Antagonists of Growth Hormone-Releasing Hormone Inhibit the Growth of Pituitary Adenoma Cells by Hampering Oncogenic Pathways and Promoting Apoptotic Signaling

Pituitary adenomas (PAs) are intracranial tumors, often associated with excessive hormonal secretion and severe comorbidities. Some patients are resistant to medical therapies; therefore, novel treatment options are needed. Antagonists of growth hormone-releasing hormone (GHRH) exert potent anticanc...

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Veröffentlicht in:	Cancers 2021-08, Vol.13 (16), p.3950
Hauptverfasser:	Gesmundo, Iacopo, Granato, Giuseppina, Fuentes-Fayos, Antonio C., Alvarez, Clara V., Dieguez, Carlos, Zatelli, Maria Chiara, Congiusta, Noemi, Banfi, Dana, Prencipe, Nunzia, Leone, Sheila, Brunetti, Luigi, Castaño, Justo P., Luque, Raúl M., Cai, Renzhi, Sha, Wei, Ghigo, Ezio, Schally, Andrew V., Granata, Riccarda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma Adrenocorticotropic hormone Antagonists Apoptosis Brain cancer Brain tumors Cell culture Cell death Cell viability Diabetic retinopathy Dopamine Drug therapy Growth hormone-releasing hormone Growth hormones Pituitary Polyclonal antibodies Prolactin Reagents Secretion Surgery Temozolomide Tumor cells Tumorigenesis Tumors
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