Nitric Oxide Synthase Dependency in Hydroxyurea Inhibition of Erythroid Progenitor Growth

Hydroxyurea (HU) causes nitric oxide (NO) bioactivation, acting as both a NO donor and a stimulator of NO synthase (NOS). To examine whether HU effects are NO mediated by chemical degradation or enzymatic induction, we studied human and mouse erythroid cells during proliferation, apoptosis, and diff...

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Veröffentlicht in:	Genes 2021-07, Vol.12 (8), p.1145
Hauptverfasser:	Subotički, Tijana, Ajtić, Olivera Mitrović, Đikić, Dragoslava, Santibanez, Juan F, Tošić, Milica, Čokić, Vladan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Apoptosis Arginine Bone marrow Cell culture Cell cycle Cell differentiation Cell proliferation Cell Proliferation - drug effects Chemical degradation Colonies Enzymes Erythroid cells Erythroid Precursor Cells - cytology Erythroid Precursor Cells - drug effects Gene expression Hemoglobin Humans Humidity Hydroxyurea Hydroxyurea - pharmacology Immunoglobulins Inhalation K562 Cells Mice NG-Nitroarginine methyl ester Nitric oxide Nitric Oxide Donors - pharmacology Nitric Oxide Synthase - metabolism Nitric-oxide synthase Penicillin Proteins Ribonucleotide reductase Sodium
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