description>Our group tested the effects of Lactobacillus fermentum CECT5716 (LC40) and/or Bifidobacterium breve CECT7263 (BFM) in the prevention of gut dysbiosis, hypertension and endothelial dysfunction in a pharmacologically-induced model of systemic lupus erythematosus (SLE). We treated eight-week-old BALB/cByJRj mice without (Ctrl) or with the agonist of TLR-7 Imiquimod (IMQ) for 8 weeks. Concomitantly, LC40 (109 CFU/mL) and BFM (109 CFU/mL) were administered through oral gavage once a day. IMQ induced intestinal dysbiosis consisting of a decrease in the α-diversity measured with Chao-richness and numbers of species. LC40 and BFM did not restore these parameters. The three-dimensional principal component analysis of bacterial taxa in stool samples presented perfect clustering between Ctrl and IMQ groups. Clusters corresponding to LC40 and BFM were more akin to IMQ. BFM and LC40 were detected colonizing the gut microbiota of mice treated respectively. LC40 and BFM decreased plasma double-stranded DNA autoantibodies, and B cells in spleen, which were increased in the IMQ group. Also, LC40 and BFM treatments activated TLR9, reduced T cells activation, and Th17 polarization in mesenteric lymph nodes. Aortae from IMQ mice displayed a decreased endothelium-dependent vasodilator response to acetylcholine linked to pro-inflammatory and pro-oxidative status, which were normalized by both BFM and LC40. In conclusion, we demonstrate for the first time that the chronic treatment with LC40 or BFM prevented hypertension and endothelial dysfunction in a mouse lupus model induced by TLR-7 activation.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu13082669</identifier><identifier>PMID: 34444829</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Acetylcholine ; Analysis ; Animal models ; Autoantibodies ; Autoimmunity ; B cells ; Blood pressure ; Blood vessels ; Cardiovascular disease ; Cell activation ; Chronic conditions ; Clustering ; Coronary vessels ; Deoxyribonucleic acid ; Digestive system ; Dilatation ; DNA ; Dysbacteriosis ; Endothelium ; Enzymes ; Helper cells ; Hypertension ; Imiquimod ; Inflammation ; Intestinal microflora ; Kidneys ; Laboratory animals ; Lupus ; Lymph nodes ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Microbiota ; Microbiota (Symbiotic organisms) ; Pathogens ; Physiology ; Plasma ; Principal components analysis ; Probiotics ; Spleen ; Systemic lupus erythematosus ; T cells ; Three dimensional analysis ; TLR9 protein ; Toll-like receptors</subject><ispartof>Nutrients, 2021-07, Vol.13 (8), p.2669</ispartof><rights>COPYRIGHT 2021 MDPI AG</rights><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-71da2c235f14a8d7cc0e1a71108caa63c0ad96f09b23f57e79ea89d8bdad1e543</citedby><cites>FETCH-LOGICAL-c450t-71da2c235f14a8d7cc0e1a71108caa63c0ad96f09b23f57e79ea89d8bdad1e543</cites><orcidid>0000-0003-0578-1099 ; 0000-0001-5324-8569 ; 0000-0001-7229-9601 ; 0000-0003-2452-9286 ; 0000-0002-0828-6598 ; 0000-0002-9153-5857</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399640/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399640/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>de la Visitación, Néstor</creatorcontrib><creatorcontrib>Robles-Vera, Iñaki</creatorcontrib><creatorcontrib>Moleón-Moya, Javier</creatorcontrib><creatorcontrib>Sánchez, Manuel</creatorcontrib><creatorcontrib>Jiménez, Rosario</creatorcontrib><creatorcontrib>Gómez-Guzmán, Manuel</creatorcontrib><creatorcontrib>González-Correa, Cristina</creatorcontrib><creatorcontrib>Olivares, Mónica</creatorcontrib><creatorcontrib>Toral, Marta</creatorcontrib><creatorcontrib>Romero, Miguel</creatorcontrib><creatorcontrib>Duarte, Juan</creatorcontrib><title>Probiotics Prevent Hypertension