Common Kinetic Mechanism of Abasic Site Recognition by Structurally Different Apurinic/Apyrimidinic Endonucleases

Apurinic/apyrimidinic (AP) endonucleases Nfo ( ) and APE1 (human) represent two conserved structural families of enzymes that cleave AP-site-containing DNA in base excision repair. Nfo and APE1 have completely different structures of the DNA-binding site, catalytically active amino acid residues and...

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Veröffentlicht in:	International journal of molecular sciences 2021-08, Vol.22 (16), p.8874
Hauptverfasser:	Kuznetsova, Alexandra A, Senchurova, Svetlana I, Ishchenko, Alexander A, Saparbaev, Murat, Fedorova, Olga S, Kuznetsov, Nikita A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Base excision repair Binding Sites Biochemistry, Molecular Biology Catalysis Catalytic Domain Complex formation Deoxyribonucleic acid DNA DNA Cleavage DNA Damage DNA Repair DNA-(Apurinic or Apyrimidinic Site) Lyase - chemistry DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism Enzymes Escherichia coli Extrusion Flexibility Fluorescence Humans Kinetics Life Sciences Metal ions Molecular Dynamics Simulation Nucleic Acid Conformation Nucleotides Nucleotides - chemistry Nucleotides - metabolism Protein Conformation Proteins Recognition Stability analysis Structural Biology Substrate Specificity
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