miRNA-146a and miRNA-126 as Potential Biomarkers in Patients with Coronary Artery Disease and Generalized Periodontitis
The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. A total of 75 participants were selected and grouped into three catego...
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| Veröffentlicht in: | Materials 2021-08, Vol.14 (16), p.4692 |
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| creator | Mahendra, Jaideep Mahendra, Little Fageeh, Hytham N. Fageeh, Hammam Ibrahim Ibraheem, Wael Abdulkarim, Hesham H. Kanakamedala, Anilkumar Prakash, Prashanthi Srinivasan, Sruthi Balaji, Thodur Madapusi Varadarajan, Saranya Jagannathan, Raghunathan Patil, Shankargouda |
| description | The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. A total of 75 participants were selected and grouped into three categories of 25 patients each: GP+CAD, GP, and HP groups. GP+CAD consisted of patients diagnosed with generalized periodontitis (GP) and coronary artery disease (CAD). The GP+CAD group was further divided into two groups—GP+CADa: where subgingival plaque samples were collected; GP+CADb group: where coronary plaque samples were collected while the patient underwent a coronary artery bypass grafting surgery. The GP group consisted of 25 patients diagnosed with only generalized periodontitis. The HP group consisted of 25 systemically and periodontally healthy controls. miRNA-146a and miRNA126 levels were assessed in subgingival plaque (SP) samples from all groups. Results revealed that miRNA-146a was expressed at higher levels and miRNA-126 was downregulated in the GP+CAD group. microRNAs in subgingival plaque samples showed a significant correlation with the coronary plaque samples in the GP+CAD group. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis. These micro-RNAs may serve as risk biomarkers for coronary artery disease and generalized periodontitis. |
| doi_str_mv | 10.3390/ma14164692 |
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A total of 75 participants were selected and grouped into three categories of 25 patients each: GP+CAD, GP, and HP groups. GP+CAD consisted of patients diagnosed with generalized periodontitis (GP) and coronary artery disease (CAD). The GP+CAD group was further divided into two groups—GP+CADa: where subgingival plaque samples were collected; GP+CADb group: where coronary plaque samples were collected while the patient underwent a coronary artery bypass grafting surgery. The GP group consisted of 25 patients diagnosed with only generalized periodontitis. The HP group consisted of 25 systemically and periodontally healthy controls. miRNA-146a and miRNA126 levels were assessed in subgingival plaque (SP) samples from all groups. Results revealed that miRNA-146a was expressed at higher levels and miRNA-126 was downregulated in the GP+CAD group. microRNAs in subgingival plaque samples showed a significant correlation with the coronary plaque samples in the GP+CAD group. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis. These micro-RNAs may serve as risk biomarkers for coronary artery disease and generalized periodontitis.</description><identifier>ISSN: 1996-1944</identifier><identifier>EISSN: 1996-1944</identifier><identifier>DOI: 10.3390/ma14164692</identifier><identifier>PMID: 34443215</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Apoptosis ; Biomarkers ; Blood pressure ; Body mass index ; Cardiovascular disease ; Cholesterol ; Coronary artery disease ; Coronary vessels ; Cytokines ; Gene expression ; Heart surgery ; Inflammation ; Kinases ; Lipoproteins ; MicroRNAs ; Patients ; Periodontium ; Tumor necrosis factor-TNF</subject><ispartof>Materials, 2021-08, Vol.14 (16), p.4692</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-9ff0c24c0cf5f1fb4d0b79c009156765ad4b611872ec148c715962bf0d0326e33</citedby><cites>FETCH-LOGICAL-c383t-9ff0c24c0cf5f1fb4d0b79c009156765ad4b611872ec148c715962bf0d0326e33</cites><orcidid>0000-0001-7246-5497 ; 0000-0001-8472-517X ; 0000-0001-9061-6367 ; 0000-0002-7051-1143 ; 0000-0002-8208-4855</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398247/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398247/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids></links><search><creatorcontrib>Mahendra, Jaideep</creatorcontrib><creatorcontrib>Mahendra, Little</creatorcontrib><creatorcontrib>Fageeh, Hytham N.</creatorcontrib><creatorcontrib>Fageeh, Hammam Ibrahim</creatorcontrib><creatorcontrib>Ibraheem, Wael</creatorcontrib><creatorcontrib>Abdulkarim, Hesham H.</creatorcontrib><creatorcontrib>Kanakamedala, Anilkumar</creatorcontrib><creatorcontrib>Prakash, Prashanthi</creatorcontrib><creatorcontrib>Srinivasan, Sruthi</creatorcontrib><creatorcontrib>Balaji, Thodur Madapusi</creatorcontrib><creatorcontrib>Varadarajan, Saranya</creatorcontrib><creatorcontrib>Jagannathan, Raghunathan</creatorcontrib><creatorcontrib>Patil, Shankargouda</creatorcontrib><title>miRNA-146a and miRNA-126 as Potential Biomarkers in Patients with Coronary Artery Disease and Generalized Periodontitis</title><title>Materials</title><description>The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. 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Results revealed that miRNA-146a was expressed at higher levels and miRNA-126 was downregulated in the GP+CAD group. microRNAs in subgingival plaque samples showed a significant correlation with the coronary plaque samples in the GP+CAD group. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis. 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A total of 75 participants were selected and grouped into three categories of 25 patients each: GP+CAD, GP, and HP groups. GP+CAD consisted of patients diagnosed with generalized periodontitis (GP) and coronary artery disease (CAD). The GP+CAD group was further divided into two groups—GP+CADa: where subgingival plaque samples were collected; GP+CADb group: where coronary plaque samples were collected while the patient underwent a coronary artery bypass grafting surgery. The GP group consisted of 25 patients diagnosed with only generalized periodontitis. The HP group consisted of 25 systemically and periodontally healthy controls. miRNA-146a and miRNA126 levels were assessed in subgingival plaque (SP) samples from all groups. Results revealed that miRNA-146a was expressed at higher levels and miRNA-126 was downregulated in the GP+CAD group. microRNAs in subgingival plaque samples showed a significant correlation with the coronary plaque samples in the GP+CAD group. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis. These micro-RNAs may serve as risk biomarkers for coronary artery disease and generalized periodontitis.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34443215</pmid><doi>10.3390/ma14164692</doi><orcidid>https://orcid.org/0000-0001-7246-5497</orcidid><orcidid>https://orcid.org/0000-0001-8472-517X</orcidid><orcidid>https://orcid.org/0000-0001-9061-6367</orcidid><orcidid>https://orcid.org/0000-0002-7051-1143</orcidid><orcidid>https://orcid.org/0000-0002-8208-4855</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Apoptosis Biomarkers Blood pressure Body mass index Cardiovascular disease Cholesterol Coronary artery disease Coronary vessels Cytokines Gene expression Heart surgery Inflammation Kinases Lipoproteins MicroRNAs Patients Periodontium Tumor necrosis factor-TNF |
| title | miRNA-146a and miRNA-126 as Potential Biomarkers in Patients with Coronary Artery Disease and Generalized Periodontitis |
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