in a Murine Model of Systemic Lupus Erythematosus Induced by Toll-Like Receptor 7 Activation</title><title>Nutrients</title><description>Our group tested the effects of Lactobacillus fermentum CECT5716 (LC40) and/or Bifidobacterium breve CECT7263 (BFM) in the prevention of gut dysbiosis, hypertension and endothelial dysfunction in a pharmacologically-induced model of systemic lupus erythematosus (SLE). We treated eight-week-old BALB/cByJRj mice without (Ctrl) or with the agonist of TLR-7 Imiquimod (IMQ) for 8 weeks. Concomitantly, LC40 (109 CFU/mL) and BFM (109 CFU/mL) were administered through oral gavage once a day. IMQ induced intestinal dysbiosis consisting of a decrease in the α-diversity measured with Chao-richness and numbers of species. LC40 and BFM did not restore these parameters. The three-dimensional principal component analysis of bacterial taxa in stool samples presented perfect clustering between Ctrl and IMQ groups. Clusters corresponding to LC40 and BFM were more akin to IMQ. BFM and LC40 were detected colonizing the gut microbiota of mice treated respectively. LC40 and BFM decreased plasma double-stranded DNA autoantibodies, and B cells in spleen, which were increased in the IMQ group. Also, LC40 and BFM treatments activated TLR9, reduced T cells activation, and Th17 polarization in mesenteric lymph nodes. Aortae from IMQ mice displayed a decreased endothelium-dependent vasodilator response to acetylcholine linked to pro-inflammatory and pro-oxidative status, which were normalized by both BFM and LC40. In conclusion, we demonstrate for the first time that the chronic treatment with LC40 or BFM prevented hypertension and endothelial dysfunction in a mouse lupus model induced by TLR-7 activation.</description><subject>Acetylcholine</subject><subject>Analysis</subject><subject>Animal models</subject><subject>Autoantibodies</subject><subject>Autoimmunity</subject><subject>B cells</subject><subject>Blood pressure</subject><subject>Blood vessels</subject><subject>Cardiovascular disease</subject><subject>Cell activation</subject><subject>Chronic conditions</subject><subject>Clustering</subject><subject>Coronary vessels</subject><subject>Deoxyribonucleic acid</subject><subject>Digestive system</subject><subject>Dilatation</subject><subject>DNA</subject><subject>Dysbacteriosis</subject><subject>Endothelium</subject><subject>Enzymes</subject><subject>Helper cells</subject><subject>Hypertension</subject><subject>Imiquimod</subject><subject>Inflammation</subject><subject>Intestinal microflora</subject><subject>Kidneys</subject><subject>Laboratory animals</subject><subject>Lupus</subject><subject>Lymph nodes</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Pathogens</subject><subject>Physiology</subject><subject>Plasma</subject><subject>Principal components analysis</subject><subject>Probiotics</subject><subject>Spleen</subject><subject>Systemic lupus erythematosus</subject><subject>T cells</subject><subject>Three dimensional analysis</subject><subject>TLR9 protein</subject><subject>Toll-like receptors</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkl9L3jAUxsvYUHHe-AkCuxmDuvxpk_Zm8CI6hVeUzV2HNDnVuDbpkvSFwj78UpRNZScXOUl-5wnP4RTFMcEnjLX4s5sJww3lvH1THFAsaMl5xd4-y_eLoxgf8BoCC872in1W5Whoe1D8vgm-sz5ZHdFNgB24hC6WCUICF613yDqk0NUcrAN05Q0MyPfo-xITjFaj7TzNEZ2FJd3DqJKP-XTpzKzBoG5Bt34Yyq39CegbaJiSD0igjU52p1IWf1-869UQ4ehpPyx-nJ_dnl6U2-uvl6ebbamrGqdSEKOopqzuSaUaI7TGQJQgBDdaKc40VqblPW47yvpagGhBNa1pOqMMgbpih8WXR91p7kYwOpsMapBTsKMKi_TKypcvzt7LO7-TDWtbXuEs8PFJIPhfM8QkRxs1DINy4Ocoac05ZpQQkdEPr9AHPweX7a1UnbtOxTPqTg0gret9_levonIjeM2zb8YzdfIfKi-zNt876G2-f1Hw6bFABx9jgP6vR4LlOi7y37iwP-qRsTg</recordid><startdate>20210731</startdate><enddate>20210731</enddate><creator>de la