Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment

Current systemic treatment options for patients with adrenocortical carcinomas (ACCs) are far from being satisfactory. DNA damage/repair mechanisms, which involve, e.g., ataxia-telangiectasia-mutated (ATM) and ataxia-telangiectasia/Rad3-related (ATR) protein signaling or ribonucleotide reductase sub...

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Veröffentlicht in:	Cancers 2021-08, Vol.13 (16), p.4200
Hauptverfasser:	Bothou, Christina, Sharma, Ashish, Oo, Adrian, Kim, Baek, Perge, Pal, Igaz, Peter, Ronchi, Cristina L, Shapiro, Igor, Hantel, Constanze
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Carcinoma CHK1 protein Cisplatin Deoxyribonucleic acid DNA DNA damage DNA repair Doxorubicin Drug resistance Drug screening Enzymes Etoposide Experiments Gemcitabine Growth factors Insulin-like growth factors Kinases Metastasis p53 Protein Patients Reductase Ribonucleotide reductase Tumors Wnt protein
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