Structural Basis of Inhibition of DCLK1 by Ruxolitinib

Given the functional attributes of Doublecortin-like kinase 1 (DCLK1) in tumor growth, invasion, metastasis, cell motility, and tumor stemness, it is emerging as a therapeutic target in gastrointestinal cancers. Although a series of specific or nonspecific ATP-competitive inhibitors were identified...

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Veröffentlicht in:	International journal of molecular sciences 2021-08, Vol.22 (16), p.8488, Article 8488
Hauptverfasser:	Jang, Dong Man, Lim, Hyo Jin, Hahn, Hyunggu, Lee, Yeon, Kim, Hark Kyun, Kim, Hyoun Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	anticancer ATP-competitive inhibitor Binding Binding sites Biochemistry & Molecular Biology Cancer Chemistry Chemistry, Multidisciplinary Crystal structure DCLK1 Doublecortin protein doublecortin-like kinase 1 Enzyme inhibitors Hydrogen bonds Janus kinase kinase inhibitor Kinases Libraries Life Sciences & Biomedicine Metastases Mutation Optimization Phosphorylation Physical Sciences Science & Technology structure-based drug discovery Targeted cancer therapy Therapeutic targets Tumors
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