Visitación, Néstor</creator><creator>Robles-Vera, Iñaki</creator><creator>Moleón-Moya, Javier</creator><creator>Sánchez, Manuel</creator><creator>Jiménez, Rosario</creator><creator>Gómez-Guzmán, Manuel</creator><creator>González-Correa, Cristina</creator><creator>Olivares, Mónica</creator><creator>Toral, Marta</creator><creator>Romero, Miguel</creator><creator>Duarte, Juan</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0578-1099</orcidid><orcidid>https://orcid.org/0000-0001-5324-8569</orcidid><orcidid>https://orcid.org/0000-0001-7229-9601</orcidid><orcidid>https://orcid.org/0000-0003-2452-9286</orcidid><orcidid>https://orcid.org/0000-0002-0828-6598</orcidid><orcidid>https://orcid.org/0000-0002-9153-5857</orcidid></search><sort><creationdate>20210731</creationdate><title>Probiotics Prevent Hypertension in a Murine Model of Systemic Lupus Erythematosus Induced by Toll-Like Receptor 7 Activation</title><author>de la Visitación, Néstor ; Robles-Vera, Iñaki ; Moleón-Moya, Javier ; Sánchez, Manuel ; Jiménez, Rosario ; Gómez-Guzmán, Manuel ; González-Correa, Cristina ; Olivares, Mónica ; Toral, Marta ; Romero, Miguel ; Duarte, Juan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-71da2c235f14a8d7cc0e1a71108caa63c0ad96f09b23f57e79ea89d8bdad1e543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetylcholine</topic><topic>Analysis</topic><topic>Animal models</topic><topic>Autoantibodies</topic><topic>Autoimmunity</topic><topic>B cells</topic><topic>Blood pressure</topic><topic>Blood vessels</topic><topic>Cardiovascular disease</topic><topic>Cell activation</topic><topic>Chronic conditions</topic><topic>Clustering</topic><topic>Coronary vessels</topic><topic>Deoxyribonucleic acid</topic><topic>Digestive system</topic><topic>Dilatation</topic><topic>DNA</topic><topic>Dysbacteriosis</topic><topic>Endothelium</topic><topic>Enzymes</topic><topic>Helper cells</topic><topic>Hypertension</topic><topic>Imiquimod</topic><topic>Inflammation</topic><topic>Intestinal microflora</topic><topic>Kidneys</topic><topic>Laboratory animals</topic><topic>Lupus</topic><topic>Lymph nodes</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Pathogens</topic><topic>Physiology</topic><topic>Plasma</topic><topic>Principal components analysis</topic><topic>Probiotics</topic><topic>Spleen</topic><topic>Systemic lupus erythematosus</topic><topic>T cells</topic><topic>Three dimensional analysis</topic><topic>TLR9 protein</topic><topic>Toll-like receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de la Visitación, Néstor</creatorcontrib><creatorcontrib>Robles-Vera, Iñaki</creatorcontrib><creatorcontrib>Moleón-Moya, Javier</creatorcontrib><creatorcontrib>Sánchez, Manuel</creatorcontrib><creatorcontrib>Jiménez, Rosario</creatorcontrib><creatorcontrib>Gómez-Guzmán, Manuel</creatorcontrib><creatorcontrib>González-Correa, Cristina</creatorcontrib><creatorcontrib>Olivares, Mónica</creatorcontrib><creatorcontrib>Toral, Marta</creatorcontrib><creatorcontrib>Romero, Miguel</creatorcontrib><creatorcontrib>Duarte, Juan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de la Visitación, Néstor</au><au>Robles-Vera, Iñaki</au><au>Moleón-Moya, Javier</au><au>Sánchez, Manuel</au><au>Jiménez, Rosario</au><au>Gómez-Guzmán, Manuel</au><au>González-Correa, Cristina</au><au>Olivares, Mónica</au><au>Toral, Marta</au><au>Romero, Miguel</au><au>Duarte, Juan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Probiotics Prevent Hypertension in a Murine Model of Systemic Lupus Erythematosus Induced by Toll-Like Receptor 7 Activation</atitle><jtitle>Nutrients</jtitle><date>2021-07-31</date><risdate>2021</risdate><volume>13</volume><issue>8</issue><spage>2669</spage><pages>2669-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Our