Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats

Physiologically based pharmacokinetic (PBPK) models are increasingly used in drug development to simulate changes in both systemic and tissue exposures that arise as a result of changes in enzyme and/or transporter activity. Verification of these model-based simulations of tissue exposure is challen...

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Veröffentlicht in:	Molecular pharmaceutics 2021-08, Vol.18 (8), p.2997-3009
Hauptverfasser:	Scotcher, Daniel, Melillo, Nicola, Tadimalla, Sirisha, Darwich, Adam S, Ziemian, Sabina, Ogungbenro, Kayode, Schütz, Gunnar, Sourbron, Steven, Galetin, Aleksandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport, Active - drug effects Biomarkers - metabolism Cells, Cultured Contrast Media - administration & dosage Contrast Media - metabolism Contrast Media - pharmacokinetics Drug Interactions Gadolinium DTPA - administration & dosage Gadolinium DTPA - metabolism Gadolinium DTPA - pharmacokinetics Hepatocytes - drug effects Hepatocytes - metabolism Liver - diagnostic imaging Liver - metabolism Magnetic Resonance Imaging - methods Male Models, Animal Organic Anion Transporters - antagonists & inhibitors Organic Anion Transporters - metabolism Rats Rifampin - administration & dosage Rifampin - metabolism Rifampin - pharmacokinetics
Online-Zugang:	Volltext
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