group tested the effects of Lactobacillus fermentum CECT5716 (LC40) and/or Bifidobacterium breve CECT7263 (BFM) in the prevention of gut dysbiosis, hypertension and endothelial dysfunction in a pharmacologically-induced model of systemic lupus erythematosus (SLE). We treated eight-week-old BALB/cByJRj mice without (Ctrl) or with the agonist of TLR-7 Imiquimod (IMQ) for 8 weeks. Concomitantly, LC40 (109 CFU/mL) and BFM (109 CFU/mL) were administered through oral gavage once a day. IMQ induced intestinal dysbiosis consisting of a decrease in the α-diversity measured with Chao-richness and numbers of species. LC40 and BFM did not restore these parameters. The three-dimensional principal component analysis of bacterial taxa in stool samples presented perfect clustering between Ctrl and IMQ groups. Clusters corresponding to LC40 and BFM were more akin to IMQ. BFM and LC40 were detected colonizing the gut microbiota of mice treated respectively. LC40 and BFM decreased plasma double-stranded DNA autoantibodies, and B cells in spleen, which were increased in the IMQ group. Also, LC40 and BFM treatments activated TLR9, reduced T cells activation, and Th17 polarization in mesenteric lymph nodes. Aortae from IMQ mice displayed a decreased endothelium-dependent vasodilator response to acetylcholine linked to pro-inflammatory and pro-oxidative status, which were normalized by both BFM and LC40. In conclusion, we demonstrate for the first time that the chronic treatment with LC40 or BFM prevented hypertension and endothelial dysfunction in a mouse lupus model induced by TLR-7 activation.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34444829</pmid><doi>10.3390/nu13082669</doi><orcidid>https://orcid.org/0000-0003-0578-1099</orcidid><orcidid>https://orcid.org/0000-0001-5324-8569</orcidid><orcidid>https://orcid.org/0000-0001-7229-9601</orcidid><orcidid>https://orcid.org/0000-0003-2452-9286</orcidid><orcidid>https://orcid.org/0000-0002-0828-6598</orcidid><orcidid>https://orcid.org/0000-0002-9153-5857</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6643 |
| ispartof | Nutrients, 2021-07, Vol.13 (8), p.2669 |
| issn | 2072-6643 2072-6643 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8399640 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Acetylcholine Analysis Animal models Autoantibodies Autoimmunity B cells Blood pressure Blood vessels Cardiovascular disease Cell activation Chronic conditions Clustering Coronary vessels Deoxyribonucleic acid Digestive system Dilatation DNA Dysbacteriosis Endothelium Enzymes Helper cells Hypertension Imiquimod Inflammation Intestinal microflora Kidneys Laboratory animals Lupus Lymph nodes Lymphocytes Lymphocytes B Lymphocytes T Microbiota Microbiota (Symbiotic organisms) Pathogens Physiology Plasma Principal components analysis Probiotics Spleen Systemic lupus erythematosus T cells Three dimensional analysis TLR9 protein Toll-like receptors |
| title | Probiotics Prevent Hypertension in a Murine Model of Systemic Lupus Erythematosus Induced by Toll-Like Receptor 7 Activation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T21%3A14%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Probiotics%20Prevent%20Hypertension%20in%20a%20Murine%20Model%20of%20Systemic%20Lupus%20Erythematosus%20Induced%20by%20Toll-Like%20Receptor%207%20Activation&rft.jtitle=Nutrients&rft.au=de%20la%20Visitaci%C3%B3n,%20N%C3%A9stor&rft.date=2021-07-31&rft.volume=13&rft.issue=8&rft.spage=2669&rft.pages=2669-&rft.issn=2072-6643&rft.eissn=2072-6643&rft_id=info:doi/10.3390/nu13082669&rft_dat=%3Cgale_pubme%3EA765645036%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2565482277&rft_id=info:pmid/34444829&rft_galeid=A765645036&rfr_iscdi=true |